2QTW,2PMW,4NE9,3H42


Conserved Protein Domain Family
PCSK9_C-CRD

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cd16839: PCSK9_C-CRD 
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proprotein convertase subtilisin/kexin type 9, C-terminal cysteine-rich domain (CRD)
PCSK9 post-translationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. Other known PSCK9 targets include very-low-density lipoprotein receptor (VLDLR), apoE receptor2, lipoprotein receptor-related protein 1, etc. This PCSK9 C-terminal CRD may play an analogous role to the P (processing) domains of Furin and Kex2 (i.e. be required for the correct functioning/folding of the protein). Structural similarity has been noted between PCSK9 C-terminal CRD and the resistin homotrimer. This alignment model represents a three-fold repeat.
Statistics
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PSSM-Id: 319350
View PSSM: cd16839
Aligned: 11 rows
Threshold Bit Score: 323.692
Threshold Setting Gi: 808861848
Created: 15-Mar-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2QTW_B       300 GWQLFCRTVWSAHSGptrmaTAIARCAPdeELLSCSSFSRsGKRRGERMEAQGgkLVCRAHNAFgGEGVYAIARCCLLPQ 379
gi 317373487 452 GWQLFCRTVWSAHSGptrmaTAVARCAPdeELLSCSSFSRsGKRRGERMEAQGgkLVCRAHNAFgGEGVYAIARCCLLPQ 531
2PMW_B       300 GWQLFCRTVWSAHSGptrmaTAVARCAPdeELLSCSSFSRsGKRRGERMEAQGgkLVCRAHNAFgGEGVYAIARCCLLPQ 379
4NE9_A       300 GWQLFCRTVWSAHSGptrmaTAIARCAPdeELLSCSSFSRsGKRRGERMEAQGgkLVCRAHNAFgGEGVYAIARCCLLPQ 379
3H42_B       300 GWQLFCRTVWSAHSGptrmaTAIARCAPdeELLSCSSFSRsGKRRGERMEAQGgkLVCRAHNAFgGEGVYAIARCCLLPQ 379
gi 166980547 451 GWQLFCRTVWSAHSGptrmaTAMARCAPdeELLSCSSFSRsGKRRGERIEAQGgrRVCLAPNAFgGEGVYAVARCCLLPQ 530
gi 465973961 443 GEQLYCRSVWSAPSGstrsaTAVVRCSGneEMLSCSSFSTnGKRRGERIEVHGgrKQCVAHNAFgGHGVYAIARCCIWPK 522
gi 808861848 432 DVELLCRSVWSERSGvtstdSAVSRCRQgeEMMSCSSYAPdGVHAGETVTVNDgqMECVAYNGPgGKGVFAVARCCVVGG 511
gi 55153988  442 DEELFCRTVWSKPSGfarkaTTSVQCSGneEMFSCSSFSRnGKRKGEHIEEEGgrKTCIAHNAFgGDGVYAIARCCIWPK 521
gi 944209716 406 DEQLYCRSVWSARSGltqhaTAVARCTGteEMLGCSSFSRsGRRLGEHMEDKDgqKQCMAHNAFrGQGVYAIARCCTWPR 485
gi 326676990 444 GEDLLCRSVWSERSAspvfsTAVSRCRSteEMLSCSSFSDnGMRAGERVEERDgqKECVAVNVNgGPGVFAVARCCTGHR 523
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2QTW_B       380 ANCSVHTAPPaea-smgTRVHChQQGHVLTGCSSHWevedlgthkppvlrprgqPNQCVGHREASIHASCCHAPGLECKV 458
gi 317373487 532 ANCSVHTAPPaea-smgTRVHChQQGHVLTGCSSHWevedlgthkppvlrprgqPNQCVGHREASIHASCCHAPGLECKV 610
2PMW_B       380 ANCSVHTAPPaea-smgTRVHChQQGHVLTGCSSHWevedlgthkppvlrprgqPNQCVGHREASIHASCCHAPGLECKV 458
4NE9_A       380 ANCSVHTAPPaea-smgTRVHChQQGHVLTGCSSHWevedlgthkppvlrprgqPNQCVGHREASIHASCCHAPGLECKV 458
3H42_B       380 AACSVHTAPPaea-smgTRVHChQQGHVLTGCSSHWevedlgthkppvlrprgqPNQCVGHREASIHASCCHAPGLECKV 458
gi 166980547 531 ANCSVHTAPPaga-gmgTRAHChQQGHVLTGCSSHWemkdlgthkppvlkprgqPDQCMGHSGASTHASCCYAPGLECKV 609
gi 465973961 523 ADCQIHTSSQtadgtstTGMGCsKENHVLTGCSSHSlagefsdnvrpvlkmetgHHQCVGRTDVTLHTSCCHAPSIECQV 602
gi 808861848 512 LRCQVHASPKp-----gQDAECvGLQHHLTGCTSWSteilsgs-----rphhgdRKRCVVKDGVTSDAVCCHAPSLECHV 581
gi 55153988  522 AVCHINSTTPedg-evpSTVSCsNEDHILTGCSSHHvsghlndvvrpmhrtdneDPACVGKSEVTSHALCCHAPDIACKV 600
gi 944209716 486 DKXQINASSMv-----aEGASCsPRDHVLTGCSFHSpitalgdsgrpvaglesePXXCTSRMEVTAHALCCPAASLECRV 560
gi 326676990 524 AQCQMLEGPEr-----gAGAEC-PPEHHLTGCSFSSssgeasds---drtlhgsRRTCAAKKGMMSYAFCCHTSTLECRL 594
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2QTW_B       459 KEHGIPAPQEQVTVACEeGWTLTGCSALPGTShVLGAYAVdNTCVVRSRDvsttgstseeaVTAVAICCRSRH 531
gi 317373487 611 KEHGIPAPQEQVTVACEeGWTLTGCSALPGTShVLGAYAVdNTCVVRSRDvsttgstsegaVTAVAICCRSRH 683
2PMW_B       459 KEHGIPAPQEQVTVACEeGWTLTGCSALPGTShVLGAYAVdNTCVVRSRDvsttgstsegaVTAVAICCRSRH 531
4NE9_A       459 KEHGIPAPQEQVTVACEeGWTLTGCSALPGTShVLGAYAVdNTCVVRSRDvsttgstseeaVTAVAICCRSRH 531
3H42_B       459 KEHGIPAPQGQVTVACEeGWTLTGCSALPGTShVLGAYAVdNTCVVRSRDvsttgstseeaVTAVAICCRSRH 531
gi 166980547 610 KEHGLPAPQEQVTVACEeGWTLTGCSALPGTShVLGAYAVdDTCVVRSRDvsttgstseeaVAAVAICCRSRH 682
gi 465973961 603 KEHSPVGFQEKVAVSCDeGWTLTGCNAYSWGPgTLGAYAVdDTCVVTSALtg-------kgAAAIAICCRSRH 668
gi 808861848 582 LENTSADKEEVEVSCPS-GWTLTDCSAVSKGSaILETVVKgNSCRVHSAAga-------dgATGVAVCCRVRP 646
gi 55153988  601 KEYSPMGFMDKVTVSCDeGWTLTGCNAYSRSSnTLGAYSIdDTCVVSNPTgg-------kgAAAIAICCQNKH 666
gi 944209716 561 KEHTSPXAVEKVTVSCDaGWTLTGCNAHSQSPgTMGAYAVxDTCVAASVPgs-------stAVAIAICCRSRQ 626
gi 326676990 595 KEHHLNTLSQQVEVSCEdSWTLTACEALSRDAvIHGAFAMgNTCVVRTSGvd-------kdAAAIATCCRNHP 660
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