cd05774: Ig_CEACAM_D1 (this model, PSSM-Id:143251 is obsolete and has been replaced by 409430)
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
IG_CEACAM_D1: immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions, it is a cell adhesion molecule, and a signaling molecule that regulates the growth of tumor cells, it is an angiogenic factor, and is a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain.
Structure:1L6Z_A, Mus musculus sCEACAM1a bound with mouse hepatatitis virus (MHV), defined by crystallographic and mutational analysis. - View structure with Cn3D
Comment:The CC' loop in the N-terminal Ig-like domain [D1] of sCEACAM1a, gnttaid, is involved in binding of MHV and other ligands.
Comment:An Ile residue of sCEACAM1a [D1] is a key virus binding residue on the CC' loop, however this residue and others in the loop are not highly conserved in this group.
Jiyao W et al.(2023). "The conserved domain database in 2023.",