3ELB,3HL4


Conserved Protein Domain Family
CCT
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cd02174: CCT 
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CTP:phosphocholine cytidylyltransferase
CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the condensation of CTP and phosphocholine to form CDP-choline as the rate-limiting and regulatory step in the CDP-choline pathway. CCT is unique in that its enzymatic activity is regulated by the extent of its association with membrane structures. A current model posts that the elastic stress of the bilayer curvature is sensed by CCT and this governs the degree of membrane association, thus providing a mechanism for both positive and negative regulation of activity.
Links
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Statistics
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PSSM-Id: 173925
Aligned: 35 rows
Threshold Bit Score: 208.19
Created: 19-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site(T/H)XGH motif
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3HL4; rat CTP: phosphocholine cytidylyltransferase with bound CDP-choline, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ####   # ##  #                 #        #                           ##   
3ELB_A      6 RAVRVWCDGCYDXVHYGHSNQLRQARAXg--dYLIVGVHTDEEIAKHKGPPVFTQEERYKXVQAIKWVDEVVPAAPYVTT 83  human
3HL4_A     75 RPVRVYADGIFDLFHSGHARALMQAKNLfpntYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLT 154 Norway rat
P13259    102 RPIRIYADGVFDLFHLGHMKQLEQCKKAfpnvTLIVGVPSDKITHKLKGLTVLTDKQRCETLTHCRWVDEVVPNAPWCVT 181 baker's yeast
P49583     79 RPVRIYADGIYDLFHHGHANQLRQVKKMfpnvYLIVGVCGDRDTHKYKGRTVTSEEERYDGVRHCRYVDEVYREAPWFCT 158 nematode
CAB45996   19 RPVRVYADGIFDLFHFGHARAIEQAKKSfpntYLLVGCCNDEITNKFKGKTVMTESERYESLRHCKWVDEVIPDAPWVLT 98  thale cress
XP_635846 140 RLVRVYADGIYDLFHFGHARSLQQAKSLfkntYLIVGVCNDEITHKLKGKTVMNGEERAESLRHCRWVDEVVENAPWVVT 219 Dictyostelium disc...
NP_586276  41 RPVRIYCDGVYDLFHYGHARSLKQAKNLfpnvYLLVGVTDDDITVRLKGNLVMDENERAEGLIHCRYVDEVITSAPWELT 120 Encephalitozoon cu...
P49587     90 KNVVIYADGVYDMLHLGHMKQLEQAKKLfentTLIVGVTSDNETKLFKGQVVQTLEERTETLKHIRWVDEIISPCPWVVT 169 Plasmodium falcipa...
EAK89672   66 RKIRIYADGVYDLLHLGHMRQLEQAKKMypntHLIVGVASDEETHRLKGRTVQTLQERTETLRHVKWVDEIISPCPWVID 145 Cryptosporidium pa...
EAN33111    8 RVYRIYSDGVFDMLHLGQMRHLEQAKKMfknvYLIAGVTEDDETVRYKSHIVNTMVERAEMLRHIKWVDEVIAPCPWIIT 87  Theileria parva

Feature 1                  ##                                     #            ###  #         
3ELB_A     84 LETLDKYncDFCVHGNDIt-------------------------lTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRX 138 human
3HL4_A    155 PEFLAEHriDFVAHDDIPy-------------------------sSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRI 209 Norway rat
P13259    182 PEFLLEHkiDYVAHDDIPy-------------------------vSADSDDIYKPIKEMGKFLTTQRTNGVSTSDIITKI 236 baker's yeast
P49583    159 VEFLKNLkvDFIAHDAIPy-------------------------vAPGEEDLYEKFRREGMFLETERTEGVSTSDVVCRI 213 nematode
CAB45996   99 TEFLDKHkiDYVAHDALPya-----------------------dtSGAGNDVYEFVKSIGKFKETKRTEGISTSDIIMRI 155 thale cress
XP_635846 220 QEFIDQHniDYVSHGEDLc-------------------------lDKDGNDIYQFVKDQGKFRTIKRTDGISTSDIILRI 274 Dictyostelium disc...
NP_586276 121 LEFLQKHkiDFVAHDDIPy-------------------------kGEDKDDIYKFVKDMGMFIPIRRTKGISTSGIITSI 175 Encephalitozoon cu...
P49587    170 PEFLEKYkiDYVAHDDIPyannqkkkkk-------kkskgksfsfDEENEDIYAWLKRAGKFKATQRTEGVSTTDLIVRI 242 Plasmodium falcipa...
EAK89672  146 EKFVEKHkiDFVAHDDVPyvakqkkrdeedssntdcnsseekpviSYDQDDIYGWLKRCGKFKATQRTKGVSTTDLVVRI 225 Cryptosporidium pa...
EAN33111   88 PDFFHKNklDFVAHDDIPysavqk----------------vsenkTKHCEDIYKWLKDEGKFKATYRTEGISTTECIIKI 151 Theileria parva

Feature 1                    
3ELB_A    139 LLVTKAHHSSQEXSS 153 human
3HL4_A    210 VRDYDVYARRNLQRG 224 Norway rat
P13259    237 IRDYDKYLMRNFARG 251 baker's yeast
P49583    214 IRDYDKYVRRNLQRG 228 nematode
CAB45996  156 VKDYNQYVLRNPGPR 170 thale cress
XP_635846 275 VKDYDSYVMRNLSRG 289 Dictyostelium discoideum AX4
NP_586276 176 VKNYDMYVRRNLERG 190 Encephalitozoon cuniculi GB-M1
P49587    243 LKNYEDYIERSLQRG 257 Plasmodium falciparum (isolate K1 / Thailand)
EAK89672  226 LQNYEEYIDRSLQRG 240 Cryptosporidium parvum Iowa II
EAN33111  152 LQNYEDFIDKFLKNG 166 Theileria parva

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