1XED,2OCW,1ZOX,2OCW,2OCW,2OCW,2Q87,2NMS,1HKF


Conserved Protein Domain Family
Ig_pIgR_like

?
cd05716: Ig_pIgR_like (this model, PSSM-Id:143193 is obsolete and has been replaced by 409381)
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
Ig_pIgR: Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their c-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620 residue extracellular region, a 23 residue transmembrane region, and a 103 residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK Cell Receptor Nkp44 and myeloid receptors, among others.
Statistics
?
PSSM-Id: 143193
View PSSM: cd05716
Aligned: 32 rows
Threshold Bit Score: 73.2469
Threshold Setting Gi: 189515365
Created: 16-Aug-2007
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
CDR1-dIgA
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:CDR1-dIgA binding residues [polypeptide binding site]
Evidence:
  • Comment:Identified via mutation studies of the CDR1 region. Point mutations of these residues and others in the neighboring non-conserved CDR1 reduce or abolish binding to dIgA.
  • Comment:In addition to CDR1, the other two CDR loops appear to be involved in the interaction with antibody.
  • Citation:PMID 7989333

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                  ###                                                    
1XED_A          9 EVNSVEGNSVSITCYyppts-vnrhTRKYWCrqgarggcitli--ssegyvsskyagRANLTNFpe--------ngTFVV 77   human
2OCW_A        340 VVKGVAGSSVAVLCPynrk---eskSIKYWClwegaqngrcpllvdsegwvkaqyegRLSLLEEpg--------ngTFTV 408  human
P01832        356 VLKGFPGGSVTIRCPynpkrsdshlQLYLWEgsqtrhllvds----geglvqkdytgRLALFEEpg--------ngTFSV 423  rabbit
XP_001235077  246 FLHGRLGGSLSLRCHhnpv---gsyTTKYLCrwqeascsllvd--tdgfvhesykgrIWISNSEqd--------sgTYTV 312  chicken
XP_001235077  136 LHLGELRGSITIPCPpgds---wggTRRLWCrvgrsrciliad---tdgyvgksyegRICITPQes--------sgAFKV 201  chicken
AAQ14493      257 TIFGVKGSSATIDCHydpt---knySLKYLCkwrttgcariid---ntgflpgpyegRVAMFDNpk--------ngTFSI 322  chicken
CAH19212       21 LISGHRGERLDIRCPyksg---yesNPKYFCkgkcnygykni----vvksgspakdeRFSLTDDkr--------srVFTI 85   common carp
CAF89861      160 AQTVKTAAGETVPCDpprw---gamSELFFCkensntcaem-------lstrssertIGSFTLKet--------dgNFSI 221  Tetraodon nig...
XP_695421     374 PVVRREGESAQIFCPydsi---yqsKSKSLCkgkcstrdtrp-----ldetvreekeRLTLHEDvt--------asVFTG 437  zebrafish
XP_695421     111 TESVHLGGEVKISCQip------eeQKVLFCkeeynq---------------scqktRASEDPQltragsvggeerVFTV 169  zebrafish
Feature 1                                                 
1XED_A         78 NIAqlsQDDSGRYKCGLGins---------rglSFDVSLE 108  human
2OCW_A        409 ILNqltSRDAGFYWCLTNgdt---------lwrTTVEIKI 439  human
P01832        424 VLNqltAEDEGFYWCVSDdde----------slTTSVKLQ 453  rabbit
XP_001235077  313 VMShlrEEDAGWYWCVARnrh---------rehTTSMKLR 343  chicken
XP_001235077  202 LINdlrLDDAGLYKCGMGspadwd----swqlvALQVTTV 237  chicken
AAQ14493      323 VLNqlsSRDEGFYWCMTDdhre--------rrtSKELKIV 354  chicken
CAH19212       86 SITdlrTEDEGQYWCVVKktlftt---dvyteiLLLVKQD 122  common carp
CAF89861      222 FISqasSRDNGVYWCASKtelyra----glqkiTIKVKDR 257  Tetraodon nigroviridis
XP_695421     438 TITgltAEDAGKYWCAVTldrel-----nylytHLMVIIK 472  zebrafish
XP_695421     170 SISnvsVRDAGVYWCGAEtrdthltfislttkiQLSVITK 209  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap