1XFJ,1T8H,1RV9,1Z9T,1RW0,1U05,1XAF


Conserved Protein Domain Family
YfiH

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cd16833: YfiH 
Click on image for an interactive view with Cn3D
protein of unknown function YfiH
This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.
Statistics
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PSSM-Id: 319354
View PSSM: cd16833
Aligned: 966 rows
Threshold Bit Score: 81.0916
Threshold Setting Gi: 254589797
Created: 28-Feb-2012
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: putative catalytic site [active site], 2 residue positions
Conserved feature residue pattern:[CS] HClick to see conserved feature residue pattern help
Evidence:
  • Comment:by similarity to other members of this family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           #                #            
1XFJ_A         69 DLNVCYQIHs---TIAIVadgswg-darpegDAVVSktpGVICGAXa-ADCAPVLLVDpearIVAAAHAGWRGalDGVVQ 143
gi 1025708303  42 EPVFVRQVHs---ARVLNvdkpfkrenipeaDAMVTt-hRALMLGIvtADCAPILFEDveagVIGAAHAGWRGaqAGIAH 117
gi 292665337   79 RLYGLRQCHs--aKAVLValdqda-gqrpdaDAHVTt-iAEYGLAIltADCTPVLFADreagVIGAAHAGWRGacGGVLE 154
gi 570550151   59 KVCTLQQRHtn-kVFILNsasecd--heihaDAIVTn-iLSIPIVVytADCVPIFFADvqkgVIAICHAGWRGtlNGIIE 134
gi 576110351   70 KMMFPCQVHgg-dVFIVTkdips---dapdcDGLVTd-vPGITLCVstADCAPVMFWDte-sVVGICHAGWKGvfLGVLE 143
gi 356675478   73 RMAGLYQIHs---ARCVTltdqtdcaqrpeaDAYVTa-lSGVGLAIltADCLPVLFCDarqgVIGAAHAGWRGaaAGVIE 148
gi 351593848   66 EVALVRQVHg---THVLTvdgtfdlqqrpeaDAMVTd-rSGIALGIvtADCAPILLADpkagIIGAAHAGWKGavGGILA 141
gi 612501283   47 EYVFPKQVH----SNICMftrtps-anslkcDAIVTd-qPNLTLVVktADCVPILLSDpvnhIIGVVHAGWKGlnSGVIQ 120
gi 406653589   54 NLIIPDQYHs--sKCLVAkannp----ypkcDALVTs-dNSLILGIttADCLPIIFYDpknqVIGIAHAGWKGlvKGVIQ 126
gi 406990927   29 SLVTLKQVHgikvHRITEtrkd-----apegDGLVTn-vRGIVLGIftADCGPVLFYDpeanIIGACHAGWRGakAGILQ 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1XFJ_A        144 SAVDRXvelgaspaNITGVVGPCIGPKSYEVg----lEFLHRFEAdcpgsgrffkp-----gasedkrffdlPAFVLDRL 214
gi 1025708303 118 ATVSEMeklgasrrAIRASIGPCIRQDSYEVd-----DAFREYFVfpqddeffstgrdghwqfdlagyvaaqLVSLLGGD 192
gi 292665337  155 ATINRMckagatcdNITAVIGPCIRQHSYQVg----gDLRDEALAstedaavffaadq-esgkyrfdlagyiAMRLKGCR 229
gi 570550151  135 NTVDTMkhlgsnihDIKVLIGPSIQQHSYEVq----kDFYDTFLNeskynnkffktkd-namffdlvgyaihRLRSLSIQ 209
gi 576110351  144 NTLAAVrsvsksplKVQACIGPTIRLKNYEVs----cDFYHSFIKedpescnffqkee--klffdlpgyiafRLSKKECK 217
gi 356675478  149 ATVQAMqglgadirQIVMVIGPGIRQPSYQIsaemreEIISSYPEavscfmadpaaed--kflfdlpgfakgLGQAAGLS 226
gi 351593848  142 NTIAAMerlgasraNIVAAIGPAISAENYEIgeemanEIRTQFPDaadfivtdgwpk----phfdvpglvlaQAKSLGIG 217
gi 612501283  121 NAIAKMidigsqskYINVAIGPCILRENYEVq----eDFLEAFGStgkefsrlkqgk----yyfdllgccqdILKKEGIR 192
gi 406653589  127 NTVKKMislgaqnkSIKSIIGPCIRVKSYEVn----eEFVNKLKTqyqrfairqtqk----iyfdlpklakyILSESNIS 198
gi 406990927  103 ATLREMeilgaqrsRIHASLGPTIQQKNYEVgpefpdLIRESYDTyfvpsdkkghh------yfnlplyicqQLKAEGVK 176
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           
1XFJ_A        215 atagverREWVGRDTra---eeEWFFSNRRaflnn--dgdyGRLLSAITL 259
gi 1025708303 193 s------VEITGIDTya---naEHFHSFRRathl---gkasQGRQYSLIA 230
gi 292665337  230 -------INTIHDCQrdtysesDQFFSHRFatha---gdsdSGRLISVIA 269
gi 570550151  210 c------IYDCKINTys----nFNFASFRKnkhl---dlinLGIMMLVNK 246
gi 576110351  218 -------VFDTLEDTy-----eSRFFSRRHhkkqnfcceygFGSMIGLPI 255
gi 356675478  227 q------IYDSGCDTyt---deTHFFSHRRathr---kepdSGRLISVIT 264
gi 351593848  218 t------VESVGSCTya---hpDLYFSHRYathn----ntrAGRQIALIA 254
gi 612501283  193 e------IHTSEVDTyt----nTGISSYRRtrhl---nnpdTYRNISAIV 229
gi 406653589  199 s------VHDIKKNTfl----dKNYFSFREskkk---kyrdYGRNINLIS 235
gi 406990927  177 g------IYDIGCDTf------TSYFASRRrs-------laEGYEEISID 207

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