1EV2


Conserved Protein Domain Family
Ig3_FGFR-2

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cd05858: Ig3_FGFR-2 (this model, PSSM-Id:143266 is obsolete and has been replaced by 409444)
Click on image for an interactive view with Cn3D
Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
Ig3_FGFR-2-like; domain similar to the third immunoglobulin (Ig)-like domain of human fibroblast growth factor receptor 2 (FGFR2). Fibroblast growth factors (FGFs) participate in morphogenesis, development, angiogenesis, and wound healing. These FGF-stimulated processes are mediated by four FGFR tyrosine kinases (FGRF1-4). FGFRs are comprised of an extracellular portion consisting of three Ig-like domains, a transmembrane helix, and a cytoplasmic portion having protein tyrosine kinase activity. The highly conserved Ig-like domains 2 and 3, and the linker region between D2 and D3 define a general binding site for FGFs. FGFR2 is required for male sex determination.
Statistics
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PSSM-Id: 143266
Aligned: 5 rows
Threshold Bit Score: 150.084
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
polypeptide
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide ligand binding site [polypeptide binding site]
Evidence:
  • Structure:1EV2_A; Fiboblast Growth Factor 2 (FGF2) complexed with the Ig-like domains D2 and D3 of FGF receptor 2 (FGFR2), contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:The Ig-like domains D2 and D3 and the loop that connects them define the general binding site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #    ###                            ##   #   #                    #   
1EV2_E    125 GGDVEFVCK-VYSDAQPHIQWIKHvekngskygpdglPYLKVLKaaGVNTTDKEIEVLYIrnvtfedAGEYTCLAGNSIG 203 human
116097    262 GSNVEFHCK-VYSDAQPHIQWLKHvevngskygpdgtPYVTVLKtaGVNTTDKELEILYLrnvtfedAGEYTCLAGNSIG 340 chicken
Q8JG38    271 GQDAKFVCK-VYSDAQPHIQWLQHytkngsccgpdglPYVRVLKtaGVNTTDKEIEVLYLpnvtfedAGEYTCLAGNSIG 349 zebrafish
P22182    266 GTTAEFSCK-VYSDPQPHIQWLRHieingsrvasdgfPYVEILKtaGVNTSDKDMEVLHLrnvtfedAGQYTCLAANSIG 344 African clawed frog
Q4H3K6    191 GSTVTFRCRiVYSDAHPHVEWLKYn------------VNVTVLKraGINTTDAEMEKLTLknvsfadAGEYTCLAGNSIG 258 Ciona intestinalis
Feature 1                
1EV2_E    204 ISFHSAWLTVL 214 human
116097    341 FSHHSAWLTVL 351 chicken
Q8JG38    350 ISYHTAWLTVH 360 zebrafish
P22182    345 ISHHSAWLTVL 355 African clawed frog
Q4H3K6    259 VSHVSAWLTVL 269 Ciona intestinalis

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