Conserved Protein Domain Family
RING-HC_RNF20

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cd16814: RING-HC_RNF20 
RING finger, HC subclass, found in RING finger protein 20 (RNF20)
RNF20, also known as BRE1A or BRE1, is an E3 ubiquitin-protein ligase that forms a heterodimeric complex together with BRE1B, also known as RNF40, to facilitate the K120 monoubiquitination of histone H2B (H2Bub1), a DNA damage-induced histone modification that is crucial for recruitment of the chromatin remodeler SNF2h to DNA double-strand break (DSB) damage sites. It regulates the cell cycle and differentiation of neural precursor cells (NPCs), and links histone H2B ubiquitylation with inflammation and inflammation-associated cancer. Moreover, RNF20 promotes the polyubiquitination and proteasome-dependent degradation of transcription factor activator protein 2alpha (AP-2alpha), a negative regulator of adipogenesis by repressing the transcription of CCAAT/enhancer binding protein (C/EBPalpha) gene. Furthermore, RNF20 functions as an additional chromatin regulator that is necessary for mixed-lineage leukemia (MLL)-fusion-mediated leukemogenesis. It also inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. TFIIS is a factor capable of relieving stalled RNA polymerase II. RNF20 contains a C3HC4-type RING-HC finger at its C-terminus.
Statistics
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PSSM-Id: 319728
View PSSM: cd16814
Aligned: 6 rows
Threshold Bit Score: 92.0906
Threshold Setting Gi: 229297470
Created: 23-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Saccharomyces cerevisiae Bre1 (4R7E) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
Feature 1           #  #           # #  #  #           #  #     
gi 84027766   920 LTCPCCNMRkKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFG 965
gi 371874078  958 LTCPCCNSRvKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFG 1003
gi 82197874   929 LTCPCCNMRkKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFG 974
gi 163914497  910 LTCPCCNSRkMDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFG 955
gi 229297470  189 LTCPCCNTRkKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFG 234
gi 557024246  949 LTCPCCNMRkKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFG 994

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