1EV2


Conserved Protein Domain Family
Ig3_FGFR
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cd04974: Ig3_FGFR (this model, PSSM-Id:143175 is obsolete and has been replaced by 409363)
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Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
Ig3_FGFR: third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR). Fibroblast growth factors (FGFs) participate in morphogenesis, development, angiogenesis, and wound healing. These FGF-stimulated processes are mediated by four FGFR tyrosine kinases (FGRF1-4). FGFRs are comprised of an extracellular portion consisting of three Ig-like domains, a transmembrane helix, and a cytoplasmic portion having protein tyrosine kinase activity. The highly conserved Ig-like domains 2 and 3, and the linker region between D2 and D3 define a general binding site for FGFs.
Links
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Statistics
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PSSM-Id: 143175
Aligned: 13 rows
Threshold Bit Score: 119.059
Created: 15-Feb-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1EV2_A; Fiboblast Growth Factor 2 (FGF2) complexed with the Ig-like domains D2 and D3 of FGF receptor 2 (FGFR2), contacts based on 3.5 A distance.
    - View structure with Cn3D
  • Comment:The Ig-like domains D2 and D3 and the loop that connects them define the general binding site.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #    ###                                     ##   #   #               
1EV2_E        125 GGDVEFVCK-VYSDAQPHIQWIKHvekngsk---------ygpdglPYLKVLKaaGVNTTDKEIEVLYIrnvt------- 187  human
BAE24286      290 GSDVEFHCK-VYSDAQPHIQWLKHvevngsk---------vgpdgtPYVTVLKvgSIPGWWLAGWVDQLgqp-------- 351  house mouse
AAO45659      255 GSDVEFECK-VFSDPQPHIQWLKHievngsr---------ygpdglPYVRALKavPPTQLPNQTYLEVLiy--------- 315  zebrafish
XP_783945     288 GGTTSFQCR-VRSDIKPHIQWLKRvethstptnatiemdgqyfvvlPAGDVLPr-PDGSYLNKLIISYAts--------- 356  purple urchin
O42127        257 GSDVEFHCK-VYSDAQPHIQWLKHvevngsk---------ygpdgdPYVSVLQs-FINGTEVDSTLSLKnvt-------- 317  African clawe...
Q4H3K6        191 GSTVTFRCRiVYSDAHPHVEWLKYn---------------------VNVTVLKraGINTTDAEMEKLTLknvs------- 242  Ciona intesti...
116097        262 GSNVEFHCK-VYSDAQPHIQWLKHvevngsk---------ygpdgtPYVTVLKtaGVNTTDKELEILYLrnvt------- 324  chicken
NP_075254     268 GSDVEFHCK-VYSDAQPHIQWLKHvevngsk---------vgpdgtPYVTVLKvsLESNASMSSNTPLVria-------- 329  human
CAM13574      259 GSDVEFECK-VFSDPQPHIQWLKHievngsr---------ygpdglPYVRALKvsVDSSSSMHSGGMLVrpsrl------ 322  zebrafish
BAD96846      179 GSNVEFMCK-VYSDPQPHIQWLKHievngsk---------igpdnlPYVQILKviMAPVFVGQSTGKETtvsg------- 241  human
NP_001024726  407 NDTATFHCK-VVSDLLPHIIWVRInkings----------ysyynnSAEEYMFnyTEMDTFDKAHVHHVgdestltifnv 475  nematode
P22182        266 GTTAEFSCK-VYSDPQPHIQWLRHieingsr---------vasdgfPYVEILKtaGVNTSDKDMEVLHLrnvt------- 328  African clawe...
Q8JG38        271 GQDAKFVCK-VYSDAQPHIQWLQHytkngsc---------cgpdglPYVRVLKtaGVNTTDKEIEVLYLpnvt------- 333  zebrafish

Feature 1                      #                
1EV2_E        188 -fedAGEYTCLAGNSi--GISFHSAWLTVL 214  human
BAE24286      352 --wpWPICPSWLKDMl--GFTKVLELLRRG 377  house mouse
AAO45659      316 --cvGFFLICVMVGTavlAKMHSSAKKSDF 343  zebrafish
XP_783945     357 --ddAGMYICLGANTm--GYSFKSAFLEVF 382  purple urchin
O42127        318 -etnEGQYVCRANNFi--GVAEASFWLHIY 344  African clawed frog
Q4H3K6        243 -fadAGEYTCLAGNSi--GVSHVSAWLTVL 269  Ciona intestinalis
116097        325 -fedAGEYTCLAGNSi--GFSHHSAWLTVL 351  chicken
NP_075254     330 -rlsSGEGPTLANVSeleLPADPKWELSRA 358  human
CAM13574      323 sssgSPMLSGVSEYE---LPQDPRWEVQRD 349  zebrafish
BAD96846      242 aqvpVGRLSCPRMGSf-lTLQAHTLHLSRD 270  human
NP_001024726  476 slddQGIYACLSGNSl--GMSMANATLTVN 503  nematode
P22182        329 -fedAGQYTCLAANSi--GISHHSAWLTVL 355  African clawed frog
Q8JG38        334 -fedAGEYTCLAGNSi--GISYHTAWLTVH 360  zebrafish

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