1HQ0,1HZG,2F9Z,1XFJ


Conserved Protein Domain Family
CNF1_CheD_YfiH-like

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cd16832: CNF1_CheD_YfiH-like 
Click on image for an interactive view with Cn3D
cytotoxic necrotizing factor 1 (CNF1), chemotaxis protein CheD and YfiH (DUF152) are distant homologs
This family contains distant homologs that include cytotoxic necrotizing factor 1 (CNF1), chemotaxis protein CheD and a protein of unknown function YfiH. CNF-1 along with dermonecrotic toxin (DNT) from Bordetella species, and Burkholderia Lethal Factor 1 (BLF1, also known as BPSL1549) are Rho-activating toxins. The bacterial chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). YfiH, a domain of unknown function, also included in this family reveals a structure with a distant homology between to the CNF1, and CheD, all having an invariant Cys-His pair forming a catalytic dyad that is required by the CNF-1 toxins for deamidation activity.
Statistics
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PSSM-Id: 319353
View PSSM: cd16832
Aligned: 4 rows
Threshold Bit Score: 146.773
Threshold Setting Gi: 55670843
Created: 22-Dec-2011
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: putative catalytic site [active site], 2 residue positions
Conserved feature residue pattern:[CS] HClick to see conserved feature residue pattern help
Evidence:
  • Comment:His and Cys/Ser form a catalytic triad together with a backbone carbonyl or suitable side-chain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                      10        20        30        40        50        60        70        80
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        #                #           
1HQ0_A    111 IIRVSNsar---------------gaNGIKIaleevqegkPVIITSGnlSGCTTIVARKeg--yIYKVHTGttkslag-f 172
1HZG_A    111 IIRVSNsar---------------gaNGIKIaleevqegkPVIITSGnlSGSTTIVARKeg--yIYKVHTGttkslag-f 172
2F9Z_D      4 KKVIGIg-------------------EYAVMk-------nPGVIVTLglGSCVAVCMRDpvakvGAMAHVMlpdsggktd 57
1XFJ_A     70 LNVCYQihstiaivadgswgdarpegDAVVSkt------pGVICGAXa-ADCAPVLLVDpeariVAAAHAGwrg------ 136
                      90       100       110       120       130       140       150       160
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     
1HQ0_A    173 tsttgvKKAVEVLELltkepiprvegimsndflvdylsenFEDSLITYsssekkpds----------------------- 229
1HZG_A    173 tsttgvKKAVEVLELltkepiprvegimsndflvdylsenFEDSLITYsssekkpds----------------------- 229
2F9Z_D     58 kpgkyaDTAVKTLVEelkkm---------------gakveRLEAKIAGgasmfeskgmnigarn---------------- 106
1XFJ_A    137 ----alDGVVQSAVDrxvel---------------gaspaNITGVVGPcigpksyevgleflhrfeadcpgsgrffkpga 197
                     170       180       190       200       210       220
              ....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                                   
1HQ0_A    230 ----------------qitiirdnVSVFPYfldni---------------pehgFGTSATVL 260
1HZG_A    230 ----------------qitiirdnVSVFPYfldni---------------pehgFGTSATVL 260
2F9Z_D    107 ---------veavkkhlkdfgiklLAEDTGgn---------------------rARSVEYNI 138
1XFJ_A    198 sedkrffdlpafvldrlatagverREWVGRdtraeeewffsnrraflnndgdygRLLSAITL 259

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