1LFD,1EF5,1RAX,1RLF


Conserved Protein Domain Family
RalGDS_RA
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cd00153: RalGDS_RA (this model, PSSM-Id:176351 is obsolete and has been replaced by 340449)
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Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
This CD represents the C-terminal Ras-associating (RA) domain of three closely related guanine-nucleotide exchange factors (GEF's), Ral guanine nucleotide dissociation stimulator (RalGDS), RalGDS-like (RGL), and RalGDS-like factor (RLF). The RalGDS proteins are downstream effectors of the Ras-related protein Ral, providing a mechanism for Ral activation by extracellular signals. The RA domain is structurally similar to ubiquitin and exists in a number of other signalling proteins including AF6, rasfadin, SNX27, CYR1, and STE50.
Links
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Statistics
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PSSM-Id: 176351
Aligned: 11 rows
Threshold Bit Score: 134.469
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Ras interaction
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:Ras interaction site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        # #               ## ##   ##       #  ## # #                                 
1LFD_C      2 DCCIIRVSLDVDN-----GNMYKSILVTSQDKAPTVIRKAMDKHNLDedepeDYELLQIIseDHKLKIPENANVFYAMns 76  Norway rat
1EF5_A     17 DTCIIRISVEDNN-----GNMYKSIMLTSQDKTPAVIQRAMSKHNLEsdpaeEYELVQVIseDKELVIPDSANVFYAMns 91  house mouse
1RAX_A     27 DCCIIRVSLDVDN-----GNMYKSILVTSQDKAPAVIRKAMDKHNLEeeepeDYELLQILsdDRKLKIPENANVFYAMns 101 human
1RLF        4 DCRIIRVQMELGEd----GSVYKSILVTSQDKAPSVISRVLKKNNRDsavasEFELVQLLpgDRELTIPHSANVFYAMdg 79  house mouse
AAH05037  515 DCRIIRVQMELGEd----GSVYKSILVTSQDKAPSVISRVLKKNNRDsavasEYELVQLLpgERELTIPASANVFYAMdg 590 human
AAK91126  612 EARVIRVSINNNH-----GNLYRSILLTCQDKAPSVVQRALEKHNVPqpwarDYQLFQVLpgDRELLIPDGANVFYAMsp 686 house mouse
NP_788503 678 DFYIIRVTYETDNieldgIVLYKSIMLGNNERTPQVIRNAMLKLGLEdd-pdRFTLAQVLp-DKELVMPKNANVYYAVnt 755 fruit fly
CAE68393  737 SFYLARVGLDDDLqn-tdGANYKCIKIENGDRMPQLIARALEKHLIDde-knKYLLVQLLprGGEFVLPDNCNPFYAMap 814 Caenorhabditis bri...
NP_991200 684 DACIIRVSLEQGN-----GNLYKSIMLTSQDKTPAVISRAMTKHNLEgeqaaDYELVQVIseERELVIPDNANVFYAMst 758 zebrafish
CAG32313  648 DTCIIRISVEDNN-----GNMYKSIMLTSQDKTPAVIQRAMSKHNLEsdaaeEYELVQVIseDKELVIPDSANVFYAMns 722 chicken
XP_393803 684 DFYIIKVTMESDNvetegVVLYKSIMLSNNERTPQVIRNAMLKLGIEgs-pdQYTLAQVLp-DREMLLPNSANVYYAVnt 761 honey bee

Feature 1                   
1LFD_C     77 a---anYDFILKKR 87  Norway rat
1EF5_A     92 q---vnFDFILRKK 102 house mouse
1RAX_A    102 t---anYDFVLKKR 112 human
1RLF       80 ----asHDFLLRQR 89  house mouse
AAH05037  591 ----asHDFLLRQR 600 human
AAK91126  687 a---apGDFLLRRK 697 house mouse
NP_788503 756 n---ynLNFILRPR 766 fruit fly
CAE68393  815 dptspmLNLMLRKR 828 Caenorhabditis briggsae
NP_991200 759 s---anFDFLLRLR 769 zebrafish
CAG32313  723 q---vnFDFILRKK 733 chicken
XP_393803 762 a---hnLNFILRPR 772 honey bee

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