1O0V,1O0V


Conserved Protein Domain Family
IgC_CH2_IgE

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cd05847: IgC_CH2_IgE 
Click on image for an interactive view with Cn3D
CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin E (IgE)
IgC_CH2_IgE: The second constant domain of the heavy chain of immunoglobulin E (IgE). The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) and three (in alpha, delta, and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). The different classes of antibodies vary in their heavy chains; the IgE class has the epsilon type. This domain (Cepsilon2) of IgE is in place of the flexible hinge region found in IgG.
Statistics
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PSSM-Id: 143255
View PSSM: cd05847
Aligned: 10 rows
Threshold Bit Score: 132.529
Threshold Setting Gi: 104089
Created: 21-Dec-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
IgC dimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:IgC dimer interface [polypeptide binding site]
Evidence:
  • Structure:1O0V; human IgE-Fc chains A and B, C epsilon 2A/C epsilon 2B interface, based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Human IgE-Fc is a disulfide-linked dimer of 3 domains: C epsilon 2- C epsilon 3- C epsilon 4.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ####             #                                                             
1O0V_A        13 VKILQSScdggghfpptIQLLCLVSGYTPgTIQITWLEDGqvm-dvdLSTASTTQEge-lASTQSELTLSQKHWLSDrTY 90  human
1O0V_B        13 VKILQSScdggghfpptIQLLCLVSGYTPgTIQITWLEDGqvm-dvdLSTASTTQEge-lASTQSELTLSQKHWLSDrTY 90  human
AAX73306     108 VKLFHSScnplgdthttIQLLCLISGYVPgDMEVIWLVDGqkatnmfPYTAPGTQEgn-vTSTHSELNITQGEWVSQkTY 186 giant panda
CAA30161     180 VQVLHPSsctps-qsesVELLCLVTGFSPaSAEVEWLVDGvgg-llvASQSPAVRSgs-tYSLSSRVNVSGTDWREGkSY 256 chicken
NP_001083154 255 VEILQGPcas----sesVELLCLITGYAPsEIKVQWLLNGqvteispSNSKPCKEEnd-tFSSRSKVSVPKEDWNSGdSY 329 African clawed ...
B46529       252 VQVLHSSvcstl-gddsVELLCVITGFSPpPVEVEWLVDGapahlvaTMTRPQREAgsktYMATSQTNVSREDWKAGkAF 330 mallard
ABG72685     110 VRLLHSScnrns-ddatIQLVCLISGFYPsTVTVNWLVDGqsgmlpaHTEDPKKDAsgdtFSTTSTANITQLEWKEGkTY 188 Eublepharis mac...
S31436       113 VQVLQSScadtd-gngsIELVCLISGYTPdNIQVRWLVNDkmapiqgQTSPPQKDGqg-tFSTTSQINVTKSDWASGdKY 190 axolotl
S38864       235 VFIFPPKpkdvl-trstIQLYCFIYGHILnDVSVSWLMDDreitdtlAQTVLIKEEgk-lASTCSKLNITEQQWMSEsTF 312 house mouse
S04845       242 VEILQGPcas----sksVELLCLITGYAPsEIKVHWLLNGqvtnispSNSKPCKEEng-tFSSRSKVSVPKEDWNSEdSY 316 African clawed ...
Feature 1                       ###
1O0V_A        91 TCQVTYqgh--tfEDSTK 106 human
1O0V_B        91 TCQVTYqgh--tfEDSTK 106 human
AAX73306     187 TCQVVYqgl--tfNANAR 202 giant panda
CAA30161     257 SCRVRHpatntvvEDHVK 274 chicken
NP_001083154 330 TCKVTHpashtktEASTK 347 African clawed frog
B46529       331 TCRVKHpatggtaQGHAR 348 mallard
ABG72685     189 TCQVIHqgs--tvERNAT 204 Eublepharis macularius
S31436       191 TCKVEHpatssraEDTIH 208 axolotl
S38864       313 TCKVTSqgv--dyLAHTR 328 house mouse
S04845       317 TCKVTHpashtktEASTK 334 African clawed frog

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