cd05865: Ig1_NCAM-1 (this model, PSSM-Id:143273 is obsolete and has been replaced by 409451)
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
Ig1_NCAM-1: first immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1. NCAM-1 plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-nonNCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves the Ig1, Ig2, and Ig3 domains. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.
Structure:1EPF_A, rat neural cell adhesion molecule (NCAM) dimer showing Ig1-Ig2 dimer interface, contacts based on 3.5 A distance. - View structure with Cn3D
Jiyao W et al.(2023). "The conserved domain database in 2023.",