1OVZ,1P6F,2D3V,1OLL,1M4K


Conserved Protein Domain Family
Ig_FcalphaRI
?
cd05711: Ig_FcalphaRI (this model, PSSM-Id:143188 is obsolete and has been replaced by 409376)
Click on image for an interactive view with Cn3D
Immunoglobulin (IG)-like domain of of FcalphaRI
IG_FcalphaRI : immunoglobulin (IG)-like domain of of FcalphaRI. FcalphaRI (CD89) is an IgA-specific receptor that is expressed on monocytes, eosinophils, neutrophils and macrophages. FcalphaRI mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst. Both monomeric and dimeric IgA can bind to FcalphaRI, and monomeric or dimeric IgA immune complexes can activate phagocytosis and other immune responses through the clustering of FcalphaRI. The Fc RI ectodomain is comprised of two Ig-like domains oriented at about 90 degree to each another.
Links
?
Statistics
?
PSSM-Id: 143188
Aligned: 9 rows
Threshold Bit Score: 137.573
Created: 12-Sep-2007
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
IgA interfacehomodimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:IgA interface [polypeptide binding site]
Evidence:
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  #                 # #                              
1OVZ_A    104 KPFLSAdrglvlmpGENISLTCSsahipfDRFSLAKegel--slpqHQSGeh-------pANFSLGPvdlnVSGIYRCYG 174 human
1P6F_A    102 TPTLSVhpgpevisGEKVTFYCRldt-atSMFLLLKegrs---shvQRGYgk------vqAEFPLGPvttaHRGTYRCFG 171 human
2D3V_A    100 KPTLSAlpspvvtsGENVTLQCGsrl-rfDRFILTEegdh---klsWTLDsqltpsgqfqALFPVGPvtpsHRWXLRCYG 175 human
1OLL_A     99 TPTLSVhpgpevisGEKVTFYCRldt-atSMFLLLKegrs---shvQRGYgk------vqAEFPLGPvttaHRGTYRCFG 168 Escherichia coli
1M4K_A      7 KPSLLAhpgplvksEETVILQCWsdv-rfEHFLLHRegky---kdtLHLIgehhd-gvskANFSIGPmmqdLAGTYRCYG 81  human
P83556    121 KPFLIApqtplansGENVTLECHsei-mfDTYILTShrmeilketlQHFQeshf--sgsyASFTIGPmtpdHSGTYTCYG 197 Norway rat
P43630     28 KPFLSArpstvvprGGHVALQCHyrr-gfNNFMLYKed-------rSHVPifhg--rifqESFIMGPvtpaHAGTYRCRG 97  human
P83556     28 KPFLCAspsyivpqGQNVTLICDshs-kpNIFKVYKedg----fpiLQLHekt-----ftKSLDIGPvtpeYAGTYRCFH 97  Norway rat
BAD12825  123 KPSLLAqpsplvqsGQNVTLKCCsei-vfDSFILHRegvm---espLHLVgqfhd-ggsqATFFLGPvtiaHAGTYRCFG 197 horse

Feature 1     #                   
1OVZ_A    175 WynrspylWSFPSNALELVV 194 human
1P6F_A    172 Synn--haWSFPSEPVKLLV 189 human
2D3V_A    176 SrrhilqvWSEPSDLLEIPV 195 human
1OLL_A    169 Synn--haWSFPSEPVKLLV 186 Escherichia coli
1M4K_A     82 SvthspyqLSAPSDPLDIVI 101 human
P83556    198 AynhslyeWSDSSDPVDIKI 217 Norway rat
P43630     98 SrphsltgWSAPSNPLVIMV 117 human
P83556     98 Hqyp--neISAHSEPLKIII 115 Norway rat
BAD12825  198 SinyssyeWSTPSDPLNIKI 217 horse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap