2I1A


Conserved Protein Domain Family
RP_DDI
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cd05479: RP_DDI 
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RP_DDI; retropepsin-like domain of DNA damage inducible protein.
The family represents the retropepsin-like domain of DNA damage inducible protein. DNA damage inducible protein has a retropepsin-like domain and an amino-terminal ubiquitin-like domain and/or a UBA (ubiquitin-associated) domain. This CD represents the retropepsin-like domain of DDI.
Links
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Statistics
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PSSM-Id: 133146
Aligned: 32 rows
Threshold Bit Score: 155.788
Created: 15-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic motifCatalytic
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic motif [active site]
Evidence:
  • Comment:conserved catalytic motif DT/SG of retropepsin.
  • Citation:PMID 7664111
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        ###                                             
2I1A_A        11 RNAIEYTPEMFTQVPMLYINIEINnYPVKAFVDTGAQTTIMSTRLAKKTglsRMIDKRFIGEARGVGt-GKIIGRIHQAQ 89  baker's yeast
XP_764698    183 MSAQNYFPESFGRIVMLYIKVEINnVVVKALVDTGAQNTIMSKECALQCnllSLVDERFKGVAVGVGs-TKTLGKIHLAD 261 Theileria parva...
AAC24668      26 ANALEYTPEAFAKVTMLYVPCTINqVLVKAFVDSGAQNSIMNKRTAERCglmRLVDVRMRGVAVGVGr-QEICGRIHMTP 104 Leishmania majo...
XP_803743    150 ANALEFAPEAFTRVSMLHVTVEINkVKVKALVDCGAQTSVVSAATAERCginWLVDKRAVGTVHGVGe-QRSLGRIHLTQ 228 Trypanosoma bru...
XP_820363    216 ESAYEFMPELFVRVPMLFVNCEVNkVMVKAFIDSGAQRSIMNLRTAEKCglmRLLDTRAKGIMRGVGv-RRTLGVVHMAM 294 Trypanosoma cru...
EDP32935     207 QFAMEHMPEAYIPVSMLYIKMKINgVEVKAFVDSGAQVSILSDSVAQRCnlmRLVDQRFQATVHGVGgaQQLLGKIHACQ 286 agent of lympha...
XP_001324059 108 QYAYENNPENFIVYSSPFIKCSINgVEVVALIDTGAQSSIIPHALAKKCnvkYLIDARYRTLTKGVGm-QTSKGVIHGLN 186 Trichomonas vag...
XP_001710113  98 EINKYYPGLLVNAVPSLYIRVSINgTPVVCVIDTGAEFNSMGRKTARACgleGHIDTRYAGRAIGVGs-TRMLGRIHICL 176 Giardia lamblia...
XP_001709567 105 QVYDHYPELLVNNTNSVYIHIELNgHPDIAVIDTGAEFSTISLETAIRCgleDHIDKRQEGKALGIGs-SKIVGKIHLVQ 183 Giardia lamblia...
EDS88818      24 KVLEKEHPELLVKGELVFIKVKINgVVKEAMIDCGAQETVISIRACKECnleTQIDYRVKKMYQGVGr-METIGVIHLVP 102 Entamoeba histo...

Feature 1                                                       
2I1A_A        90 VKIETQYIPCSFTVLdt---diDVLIGLDMLKRHLACVDLKENVLRI 133 baker's yeast
XP_764698    262 MKIGSIFIPVSFIVIdga--nlEFILGLDILRRYTCDINLKYNYLGI 306 Theileria parva strain Muguga
AAC24668     105 VNLAGMYIPFAFYVIedq--amDLIIGLDQLKRHQMMIDLKHNCLTI 149 Leishmania major strain Friedlin
XP_803743    229 ANLGGLFIPISLVVLese--tfDLIIGLDQMKKHRMIIDLKDDCLRV 273 Trypanosoma brucei TREU927
XP_820363    295 VNLGGLHIPLSLSIIedd--kmEFIIGLDQLKLHRMIIDLRENCLRI 339 Trypanosoma cruzi strain CL Brener
EDP32935     287 VQIEEQFFSCNFDVLanr--diDVLLGLDILKRHRCVIDLQINCLRF 331 agent of lymphatic filariasis
XP_001324059 187 VKVGNEVWTNRFVVLddt--ldHAILGIDWLKKNRALIDLAQNCLIL 231 Trichomonas vaginalis G3
XP_001710113 177 MQCGDIFLPMNFAVLds---vcDTLIGMSALSMYRAMIDLSSFSMTL 220 Giardia lamblia ATCC 50803
XP_001709567 184 LKYGDEYFATNFMVVen---vvGTLLGMPFLRMHRMVIDLAIYQIRI 227 Giardia lamblia ATCC 50803
EDS88818     103 IIIGNTYCITTLNVLgddspldHLLIGTNTLKSIGAVIDFSEGVLRI 149 Entamoeba histolytica HM-1:IMSS

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