2EBF,2VK9,2VKH,4ERR


Conserved Protein Domain Family
toxin_MLD

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cd16840: toxin_MLD 
Click on image for an interactive view with Cn3D
toxin effector region membrane localization domain
This domain functions as a membrane-targeting domain for toxin effectors such as the Rho-inactivation domain of Vibrio MARTX, Pasteurella mitogenic toxin (PMT), where it has been termed PMT C1 domain, and Clostridial glucosylating cytotoxins including Clostridium difficile toxins A and B, Clostridium novyi alpha-toxin, and Clostridium sordellii lethal toxin.
Statistics
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PSSM-Id: 319349
View PSSM: cd16840
Aligned: 32 rows
Threshold Bit Score: 87.3463
Threshold Setting Gi: 124377417
Created: 15-Jul-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative membrane interaction residues, 3 residue positions
Conserved feature residue pattern:[KR] S [KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:these residues may facilitate membrane interactions; based on targeted mutagenesis coupled with in vivo localization and in vitro binding studies

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                        #                                             # #               
2EBF_X         51 VWTPEVLKArASVIgKPIGESYKRILAKLQRIHNSniLDERQGLMHELMELIDLYEESQPsSERLNAFRELRTQLEKAL 129
4ERR_A          4 IFTVQELKErAKVFaKPIGASYQGILDQLDLVHQAk-GRDQIAASFELNKKINDYIAEHPtSGRNQALTQLKEQVTSAL 81
gi 81419338    71 LITSNNLRKeAAVFaKRIGPSYQEILDELEHLHHLs-GNEQLAAGFELHRRITHYLEEHPdSKRNTALRRTQTQFGDLM 148
gi 81447441  3592 IFTVQELKErAKVFaKPIGASYQGILDQLDLVHQAk-GRDQIAASFELNKKINDYIAEHPtSGRNQALTQLKEQVTSAL 3669
gi 81755413  3592 IFTVQELKErAKVFaKPIGASYQGILDQLDLVHQAk-GRDQIAASFELNKKINDYIAEHPtSGRNQALTQLKKQVTNAL 3669
gi 297628861 2974 LITKDGLRKkASVFaKPIGPAYQAILDKLDHIHNLt-GNEQLSAGFELYQRITRYLNEHPdSKRNTALSGVQTQLGDIM 3051
gi 496188266   57 VWTRDSLVQhAAVPrKLKGSSYQAILAILDALHNSs-GTQQIENALILKNQIRHYQEHHAsSERNPALIILNQQVDKEL 134
gi 500024548 3085 VYSPDELKKaAQVFaKPIGESYQQILDQLATLHGAs-GQTKIEAALRLNNLIDDYLVKYEgSGRNPALSKLQSQLHGNL 3162
gi 914730910 1661 IFSRNELKKqASVMgKPIGSSYQQILNTINIVNSTs-SSERIKNIFTLRKQVESYISKHPtSGRNKAFVTLGQKIDATL 1738
gi 917732555    4 LITRQALQQeASVFaKRIGPSYRAILDGLERLPTVg-GDTQLAEGLALHQRLSRYLAEHPtSGRNPALGRLRAQLEEKL 81

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