1C1Y


Conserved Protein Domain Family
Raf_RBD
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cd01816: Raf_RBD (this model, PSSM-Id:176411 is obsolete and has been replaced by 340514)
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Ubiquitin domain of Raf serine/threonine kinases
The Raf serine/threonine kinases are composed of three conserved regions, CR1, CR2 and CR3. CR1 has two Ras binding domains (RBD and CRD), CR2 is a serine/threonine rich domain and CR3 is the catalytic kinase domain. The RBD of Raf is structurally similar to ubiquitin with little of no sequence similarity.The Raf signalling pathway plays an important role in the proliferation and survival of tumor cells.
Links
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Statistics
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PSSM-Id: 176411
Aligned: 16 rows
Threshold Bit Score: 114.804
Created: 8-May-2010
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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RafRBD - Ras
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:RafRBD - Ras interaction site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       #    # #### #            #   ###                                         
1C1Y_B      3 TIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLhehkgkkarLDWNTDAASLIGEELQVDFL 77  human
P05625     57 TIRVFLPNKQRTVVNVRNGMTLHDCLMKALKVRGLQPECCAVFRLVtepkgkkvrLDWNTDAASLIGEELQVDFL 131 chicken
AAB20707   57 TMRVYLPNKQRTVVNVRSGMSLHDCLMKSLKVRGLQPECCAVFRLIqdpk-gklrLDWNTDAMSLVGAELQVDFL 130 African clawed frog
P11346    184 LLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHsgr----hiIPWHTDIGTLHVEEIFVRLL 254 fruit fly
Q04982    156 IVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQdge---kkpIGWDTDISWLTGEELHVEVL 227 chicken
O19004     20 TVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIkgr---ktvTAWDTAIAPLDGEELIVEVL 91  pig
NP_002871  57 TIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLhehkgkkarLDWNTDAASLIGEELQVDFL 131 human
XP_318144 117 LLRAFLPNQQRTSVQVIPGMRLKDALAKALKRRNLTCEFCEVTAGNsn-----ypIPWETDVSALNCDEVFVRIL 186 Anopheles gambiae str. ...
BAD01470  137 IVRVFLPNKQRTVVPARSGVTVRDSLKKALMMRGLIPECCAVYRVQdge---kkpIGWDTDISWITGEELHVEVL 208 African clawed frog
BAD16727  166 IVRVFLPNKQRTVVPARCGMTVRDSLKKALMMRGLIPECCAVYRVQdge---kkpIGWDTDISWLTGEELHVEVL 237 zebrafish

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