2PKD,2IF7


Conserved Protein Domain Family
Ig_SLAM-CD84_like_N

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cd16842: Ig_SLAM-CD84_like_N 
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N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family
Ig_SLAM-CD84_like_N: The N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar domains. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.
Statistics
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PSSM-Id: 319347
View PSSM: cd16842
Aligned: 14 rows
Threshold Bit Score: 103.563
Threshold Setting Gi: 126307398
Created: 17-Aug-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1IF7_a, human NTB-A receptor dimer interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Structure:2PKD_A; human CD84 dimer interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:of the two dimerization modes suggested by the 2PKD crystal structure, the head to tail dimer is believed to be the physiologically relevant species.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            # #                                                         
2PKD_A        11 GILGESVTFPVNiqeprqvKIIAWTs---kTSVAYVTpgds--etapVVTVThrn-------yyeRIHALGp--nYNLVI 76
2IF7_A        10 GILGESVTLPLEfpagekvNFITWLfn--eTSLAFIVphet---kspEIHVTnpk-------qgkRLNFTQs---YSLQL 74
gi 151556989  49 GTLGGSVTLPLQlqdgqqvESISWVsrsvpGAIATVTlvea--ggpdTFHQEesr-------ywgRLSVVGp--dRSLQI 117
gi 126307273  36 GVLGESAILPLTipkekqiTYILWTs---kRSLAIIEmgke--gnanKTTIIdph-------ykeRVNFLKqsynYAMQI 103
gi 126307277  38 GILGESAILPADipdknkiDNINWAs---rTPVAVVTpeg----tavNIITThqn-------ykgRLNVSSk--tYDLQI 101
gi 149598934  30 GTIGGMVTFPLDipagrrvTNIDWRa---kQTIAKVSpgeagnlpklNFVLPqy---------keRLSVSTd---YSLTI 94
gi 115495559 257 GVLGESITLSLAlldsqhiDNVVWIf---nTSIISKEwr-------eEATANqliefk--dpdqnTVWVSSq--dYSLKI 322
gi 115495559  57 AIVGGSVILSLNisvdaeiEQITWSg---pKDALVLAfp-------sGEILFldks------ykgRINIPKn---NSLSI 117
gi 126307295  38 LVLGESVSLPVNieegeeiEKIIWSf---hSTLAVIQqea-----mkEPSISivpdp----rynvIVNISDh--tYSLHI 103
gi 126307398 635 GIVGGFILFPLNvsleteiQEIEWRf---kSEQLQLLs--------lKPGASsflwynpldrykeRLEILEd---SSLII 700
                         90       100       110
                 ....*....|....*....|....*....|....*
Feature 1                   # # #                   
2PKD_A        77 SDLRMEDAGDYKADINtqa--dpyTTTKRYNLQIY 109
2IF7_A        75 SNLKMEDTGSYRAQIStk----tsAKLSSYTLRIL 105
gi 151556989 118 SHLNWADAGSYRAHINlrs--srlTHTREYSLHVY 150
gi 126307273 104 NHLKMEDAGSYQAEITian--itePMKKMFTLHIH 136
gi 126307277 102 NHLKMEDAGFYRADINlktsststTITKNYTLQIY 136
gi 149598934  95 SNLRPEDAGTYRVRINtvnatsnsFTNMEFSLRVY 129
gi 115495559 323 VQLKMEHAGLYQAYLCsna---rvASVKHINLRIY 354
gi 115495559 118 NKLTLKDAGSYKARINqkg---seDFNERFILYIY 149
gi 126307295 104 SNLSKEDEGTYRAEMNfeg--fpgTITQKFILRVY 136
gi 126307398 701 RNLTPKDSGLYEARVIfns---gvFIIQTFVLSVY 732

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