1LEH,1B26,1C1X,1EE9,1HRD,1QR6,1VL6,1DIA,1GPJ,1LUA,1NPD,1LLQ


Conserved Protein Domain Family
NAD_bind_amino_acid_DH

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cd05191: NAD_bind_amino_acid_DH 
Click on image for an interactive view with Cn3D
NAD(P) binding domain of amino acid dehydrogenase-like proteins
Amino acid dehydrogenase(DH)-like NAD(P)-binding domains are members of the Rossmann fold superfamily and are found in glutamate, leucine, and phenylalanine DHs (DHs), methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Statistics
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PSSM-Id: 133449
View PSSM: cd05191
Aligned: 14 rows
Threshold Bit Score: 38.5125
Threshold Setting Gi: 24986158
Created: 1-Jun-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD(P) binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         ###                             ##            
1LEH_B      149 VTAYGVYRGMKAAakeafgsdsleGLAVSVQGL-GNVAKALCKKLNte-----------gaKLVVTDVnkaavsaavaee 216
1B26_F      188 ATGRGVKVCAGLAmdvlg--idpkKATVAVQGF-GNVGQFAALLISqel---------gskVVAVSDSrggiynpegfdv 255
1C1X_B      152 TTAVGVFEAMKATvahrg-lgsldGLTVLVQGL-GAVGGSLASLAAea-----------gaQLLVADTdtervahavalg 218
1HRD_A      208 ATGYGSVYYVEAVmkhen--dtlvGKTVALAGF-GNVAWGAAKKLAelg----------akAVTLSGPdgyiydpegitt 274
1QR6_A      282 GTAAVALAGLLAAqkvis--kpisEHKILFLGA-GEAALGIANLIVxsxvenglseqeaqkKIWXFDKygllvkgrkaki 358
gi 24986158 118 AAGAVAARWLARQd----------SEEVALLGA-GEQAELQLKALLlvr---------dikRVRVWARssakaqqlalql 177
gi 29894603 113 ALSGVATKYLARHn----------AKTLCIIGT-GEQAKGIAEAIFavr---------dieKVILYNRteekayafaqyi 172
1DIA_A      147 CTPKGCLELIKETgvp------iaGRHAVVVGRsKIVGAPMHDLLLwn-----------naTVTTCHSktahld------ 203
1GPJ_A      149 SIGSAAVELAERElgs------lhDKTVLVVGA-GEMGKTVAKSLVdrg----------vrAVLVANRtyeravelardl 211
1NPD_A      106 TDGTGHIRAIKESgfd------ikGKTXVLLGA-GGASTAIGAQGAieg----------lkEIKLFNRrdeffdkalafa 168
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                    ##                             # 
1LEH_B      217 ga-------------------------davapnaiygvtcDIFAPCAlgavlndf---------tipqlkakVIAGSA 260
1B26_F      256 eelirykkeh--------gtvvtypkgeritneelleldvDILVPAAlegaihag---------naerikakAVVEGA 316
1C1X_B      219 h--------------------------tavaledvlstpcDVFAPCAmggvitte---------vartldcsVVAGAA 261
1HRD_A      275 eekinymlemrasgrnkvqdyadkfgvqffpgekpwgqkvDIIMPCAtqndvdleqa------kkivannvkYYIEVA 346
1QR6_A      359 dsyqepft------------hsapesipdtfedavnilkpSTIIGVAgagrlftpdvi----raxasinerpVIFALS 420
gi 24986158 178 sslyg-------------------leataaesvdeamssaDIAVTCTpsnqpilhrr-----hlrpglhitaMGADTE 231
gi 29894603 173 qekfg-------------------kpayvykdpneavreaDIIVTTTnattpvfse-------ilqkgvhvnAVGSFR 224
1DIA_A      204 ----------------------------------eevnkgDILVVATgqpemvkg----------ewikpgaIVIDCG 237
1GPJ_A      212 gge-----------------------avrfdelvdhlarsDVVVSATaaphpvihvddvrealrkrdrrspiLIIDIA 266
1NPD_A      169 qrvnentdc-----------vvtvtdladqqafaealasaDILTNGTkvgxkplenesl--vndisllhpglLVTECV 233

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