Conserved Protein Domain Family
RING_CH-C4HC3_MARCH4

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cd16824: RING_CH-C4HC3_MARCH4 
RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH4 (MARCH4)
MARCH4, also known as membrane-associated RING finger protein 4, membrane-associated RING-CH protein IV (MARCH-IV), or RING finger protein 174 (RNF174), is a transmembrane E3 ubiquitin-protein ligase that down-regulates the tetraspanin CD81 and major histocompatibility complex-I (MHC). It also associates with Mult1, suppressing Mult1 expression at the cell surface in a lysine-dependent manner that can be reversed by heat shocking the cells. MARCH4 contains an N-terminal C4HC3-type RING-CH finger, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger, followed by two transmembrane regions.
Statistics
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PSSM-Id: 319738
View PSSM: cd16824
Aligned: 4 rows
Threshold Bit Score: 109.372
Threshold Setting Gi: 512865387
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-CH finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens MARCH8 (2D8S) binds two Zn2+ ions through its RING-CH finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1         #  #            # #       #  #            #  #    
gi 59798475  162 LCRICFQGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGcWSCELCYYKY 212
gi 123914442 142 LCRICFQGPEQGELLSPCRCSGSVRCTHEPCLIKWISERGsWSCELCYYKY 192
gi 591349931 220 LCRICFQGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGcWSCELCYYKY 270
gi 512865387 139 LCRICFQGPEQGELLSPCRCDGSVRCSHQPCLIKWISERGsWSCELCYYKY 189

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