1X42,1LVH,1TE2,2PIB,2NO5,1AQ6,2B82,2I6X,2B30,2GMW,2O2X,2FPR,1QYI,2HX1,2OYC,1YS9,1YDF,3DV9,2FDR,1VJR,1PW5,2C4N,2HO4,2OM6,1ZJJ,2HSZ,1RKQ,2HOQ,3E58,3D6J,2NYV,2GFH,2HDO,2AH5,2GO7,2FI1,2ZG6,1S2O,2QLT,2HI0,2I54,2AMY,1YJ5,1XVI,1L8L,1NF2,2B0C,2IOF,1YMQ,1NRW,1WZC,3DNP,3DAO,1RLO,1WR8,2HCF,1L7O,2P9J,2PQ0,2B8E,1S8O


Conserved Protein Domain Family
HAD_like

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cd01427: HAD_like (this model, PSSM-Id:119389 is obsolete and has been replaced by 319763)
Click on image for an interactive view with Cn3D
Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, all of which use a nucleophilic aspartate in their phosphoryl transfer reaction. All members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. Members of this superfamily are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 119389
Aligned: 351 rows
Threshold Bit Score: 39.6607
Created: 13-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitemotif Imotif II
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2B82; Escherichia coli acid phosphatase AphA complexed with adenosine, phosphate, and Mg++, contacts at 3.5A.
    View structure with Cn3D
  • Comment:Mg++ is required for catalytic activity.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ###                                                                         
1X42_A        4 AVFFDFVGTLlsvegeakthlkixeevlgdyplnpktlldeyekltreafsnyagkpyrpirdieeevxrklaekygfky 83  Pyrococcus horik...
2B82_A       39 AVGFDIDDTVlfsspgfwrgkktfspesedyl-----------------------------------------------k 71  Escherichia coli
1S2O_A        5 LLISDLDNTWvgdq------------------------------------------------------------------ 18  Synechocystis sp...
1WZC_A        4 LIFLDIDKTLipgy------------------------------------------------------------------ 17  Pyrococcus horik...
3DNP_A        8 LLALNIDGALlrsng----------------------------------------------------------------- 22  Bacillus subtilis
1WR8_A        5 AISIDIDGTItypnr----------------------------------------------------------------- 19  Pyrococcus horik...
2HCF_A        6 LVLFDIDGTLlkvesxnrrvladalievygtegstgshdfsgkxdgaiiyevl----snvgleraeiadkfdkaketyia 81  Chlorobaculum te...
ZP_01617934  12 IIFTDLDGTLldqhs----------------------------------------------------------------- 26  marine gamma pro...
NP_613490     4 LVITDIDGTItgddr----------------------------------------------------------------- 18  Methanopyrus kan...
YP_504350     4 GVITDIDGTLtdekr----------------------------------------------------------------- 18  Methanospirillum...
Feature 1                                              ##                                       
1X42_A       84 penfweihlrxhqrygelypEVVEVLKSLKgk-yHVGXITDsd----tEYLXAHLDalgik--dlfdSITTseeagff-- 154 Pyrococcus horik...
2B82_A       72 npvfwekmnngwdefsipkeVARQLIDMHVrrgdAIFFVTGrsp-tktETVSKTLAdnfhipatnmnPVIFagdkp---- 146 Escherichia coli
1S2O_A       19 ----------------qaleHLQEYLGDRRgn-fYLAYATGr-----sYHSARELQkqvgl--mepdYWLTavgseiyhp 74  Synechocystis sp...
1WZC_A       18 -----------------epdPAKPIIEELKdmgfEIIFNSSkt----rAEQEYYRKele-----vetPFISengsaifip 71  Pyrococcus horik...
3DNP_A       23 ----------------kihqATKDAIEYVKkkgiYVTLVTNrh----fRSAQKIAKslk-----ldaKLIThsgayiaek 77  Bacillus subtilis
1WR8_A       20 ----------------miheKALEAIRRAEslgiPIMLVTGnt----vQFAEAASIlig-----tsgPVVAedggaisyk 74  Pyrococcus horik...
2HCF_A       82 lfrerarreditllegvrelLDALSSRSDV----LLGLLTGnfeasgrHKLKLPGIdhy------fpFGAFadd------ 145 Chlorobaculum te...
ZP_01617934  27 ----------------ysfdAANKALTSIKqrgyPLILVSSkt----lDELQQLQQqld-----itsPLVCengaaiywr 81  marine gamma pro...
NP_613490    19 ----------------avhlKCIRYLRELQkrgiPVGIATGnt----lCYSRSAATllg-----fegPLIAenggivavd 73  Methanopyrus kan...
YP_504350    19 ----------------rlstAAIETIRKLQeggiEVVLSSGnt----sCLLKGLCKlig-----tggTFIGenggvyrig 73  Methanospirillum...
Feature 1                                                                                       
1X42_A          --------------------------------------------------------------------------------     Pyrococcus horik...
2B82_A          --------------------------------------------------------------------------------     Escherichia coli
1S2O_A       75 egldqhwadylsehwqrdilqaiadgfealkpqspleqnp-------------------------------------wki 117 Synechocystis sp...
1WZC_A       72 kgyfpfdvkgkevgnyivielgirvekireelkkleniyglkyygnstke-----------------eiekftgmppelv 134 Pyrococcus horik...
3DNP_A       78 idapffekrisddhtfnivqvlesyqcnirllhekysignkkkvnsnllgkalihpsdpifypvqfveslsdllxdepvs 157 Bacillus subtilis
1WR8_A       75 kkriflasmdeewilwneirkrfpnartsytmpdrr-------------------------------------------- 110 Pyrococcus horik...
2HCF_A          --------------------------------------------------------------------------------     Chlorobaculum te...
ZP_01617934  82 edgklckqlfgpprqqllqeihrlrqdygyrfrgfadcsleeisaltg----------------------lnnddarraa 139 marine gamma pro...
NP_613490    74 deeistvpeedieliqeayrelrrrlgvrrteppglr------------------------------------------- 110 Methanopyrus kan...
YP_504350    74 fqgsmqvmanrdiavkalnlleeyygkkgirlelysh------------------------------------------- 110 Methanospirillum...
Feature 1                                                                                       
1X42_A      155 ----------------------------------------kphpriFELALKKAgvk----------geeAVYVGDNpvK 184 Pyrococcus horik...
2B82_A      147 ------------------------------------------gqntKSQWLQDKn--------------iRIFYGDSd-N 169 Escherichia coli
1S2O_A      118 syhldpqacptvidqltemlketgipvqvifssgkdvdllpqrsnkGNATQYLQqhlam-------epsqTLVCGDSg-N 189 Synechocystis sp...
1WZC_A      135 plamereysetifewsrdgweevlveggfkvtmgsrfytvhgnsdkGKAAKILLdfykr------lgqieSYAVGDSy-N 207 Pyrococcus horik...
3DNP_A      158 apvievytehdiqhditetitkafpavdvirvndeklnivpkgvskEAGLALVAselgl-------sxddVVAIGHQy-D 229 Bacillus subtilis
1WR8_A      111 --aglvimretinvetvreiinelnlnlvavdsgfaihvkkpwinkGSGIEKASeflgi-------kpkeVAHVGDGe-N 180 Pyrococcus horik...
2HCF_A      146 -------------------------------------------aldRNELPHIAlerarrxtganyspsqIVIIGDTe-H 181 Chlorobaculum te...
ZP_01617934 140 hrtftepllwddteqrylqfteqlaargfciqqggrfrtvmgdydkGGALNEVKkimgl------ersvvTIALGDSp-N 212 marine gamma pro...
NP_613490   111 rtevaiyrdvpieevervldglgysgrievvdtgfayhlkskrvdkGKGLLVICerlgi-------dpddVVAIGDGd-N 182 Methanopyrus kan...
YP_504350   111 -qerysdiafarevpveevrsllsgwpvdimdtnfaihiheagidkGRTFHIVAeqlgi-------kpdeFLGIGDSe-N 181 Methanospirillum...
Feature 1                      
1X42_A      185 DCGGSKnlgXTSILL 199 Pyrococcus horikoshii
2B82_A      170 DITAARdvgARGIRI 184 Escherichia coli
1S2O_A      190 DIGLFEt-sARGVIV 203 Synechocystis sp. PCC 6803
1WZC_A      208 DFPMFEv-vDKVFIV 221 Pyrococcus horikoshii
3DNP_A      230 DLPXIEl-aGLGVAX 243 Bacillus subtilis
1WR8_A      181 DLDAFKv-vGYKVAV 194 Pyrococcus horikoshii
2HCF_A      182 DIRCAReldARSIAV 196 Chlorobaculum tepidum
ZP_01617934 213 DQAMLNn-aDVAVVI 226 marine gamma proteobacterium HTCC2143
NP_613490   183 DAPLLKa-aGLGVAP 196 Methanopyrus kandleri AV19
YP_504350   182 DIGMIKa-aGTGCCV 195 Methanospirillum hungatei JF-1

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