1DBQ,2QU7,1JFS,1ZVV,2H0A,3CTP,3BIL,3BBL,3C3K,3BRQ,3CLK,2RGY,1JWL,1BYK,2IKS


Conserved Protein Domain Family
PBP1_LacI_sugar_binding_like

?
cd06267: PBP1_LacI_sugar_binding_like 
Click on image for an interactive view with Cn3D
Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily
Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.
Statistics
?
PSSM-Id: 107262
View PSSM: cd06267
Aligned: 697 rows
Threshold Bit Score: 46.8394
Threshold Setting Gi: 88711387
Created: 26-Dec-2007
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1BYK; Escherichia coli TreR binds trehalose-6-phosphate, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9865945
  • Structure:1JFS; Escherichia coli PurR binds hypoxanthine (corepressor), contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:3BRQ; Escherichia coli GalS binds fructose, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Structure:3CTP; Alkaliphilus metalliredigens transcription regulator binds D-Xylulofuranose, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                       ##  #                                            #               
1DBQ_A         9 SIGLLAtss---eaaYFAEIIEAVEKNCfqkgYTLILGNawnnlekqraYLSMMAQKRVDGLLVMcseypepl----lam 81  Escherichia coli
YP_996173     70 NVALIVpdv---anpFFPPLIRAVEAAAdaagMCIFLGDsdedp-areaRLVGKLSAQVDGLILAscrlaeg------ai 139 Verminephrobact...
YP_001107241  65 TITLVVtdi---anpYYAPLIKAAQSQAlekdYTLVLTDsdesp-rvevSNLRQLLATTSGAILAtsrlsdd------vi 134 Saccharopolyspo...
AAP42876      60 HLGVIVpdl---lnpFFADICKGVQARArglgLTVFVSDterde-glelDAIRTLAPQVDGIVLCsphlsgee----lgs 131 Streptomyces na...
YP_829994     83 TVAVLVpdi---tnpFYFDIIRGTQHQLkaagLTQLLVDteess-emelEALHKMRRSADGFILAasrltda------ql 152 Arthrobacter sp...
YP_702754     63 TVAVVVpdi---ghtVFASFVKAAQAQGwhrrQTVLLTDtdgsa-drerEVLGELQGRVDALVVCaprlpas------di 132 Rhodococcus sp....
NP_738986     92 IIGMVApdv---snpFFVEIFRGAEHAAaaqgMVVTLLNanest-srarTAIERITPHVDGLLLVssrmdss------ei 161 Corynebacterium...
NP_786760     82 IIGVIAthv---adyIFPQIIYGIDQVIseggYSLLLGNthnnhqrerkNLINMLNSKVAGLIIEptqsaldnpnmdlyq 158 Lactobacillus p...
AAT84034      70 LVAVCVadv---mnpVFGATVKGIFAGArkrgYMVVLIDsness-eiesETTKRSLATVDGFIFVgsrmsda------gl 139 Propionibacteri...
YP_769372     61 EVAVVFhdldavnseLYMQVQNGVQREAhrlgMTLRVRWth------dsGQLEELARTCDGLMLVgpharea------va 128 Rhizobium legum...
Feature 1                    #             #                                   #                 
1DBQ_A        82 leeyrHIPMVVMDwgeakadftdAVIDNAFEGGYMAGRYLIerghrEIGVIPGplerntGAGRLAGFMKAmeeami--kv 159 Escherichia coli
YP_996173    140 qalsgRLPIVLINrdva---gmdRVLIDSAPGVAAAVRHLHelghrCVAYLAGpasswsNERRRIAVLDTaqesg----l 212 Verminephrobact...
YP_001107241 135 rqiaqHRALVVINreid---gipSLVVDTARGMRKAVRHLAaighrRIAYLSGprnswiNSARWRAVQEEsgalg----l 207 Saccharopolyspo...
AAP42876     132 lgdftDKPIVLLHrkep---gfgSVTADLVEGMTDALTHLHalghrRIAYVGGprsswaARERAAGVEAVaasgl----v 204 Streptomyces na...
YP_829994    153 advsgSQPLVTINrasa---napTVVIDTPSAMIQALEHLAslghhRICYVSGpptswsNLRRWKIFEEDsahrg----l 225 Arthrobacter sp...
YP_702754    133 vqlagDTPLVLVNrssp---ecdCIVADSEDGIRQAIDYLValgheHLAYVQGspqswsNQRRVAAVEEFckard----v 205 Rhodococcus sp....
NP_738986    162 qkiarAVPTVVVSrpis---gipSMMVDNYDGAVKALVHLVdqgcrSITYVSGphrswsDSTRWRGIVDAatalg---tl 235 Corynebacterium...
NP_786760    159 eikdnGIPVLFINasypn-ldfqAVTTSDQEAEQRMIEYLFemgheSILGIFQvdd-aqGVHRMNGFVKAyqeqpeisyk 236 Lactobacillus p...
AAT84034     140 rhlagIKPVMTVNrkvp---gvsSVTPASDEGLGDALTHLVsegrsTVTYLAGptaswqSGVRWRSLLERarrdg---kv 213 Propionibacteri...
YP_769372    129 avsatGVPIVRFGwvdal-eqidHVGGTDHEAGQAVVEYLVglghrSIVYVYGmpglrgRQERHYGAREIaery------ 201 Rhizobium legum...
Feature 1                 #                                                                      
1DBQ_A       160 pesWIVQGDFe----------------------------pESGYRAMQQILSqph-rptAVFCggDIMAMGALCAADEMg 210 Escherichia coli
YP_996173    213 eviQIAPRRPs-----------------------------YEGGMAAATIVRstr--atAVIAfdDLVAQGLLAGMARMg 261 Verminephrobact...
YP_001107241 208 daaFVGPHVPn----------------------------lSGGHEAADALMLqr---atAAIAynDLIAIGALQRLQTAg 256 Saccharopolyspo...
AAP42876     205 eivQVGSVAPh-----------------------------FDGGVTGAADVVlas-gasAVLAfdDIVAFGLISRFTVRg 254 Streptomyces na...
YP_829994    226 ethRIGPFTPk----------------------------tTSGAAAADAAVRtg---atACIVfnDLLAIGMLQRLRERg 274 Arthrobacter sp...
YP_702754    206 qlsLLGWQQEt-----------------------------LAGGHAAAASVIatg--asAVIThnDPMAIGVMNGVRAMg 254 Rhodococcus sp....
NP_738986    236 agdQAGSASLrvsrtvtvqpsrmrhltrptvrqlpadepsLVGGRRAFGEWAkep--tdAVICfnDMVAVGFIQQAESTg 313 Corynebacterium...
NP_786760    237 sniLMYQSGDp----------------------------fEKLAHRLDTYLQnne-rptAIACynDQLAIRVMDYLKGKg 287 Lactobacillus p...
AAT84034     214 tvhQLACPTPt-----------------------------IRGGIEAFDMWRahp--tsAVIAynDLIAIGFMRRAMACg 262 Propionibacteri...
YP_769372    202 pdvSLHVMQFd----------------------------eENGFSTAFRALVekgirptAFFCahDGLALTVVSELLGQg 253 Rhizobium legum...
Feature 1                    #                #                                      
1DBQ_A       211 lrvpqdVSLIGYDNVrnaryftPALTTIHQPkDSLGETAFNMlldriv----nkreepQSIEVHPRLI 274 Escherichia coli
YP_996173    262 vhapagISVVGCDDVlat-rtyPALTTIASRpELAGRMAMEVlleqla----agkssgAAHMLNTELI 324 Verminephrobacter eiseniae ...
YP_001107241 257 isvpadFSLIGCDDIfgadlttPGLTTIAGPtERLGRSAVDVlhaqlt-----hrtrtDSTLFDAHLV 319 Saccharopolyspora erythraea...
AAP42876     255 vrvpeeMSVVGCDDIalsgmaaPPLTTVSVPkAHGARAAVDLlcrilatp-aaegeqpPQRVLPTHLV 321 Streptomyces nanchangensis
YP_829994    275 irvpedMSIVGCDDIfgadfcnPPLTTISSPiEQAGRVAVSMllsqlnp--lhggttrRLAVMPTHLT 340 Arthrobacter sp. FB24
YP_702754    255 fsvpadLSVVGIDDSplaelasPALTSINVPmARAGVLSLDLvfqran----epdsdiREIHLPTQLV 318 Rhodococcus sp. RHA1
NP_738986    314 irvpadVAVVGFDNTeisvlvsPSLSTVAGPlRSVGRVGTANliaiing--mkaplmaKPRELPTRLI 379 Corynebacterium efficiens Y...
NP_786760    288 lniptdISIVGFDDYhmsrymsPGITTMNHEkTTMGEDTGRQmlrll------hkqpvESIVYTPKLI 349 Lactobacillus plantarum WCFS1
AAT84034     263 lripndVAVIGFDDIpfsalvsPALSTVRVNqFQMGVVAVNRlldmvekpshherqapSEDVVPVSFM 330 Propionibacterium acnes KPA...
YP_769372    254 yripddISVVGFGDYspatqisPALTTVRMEgQECGAVGLRLllerienp-rlpgmpaRRIMIASRII 320 Rhizobium leguminosarum bv....

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap