Conserved Protein Domain Family
PBP1_iGluR_AMPA

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cd06380: PBP1_iGluR_AMPA (this model, PSSM-Id:107375 is obsolete and has been replaced by 380603)
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor, a member of the glutamate-receptor ion channels (iGluRs). AMPA receptors are the major mediators of excitatory synaptic transmission in the central nervous system. While this N-terminal domain belongs to the periplasmic-binding fold type I superfamily, the glutamate-binding domain of the iGluR is structurally homologous to the periplasmic-binding fold type II. The LIVBP-like domain of iGluRs is thought to play a role in the initial assembly of iGluR subunits, but it is not well understood how this domain is arranged and functions in intact iGluR. AMPA receptors consist of four types of subunits (GluR1, GluR2, GluR3, and GluR4) which combine to form a tetramer and play an important roles in mediating the rapid excitatory synaptic current.
Statistics
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PSSM-Id: 107375
Aligned: 24 rows
Threshold Bit Score: 369.717
Created: 17-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative dimerization interface [polypeptide binding site]
Evidence:
  • Comment:based on sequence similarity to mGluR

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
P42263     35 SIGGLFmrn----------------tvQEHSAFRFAVQLYNTnqntt----------------ekpfhLNYHVDHld--- 79   human
121438     25 PIGGIFdsr----------------svQALTAFRHEIHMFNRayshv-----------------yrykLKNDTTIld--- 68   great pond snail
P34299     10 MFGVLFtvfnl------------tvvqPYPSHIIIKSFGNNEevsrvalkameytsdhinsrddvpfkLAFDHRVvee-- 75   nematode
CAD58975   38 SIGSVFdve----------------seKIQTAFRFAVDRFNTiens------------------aqlkLNPLREEid--- 80   Loligo opalescens
AAP41203   12 LSGQFVtlakrkacrpqswrtrcsgrrPYAQAFDFASTVMNNnllnerr------------pgrdrtvLFPITKNftd-- 77   California sea hare
AAP41204   23 PIGIIVdvd----------------erDVITILKRMIARHNSeqtss-----------------nhiiISPSWYIan--- 66   California sea hare
AAP41207   39 PIGTLFnmd---------------aepVSRSALMYAISTNNElrkg------------------gkgiTFNMLSDdvd-- 83   California sea hare
Q10914      7 VFGFLIfvki--------------getSKKFPLRAFVASTDIdndta----------------haiieMLRLAEMtfnal 56   nematode
Q03445     41 PLGAIFeqg----------------tdDVQSAFKYAMLNHNLnvss------------------rrfeLQAYVDVin--- 83   fruit fly
ABB03887   30 PIGLIFdersp------------tlerSVLQHLREHSDNNNYf------------------------tLETQVHRld--- 70   California sea hare
Feature 1                            # ##  ##                             #                   
P42263     80 -------------------ssNSFSVTNAFCSQFSr-GVYAIFGFYdqmsmntltsFCGALHTSFVTPSFptd------- 132  human
121438     69 -------------------vtDSFAVSNALCHHLSr-GDLAIFGVSnasslatiqsYTDTFNVPFVTISMaqnn-----s 123  great pond snail
P34299     76 ------------------gaaVSWNMVNAVCDELKe-GAMALLSSVdgkgregirgVSDALEMPLVSLTAlsnddhqqqq 136  nematode
CAD58975   81 -------------------dtDSFSLGNALCSIMSk-GVFAVFGKAnssmlatvksYSDTFQIPYLTTSMamnt-----t 135  Loligo opalescens
AAP41203   78 -------------------lsDNYKLGGAICSMVNk-GVLLIVGTSrdssfntiqsYCQALQVPYILASPsrphl----f 133  California sea hare
AAP41204   67 -------------------inNNCDLIRAICQRLDa-GVFLLLGSSssrsyniiqsYSHALHVPYVVYSQnvnqp----r 122  California sea hare
AAP41207   84 -------------------idSNFAVTSKLCAQMSs-GIFVMYGSTsqstfktlqaYSAKFNMPFITPDLsgtih----k 139  California sea hare
Q10914     57 sdvdfdvllgtrdlppmematMMWNLNRIICDEMKlgYMLMLAGTNfknyg-iyedIANHMKMPLIDWEPsksenigktt 135  nematode
Q03445     84 -------------------taDAFKLSRLICNQFSr-GVYSMLGAVspdsfdtlhsYSNTFQMPFVTPWFpekvla-pss 142  fruit fly
ABB03887   71 -------------------tsDSYNVSRALCSLLSg-GAVTIIGDIrpqaldtvidYADDTQIPFIFLNNpadpkr-wsd 129  California sea hare
Feature 1                                                  #  #                    # #        
P42263    133 advQFVIQMRPALKGAILSLLGhy--kWEKFVYLYDTErgFSILQAIMEAAVQNn-------wQVTARSVGNIkdvqeFR 203  human
121438    124 hngSYQIYMRPMYINALVDVIVhy--rWEKVAFYYDSDegLVRLQQLFQATNKYdkm----iiSIDTKRITSVengyhML 197  great pond snail
P34299    137 fgnLFEVSVRPPISELLADFIVhk--gWGEVLVLIDPVhaSLHLPSLWRHLRTRtn------tSVKASMFDLPadekqFE 208  nematode
CAD58975  136 dqsPYMLFLRPINIRAIVDLIEhl--gWRVVHYIYISNegLMRVQQLFQVMGKSdl-----qmTLNVKRASDVnssyvIL 208  Loligo opalescens
AAP41203  134 sgyHFDISLTPPYISAVMKVLAnmtssSNKVFYVYDSDdgLWRLQQLYNYFQLEdsv----prALDAFRVRDVs---rAY 206  California sea hare
AAP41204  123 dgyDYDVTVSPGYVTAVAELIKff--nWEKVYYVFDSDdaLWELQRLHDYVRLPpn-----dvMIDARRLRNVt---sSH 192  California sea hare
AAP41207  140 ehqPQMLFAKPVYADAIVDLVKgl--nWRRLDYVYDNSegLLRVQHVYDRLKREqy-----giEIGFRRIEQVesaheDL 212  California sea hare
Q10914    136 ennPMIFSVAPSAEQLLIDYIQyk--gWRDVVYIHDGKnaDRTLRTMFSYLHEKsp-----kyQLFVDNYVAPsdeemFK 208  nematode
Q03445    143 gllDFAISMRPDYHQAIIDTIQyy--gWQSIIYLYDSHdgLLRLQQIYQELKPGnet----frVQMVKRIANVtmaieFL 216  fruit fly
ABB03887  130 drrSMQVYMEPSLTKAIVGMVYtw-yrWRRFYYIYDQLdsITRIEQTHDFLHEFprdyryatpDVQPHRVDGAh---qCL 205  California sea hare
Feature 1                                                                                     
P42263    204 RIIEEMDRRqe-------------------kRYLIDCev----erINTILEQVVILgkh-srGYHYMLANLGftd----- 254  human
121438    198 KELHLMDPEme-------------------hRVLLDVrt----dkAEQIILKVMNDskinnaKFHFLLGDLGmle----- 249  great pond snail
P34299    209 AYLMQFNMMrnn----------------etnRILIDCasp---krLKKLLINIRSAqfn-qaNYHYVLANYDflp----- 263  nematode
CAD58975  209 KELHHTNPEld-------------------iHAVLDMsi----pmASELMNLLSEDprvhnrRFHFLLVEPGiqe----- 260  Loligo opalescens
AAP41203  207 SLLRSLDLKdmde---------------gnkLIVLDLsse---esFKLVLEQIVDVgmn-rdNYHYILAGPDamdldlsr 267  California sea hare
AAP41204  193 DFLRQLDRFsth-----------------tkRIILNLssr---daYQKVLNQLVDVgmn-rdNYHYLLSGPYids----- 246  California sea hare
AAP41207  213 RRLDYLDREkm-------------------rNIVLDLssl---naYAALLRQIPEVgmn-rhGYNYILGTLDmls----- 264  California sea hare
Q10914    209 EFLNEFHRRistqhtlksndsseeidepipvNVIVDLegsyrtraFLRALEESVLVk----kEYHYVFSNFDvde----- 279  nematode
Q03445    217 HTLEDLGRFsk-------------------kRIVLDCpa----emAKEIIVQHVRDiklgrrTYHYLLSGLVmdnh---- 269  fruit fly
ABB03887  206 RLLLDIFENnrg----------------edvRVVLDIpp----edTQWVITQLVEDkdihkiRFHFIIPYLSlrs----- 260  California sea hare
Feature 1                                                                                     
P42263    255 illERVMHGGANITGFQIvnnenpmVQQFIQRWvrlderefp-------eaknaplkyTSALTHDAILVIaeafrylrrq 327  human
121438    250 intTHFKIGGVNITGFQLvdpfnstSELFISTWssldpvywp-------gagtnhvnyEAALAADSVRLFksafgsilqk 322  great pond snail
P34299    264 ydqEMFQNGNINISGFNIinkdgreYWSLKKHLktssslg-----------ggddvsvEAAVGHDAMLVTwhgfakclqa 332  nematode
CAD58975  261 ldfAKIGLYGYNVSGFQLvdfnnmtVRLFLSDWtkidpaewp-------gagvktityEAALAVDAVSLFtramknlsnl 333  Loligo opalescens
AAP41203  268 dffSQFLYGGVEISAFRFvdntsdtYRKWEQLWqqykdeyp----------glfplktGSAMMIDAVRAVhealmldlp- 336  California sea hare
AAP41204  247 ldlRSFLYGGVNVTGFRLpi----dLQEVTPSWarvpalele-------pllnkristDAALAADGLQLVinalndlkvs 315  California sea hare
AAP41207  265 ldvSRFLHGGVKVYGFQLvdvsrrqVQTFLEEWqelepgiwp-------gagtnllqtDAALSVDMLHTIraaltamike 337  California sea hare
Q10914    280 tdlSGFHFSLINITIFRIfd---knNKKFLKTRaefhdvyrgg------fsntdsiptAAAFAHDAILVAgkalqiamne 350  nematode
Q03445    270 wpsDVVEFGAINITGFRIvdsnrraVRDFHDSRkrlepsgqsqsqnaggpnslpaisaQAALMYDAVFVLveafnrilrk 349  fruit fly
ABB03887  261 iflESFITGGVNITGFEIf-----eEGKSLQYRrknpn----------------tikvRDHIAADTAQLLeqslmmlqrh 319  California sea hare
Feature 1                                                                                     
P42263    328 r----------------------vdvsrrgsagDCLAN--------PAVPWSQGidIERALKMVQVQGm-----TGNIQF 372  human
121438    323 dpnf----------------lrrsrsgtagksmKCTDD--------SEIKTGHGqmILEEMKKVKFEGv-----TGHVAF 373  great pond snail
P34299    333 ndslfh-----------gtfrhrrffnrgfpgiYCDPLsdrshpnrPFSSFEHGktIGVAFRNMKIGHkeg-tlTGNIEF 400  nematode
CAD58975  334 glfe---------------slfvrarsgansskTCAAE--------RLNVWNKGkhVLKAMKETEFDGl-----TGRVAF 385  Loligo opalescens
AAP41203  337 ------------------------qsirgpqtrTCDME--------NPQPSEVGpaIMTSLAKVQFEG------LTGPLA 378  California sea hare
AAP41204  316 natrhif----------ktfrhselynngtrgvQCWRH--------PPLPWVHGpvIRQALLKSNFTGi-----TGPLTI 372  California sea hare
AAP41207  338 qrdvfhy----------vfrrgkmynmnktigiQCNSN--------PPLPWMHGeqIYRALKQVDFDGl-----TGHIQF 394  California sea hare
Q10914    351 hgkgifd----------ksfvrhqlfnrgrkglYCRPHedqt-esrQFETFEHGkkIAEAIKKVVLTDkdgtltGRIQFD 419  nematode
Q03445    350 kpdqfrsnhlqrrshggsssssatgtnessallDCNTSk------gWVTPWEQGekISRVLRKVEIDGl-----SGEIRF 418  fruit fly
ABB03887  320 qgsas--------------vfgnvngwqlsqemTCLPQ--------LRWRWRYGraLAKVFQNTTFHGr-----SGYVQF 372  California sea hare
Feature 1                                            
P42263    373 DTYGRRTNYTIDVYemk-----vsgSRKAGYWNEYERFV 406  human
121438    374 NEQGHRKDFTLGVYnva-----mtrGTAKIGYWNEREGK 407  great pond snail
P34299    401 DRFGNRKNFDVSIVdlvsntkatfnSKEVLAWRQGVGFF 439  nematode
CAD58975  386 DDRGHRKEFTLDVLdigi----trgAVKIGYWTPRDGLT 420  Loligo opalescens
AAP41203  379 LRQGQRSEYKLDVYrlqf----krpMRKIETWHPEDLRE 413  California sea hare
AAP41204  373 NSHGQRVGHRLDLMqldy----rnpLRKVGSWSETLGLT 407  California sea hare
AAP41207  395 DEFGQRANYSLDIItagl----dtgLAKIGKWHSRYGLL 429  California sea hare
Q10914    420 KVTGKRTNFSAEIVeik-----pgvNSLNSIWERFQWAE 453  nematode
Q03445    419 DEDGRRINYTLHVVemsv----nstLQQVAEWRDDAGLL 453  fruit fly
ABB03887  373 DSTGQRTELSVEVQevtm----yrgLTIVGTWDKDGFQA 407  California sea hare

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