1J3L,1NXJ,1Q5X,1VI4,2C5Q,2PCN,3C8O,3K4I,3NOJ,5IR2


Conserved Protein Domain Family
RraA_family

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cd16841: RraA_family 
Click on image for an interactive view with Cn3D
ribonuclease activity regulator RraA family
RraA protein family is named after the regulator of ribonuclease activity A (RraA), a protein that binds to RNase E and inhibits RNase E endonucleolytic cleavages. Members also include proteins with other functions, like a 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate (HMG/CHA) aldolase from Pseudomonas putida, which catalyzes the last step of the bacterial protocatechuate 4,5-cleavage pathway and the uncharacterized YER010Cp protein from yeast, an organism lacking RNAse E.
Statistics
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PSSM-Id: 319245
View PSSM: cd16841
Aligned: 215 rows
Threshold Bit Score: 72.4921
Threshold Setting Gi: 502713539
Created: 12-Jul-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
trimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ##        #                                                                  
1J3L_A         6 TDLSDLyp--egEALPxvFKSFgg----raRFAGRVRTLRVFedna-------------lvrKVLEEegAGQVLFVDGGG 66
1Q5X_A         6 SELCDIyqe-dvNVVEplFSNFgg----raSFGGQIITVKCFedng-------------llyDLLEQngRGRVLVVDGGG 67
gi 499838943  18 ATLCTAlf--krGLRNqfIQDVrpiqsnpgTMVGEAFTLRYIparedlnpitvfqdpnhpqrQAIEQcpPGAVLVIDSRK 95
gi 501558836  17 ATITTVll--kkGLRNvwMRGTrplrpgqkRLVGPAFTLRFVparedlatpe-swskpistrTAIEAmpEGCIAVVDAMG 93
gi 503438087  17 SSVCDAdks-laVVDPa-IRPLvp----gvRLAGPAVTVVAHddhl-------------pllVAIRAaaPGSVLVVATNG 77
gi 503628376  22 TSLADAgrgvvgVLPAe-IRPVrp----glRILGTAVTVEARddlm-------------pmlAGLRLagPGDVLMVAGSS 83
gi 503812295  13 TTLADLlgr-eqVMDVg-IRPLrss---apRIAGPAFTVRCPpgdn------------lmfhAAIYRaaPGSVIVAEAGD 75
gi 503873322  15 CDLADAlpr-hqFMHYa-IHPLwan---mpRIAGRAFTAQCGhgdn------------lmlhAAIYAaePGDIIVVQAND 77
gi 504800508  16 TALCDAdks-trVLDSa-IRPRsg----avRIFGPAFTVRCTgdff-------------avlRAIETaaPGDVLVVDGGG 76
gi 506408203  27 AVVVDLgqn-lgQIDPa-IRPLlpag-rqpRLFGRAVTALCEppdf------------gavlHALDLigLGDVLVIAAGG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     ####              ####                             
1J3L_A        67 slrtALLGGNLARRAWEkGWAGVVVHGAVRDTEELREv-pIGLLALAATPKKsak-egKGEVDVPLKVlGVEVLPGSFLL 144
1Q5X_A        68 svrrALVDAELARLAVQnEWEGLVIYGAVRQVDDLEEl-dIGIQAMAAIPVGaag-egIGESDVRVNFgGVTFFSGDHLY 145
gi 499838943  96 daraASAGSILVTRLMQrGGAGIVTDGGFRDSPEIAQm-aMPAYHHRPSAPTnltlhqALEFNVPIGCgDVAVFPGDVIV 174
gi 501558836  94 itdaGIFGDILCMRMMKrGVTALVTDGVMRDVEGVLGt-gLPVWCDGAAAPPsvagltFVNWGEPIGCgGVAVFPDDVIV 172
gi 503438087  78 gt-rAVSGELFATEARRrGLAGIVVDGYCRDRAGLPAv-gLPVYARGTTPMAgtt-ldAGRIDEPVTFgGVRVEAGDLVV 154
gi 503628376  84 e--hAVAGELFGTEALRrGMAGIVIDGYCRDTRTLATl-eLPVYSRGAVPSApgassaQPVVQVPITVgGVEVCPGDIVV 160
gi 503812295  76 md-yALAGGNVCAVAQRrGIAGFVIDGVIRDLAEVREm-gFPVFARGVIPVPgtk-tsVRPLNVPVRCgGVQVHPGDIVV 152
gi 503873322  78 e--yAVSGGNVCAIAKSrGIAGFVIDGVIRDIDEVVDi-eFPVHALGTCPKPgak-kvYIPLNRPVVCgGVNVHTGDIIV 153
gi 504800508  77 se-iAFAGELFARGALVrQLGGIVIDGGYRDIAYVRSc-pLPIYSRFVTPMAgst-teLGELQIPVTCgGVPVVPGDLIL 153
gi 506408203  92 haetAMIGEIVGGQLRRrGGAGLVCDGAVRDVGTLAGwsdLPVFTRFVTPRGpas-aeRGAVNAPVVIgGALVTPGDLVI 170

                 ....*....
Feature 1          ### #  
1J3L_A       145 ADEDGLLLL 153
1Q5X_A       146 ADNTGIILS 154
gi 499838943 175 GDAEGVVVI 183
gi 501558836 173 ADEDGAVVI 181
gi 503438087 155 GDDDGLVVG 163
gi 503628376 161 GDEDGVVIA 169
gi 503812295 153 ADEEGVVVT 161
gi 503873322 154 ADNDGVAVI 162
gi 504800508 154 ADEEGVIVV 162
gi 506408203 171 GDDDGLVAL 179

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