Conserved Protein Domain Family
Ig_PDGFR-alphabeta
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cd05861: Ig_PDGFR-alphabeta (this model, PSSM-Id:143269 is obsolete and has been replaced by 409447)
Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
Ig_PDGFR-alphabeta: immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b). PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,-B, and C). PDGFRalpha binds to all three PDGFs, whereas the PDGFRbeta binds only to PDGF-B. PDGFRs alpha and beta have similar organization: an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFRalpha and PDGFRbeta are essential for normal development.
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Statistics
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PSSM-Id: 143269
Aligned: 4 rows
Threshold Bit Score: 141.149
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
129890  228 GENITLMCIVIgneVVNFEWTYPRKesgrlvepvtdflldmpyhIRSILHIPSAeleDSGTYTCNVTESvndHQDEKAIN 307  human
P79749  233 GEPLTVNCTVQgveLVLFSWDIPNRdivkhkpe---tvvlsattMRSCLVFPHAtvaHSGTYVCHAHEStqdQKAFASVN 309  torafugu
129895  231 GETIAIDCIVLdneVVDLKWTYPGKqrgvgirnv-eeskvpyqrLVYTLTLANAtteDSGEYECAVIHAtldNRVVKKTN 309  African clawed frog
129892  228 GETIVVTCAVFnneVVDLQWTYPGEvkgkgitml-eeikvpsikLVYTLTVPEAtvkDSGDYECAARQAtreVKEMKKVT 306  human

129890  308 ITVVE 312  human
P79749  310 ITVLE 314  torafugu
129895  310 ITVHE 314  African clawed frog
129892  307 ISVHE 311  human
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