1DHP,1JCJ,1OJX,1EUA,1F05,4ALD,1FDZ,1L6W,1QFE,1MZH,1N7K,1O0Y,1J2W


Conserved Protein Domain Family
Aldolase_Class_I

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cd00945: Aldolase_Class_I 
Click on image for an interactive view with Cn3D
Class I aldolases
Class I aldolases. The class I aldolases use an active-site lysine which stabilizes a reaction intermediates via Schiff base formation, and have TIM beta/alpha barrel fold. The members of this family include 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-4-hydroxyglutarate (KHG) aldolases, transaldolase, dihydrodipicolinate synthase sub-family, Type I 3-dehydroquinate dehydratase, DeoC and DhnA proteins, and metal-independent fructose-1,6-bisphosphate aldolase. Although structurally similar, the class II aldolases use a different mechanism and are believed to have an independent evolutionary origin.
Statistics
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PSSM-Id: 188634
View PSSM: cd00945
Aligned: 117 rows
Threshold Bit Score: 32.6853
Threshold Setting Gi: 9955241
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:the catalytic lysine forms Schiff-base intermediate with the substrates.
  • Comment:a characteristic of class I aldolases
  • Structure:1EUA: pyruvate bound
    View structure with Cn3D
  • Structure:1L6W; circular permutation in transaldolase
    View structure with Cn3D
  • Citation:PMID 8805555

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1DHP_A      5 SIVAIvtpmdek--------gnvcrasLKKLIDYhvasgtSAIVSVgttgesatlnhdehadVVMMTLDLadg--ripVI 74  Escherichia coli
1EUA_A     17 VVPVIvvkk---------------lehAVPMAKAlvaggvRVLEVTlrte--------cavdAIRAIAKEvpe---aiVG 70  Escherichia coli
NP_874790  17 IHQAAldphi-------------nldsLNQICDVckhfnfAGLCTNl--------------iRIQAARKSlgknkqtkLI 69  Prochlorococcus ma...
NP_896759  15 LDQAVldpll-------------tveqLNERCDAgrqervRAICTSl--------------rQLPLLRERlggqggpkLI 67  Synechococcus sp. ...
NP_894045  17 INQALldphl-------------dqdvLQQTCDAarhfgfAGVCTNl--------------nRLQAARERlgppgptrLI 69  Prochlorococcus ma...
P71295     69 SILPVdqgvehsaga--sfaanplyfdPKNIVELaieagcNCVASTy--------------gVLASVSRRyah--ripFL 130 Escherichia coli O6
NP_487775  75 SILPVdqgiehsaga--sfapnpiyfdPENIIRLaiaggcNAVATTl--------------gVLGSVSRKyah--kipFI 136 Nostoc sp. PCC 7120
NP_810572  69 SILPVdqdiehtaga--sfapnpiyfdPENIVKLaieggcNAVASTf--------------gILGSVARKyah--kipFV 130 Bacteroides thetai...
NP_866279  86 SILPVdqgiehsaga--sfapnldyfdPENIVKLaieggcNAVASTf--------------gVLGAVSRKyah--ripFL 147 Pirellula sp. 1
Q58980     43 MLFAGdqkiehlnddffgegiakddasPEHLFNIaskgkiCGFATQl--------------gLIARYGMDykk---ipYI 105 Methanocaldococcus...
Feature 1                                                                                     
1DHP_A     75 AGTgana--------taeaISLTQRFnds----givGCLTVTpyynrps--qeglyqhFKAIAeh---tdLPQILYNvps 137 Escherichia coli
1EUA_A     71 AGTvl-------------nPQQLAEVtea----gaqFAISPGlt------------epLLKAAte---gtIPLIPGIs-- 116 Escherichia coli
NP_874790  70 AVIafpfgd----ipnsikKTEAELAaeh----gaeELDIVPnylklyegkidsfaeeLAEIFki----gLPYRVILdsi 137 Prochlorococcus ma...
NP_896759  68 AAIgfpfga----lpaelrLAEATWAaah----gadELDVVPdfsalvegdssgfaedLAAITgl----gLPVRVVLdma 135 Synechococcus sp. ...
NP_894045  70 AVIafpfga----ipstlkQAEAEWAadh----gaeELDVVPdfwtlsqgraelfaeeLAEICal----gLPVHVILnma 137 Prochlorococcus ma...
P71295    131 VKLnhnetlsypntydqtlYASVEQAfnm----gavAVGATIyfgsees---rrqieeISAAFerahelgMVTVLWAylr 203 Escherichia coli O6
NP_487775 137 AKLnhnelltfpnqfdqvlFADVEQAwnl----gavAVGATIyfgseqs---trqiqeISRAFkrahelgMVTILWCylr 209 Nostoc sp. PCC 7120
NP_810572 131 VKLnhnelltypntydqvlFGTVKEAwnm----gavAVGATIyfgseqs---rrqlveIAEAFeyahelgMATILWCylr 203 Bacteroides thetai...
NP_866279 148 VKInhnellsypntydqvmFGQVDRAhdm----gatAVGATIyfgspes---rrqiveVAESFerahelgLATVLWCylr 220 Pirellula sp. 1
Q58980    106 VKInskthlvktrdpisraLVHVKDVvdlkensglkILGVGYtiypgsey-ehimfeeASRVIleahkhgLIAIIWSypr 184 Methanocaldococcus...
Feature 1                                       #                                             
1DHP_A    138 rt-----------gcdlLPETVGRlakvkniIGIKEAtg-----nLTRVNQIKelvs----------------------- 178 Escherichia coli
1EUA_A    117 -----------------TVSELMLgmd-yglKEFKFFpaea-nggVKALQAIAgpfs----------------------- 154 Escherichia coli
NP_874790 138 ri-----------peekLSLAIEAsid-agaRGIQAGngf---gtPIQASHILklrali--------------------- 181 Prochlorococcus ma...
NP_896759 136 rl-----------pedlLAIAVEAsid-adaAGVQSGngfgppcqAEQVAALSglcr----------------------- 180 Synechococcus sp. ...
NP_894045 138 rl-----------padrLNLAVDAaid-advSGLQSGngfgpavtAADIRLLTnlar----------------------- 182 Prochlorococcus ma...
P71295    204 nsafkkdgvdyhvsadlTGQANHLaat-igaDIVKQKma----enNGGYKAINygytddrvyskltsenp------idlv 272 Escherichia coli O6
NP_487775 210 nnafkqd-kdyhlaadlTGQANHLgvt-ieaDIIKQKlp----enNNGYGAVAkatgqsygkthekvytdlttdhpidlt 283 Nostoc sp. PCC 7120
NP_810572 204 nsdfkkgaidyhaaadlTGQADRLgvt-ikaDIVKQKlp----tnNGGFKAIGfgktdermyteltsehp------idlc 272 Bacteroides thetai...
NP_866279 221 npafktd-qdyhtsadlTGQANHLgvt-iqaDIIKQKlp----tnNGGYNAIAfgktsplv------------------- 275 Pirellula sp. 1
Q58980    185 gknvk-----dekdphlIAGAAGVaac-lgaDFVKVNypkc-dnpAERFKEAVlaag----------------------- 234 Methanocaldococcus...
Feature 1                                                                        
1DHP_A    179 ---------ddfvLLSGDd------------------------------aSALDfmql-gghGVISV 205 Escherichia coli
1EUA_A    155 ----------qvrFCPTGgis---------------------------paNYRDylalksvlCIGGS 184 Escherichia coli
NP_874790 182 --------knrceLKVAGgik--------------------------nlhQVLElvea-gasSIGTS 213 Prochlorococcus marinus subsp. ...
NP_896759 181 ---------grcaIKAAGgih--------------------------hpkLAMDllea-gaaLVGTS 211 Synechococcus sp. WH 8102
NP_894045 183 ---------grcgIKAAGglh--------------------------tldQALDmvea-gatRLGTS 213 Prochlorococcus marinus str. MI...
P71295    273 ryqlancymgragLINSGgaagget------------------dlsdavrTAVInkra-ggmGLILG 320 Escherichia coli O6
NP_487775 284 ryqvlncycgragLINSGgasgknd-------------------faeavrTAVInkra-ggtGLISG 330 Nostoc sp. PCC 7120
NP_810572 273 ryqvangymgrvgLINSGgeshgas------------------dlrdaviTAVVnkra-ggmGLISG 320 Bacteroides thetaiotaomicron VP...
NP_866279 276 -----yqklttdhPIDLCryqvancfmgraglinsggassgasdlaeavkTAVInkra-ggtGLISG 336 Pirellula sp. 1
Q58980    235 ----------rtgVLCAGgksiep---------------------ekflkQIWEqinisgarGNATG 270 Methanocaldococcus jannaschii

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