1KB5,1NFD,1KTK,2EYR,1ZGL,1OGA,1BWM,1J8H,2ESV,1MI5,1FYT


Conserved Protein Domain Family
IgV_TCR_beta
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cd05899: IgV_TCR_beta (this model, PSSM-Id:143307 is obsolete and has been replaced by 409480)
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Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) bet a chain
IgV_TCR_beta: immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens; they recognize proteins antigens directly and without antigen processing, and MHC independently of the bound peptide.
Links
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Statistics
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PSSM-Id: 143307
Aligned: 22 rows
Threshold Bit Score: 127.406
Created: 26-Dec-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:IgV heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NFD_B; human alpha/beta T-cell receptor (TCR) beta chain IgV domain forms interface with alpha chain IgV domain, contacts based on 3.5 A distance.
    - View structure with Cn3D
  • Comment:Human alpha/beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        # #        #  #                              
1KB5_B      4 LEQnp--rwRLVPRGQAVNLRCILKns-qYPWMSWYQQdlq-kqLQWLFTLRSpgdkevk--slpgadYLATRVtd-tEL 76  house mouse
1NFD_B      4 VVQsp--rhIIKEKGGRSVLTCIPIs--gHSNVVWYQQtlg-keLKFLIQHYEkverdk---gflpsrFSVQQFdd-yHS 74  Mus musculus
1KTK_E      4 VSQhp--srVIAKSGTSVKIECRSLdf-qATTMFWYRQfpk-qsLMLMATSAEgskatye-qgvekdkFLINHAsl-tLS 77  human
BAE16848   25 VSQkpsftiLRTGEFVVSEINCSHSis-sYDRIYWYKQdes-raLKLLGYLNTniqnvee-dvkgkisFDGDGRs---GS 98  torafugu
CAM32532   24 VTQtp---lLWMMEGQSATMNCSHTkgtsYYEMYWYRQlpgqrmKEIVFTTQSpphqyes--gfstekFPATKKda-lTG 97  gilthead seabream
P01735     23 ITQsp---rYLILGRANKSLECEQHl--gHNAMYWYKQsae-kpPELMFLYNLkqlirn---etvpsrFIPECPds-sKL 92  house mouse
BAB82605   24 ITQwp--hyISRFPSGSAEMHCYQNdt-dYNHMYWYRQqrg-kePQLVVYLVGssanfe---egfksgFEAEIVqk-kKW 95  bastard halibut
CAD57366   26 VKQppv-lsVCREGDASVTLRCYHDds-sYYYMFWYRQrd--nnMEMLTYSLGqglweiqppfekdvhYTMSRPel-tRS 100 rainbow trout
AAG46038   20 VIQhp--diSWSFVSQQAEMNCSHKkdvgHNQMYWYRQrpg-etMSLIVYTAVglppdyg--gvsqtkYTASKEky-dYG 93  bicolor damselfish
AAC03369   17 ITQep--rsIITRAGSAALMRCEQKts-dYEWMFWYQQrdg-hgLQLISTQLRgdkptye--egykdgFQVNRTengkIS 90  African clawed frog

Feature 1                   # #                ###      
1KB5_B     77 RLQVAnms--qgRTLYCTCSAApdwgasaeTLYFGSGTRLTV 116 house mouse
1NFD_B     75 EMNMSaleledsAMYFCASSLRwg-----dEQYFGPGTRLTV 111 Mus musculus
1KTK_E     78 TLTVTsahpedsSFYICSALAGsgs--stdTQYFGPGTRLTV 117 human
BAE16848   99 SLSIAavglkdsGVYFCAASPKpt----ggEAYFGSGTKLTV 136 torafugu
CAM32532   98 SLTVErlllndsGVYFCAVTSGgn-----tEAHFGGGTKLTV 134 gilthead seabream
P01735     93 LLHISavdpedsAVYFCASSHGqgv--sgnTLYFGEGSRLIV 132 house mouse
BAB82605   96 SLKIPsiqekdeAVYLCAASRDsn----ydPAYFGSGTKLTV 133 bastard halibut
CAD57366  101 TLEIKnlevgdgAVYYCASSRQgs----nqPAFFGNGTKLSV 138 rainbow trout
AAG46038   94 ALTVKdlqpedsGVYFCAVSTGgd----ydPAYFGKGTKLTV 131 bicolor damselfish
AAC03369   91 FLEIKspkpqdqSLYLCAASDPrg----adRLYFGDGTILTV 128 African clawed frog

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