1JCJ,1J2W,1MZH,1N7K,1O0Y


Conserved Protein Domain Family
DeoC

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cd00959: DeoC 
Click on image for an interactive view with Cn3D
2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family
2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.
Statistics
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PSSM-Id: 188646
View PSSM: cd00959
Aligned: 72 rows
Threshold Bit Score: 187.353
Threshold Setting Gi: 33860956
Created: 11-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1JCJ_A       12 ALKLMDLTTLNDDDTDEKVIALCHQAKtpvgNTAAICIYPRFIPIARKTlkeqgtpeiRIATVTNFPHGnddiDIALAET 91  Escherichia coli
NP_407077    10 VAKAIQFTNVNADLTREGVIKHLNICLe--yQFDAAMIAPCWVYLAKDVlkg---sgvRVATTVNFPQAndttAMKVAIV 84  Yersinia pestis ...
Q8YPM0       10 IAPFIDHALLTPTATPEQVDQWCEQADr--yNFASVCLYPTYVKQAAEFlhg---kkpKVCTVIGFPTGattrSVKLYEA 84  Nostoc sp. PCC 7120
Q97CC6        8 VMSLVDHSGLKPYLREDEIARLIGEASe--mGNYSVCIEPIYGNFAVEYikek-gyslKVDVTLDFPFGs--lPTSARKK 82  Thermoplasma vol...
NP_874790    13 INSFIHQAALDPHINLDSLNQICDVCKh--fNFAGLCTNLIRIQAARKSlgkn--kqtKLIAVIAFPFGdipnSIKKTEA 88  Prochlorococcus ...
NP_894045    13 LAPLINQALLDPHLDQDVLQQTCDAARh--fGFAGVCTNLNRLQAARERlgpp--gptRLIAVIAFPFGaipsTLKQAEA 88  Prochlorococcus ...
NP_896759    11 LPSCLDQAVLDPLLTVEQLNERCDAGRq--eRVRAICTSLRQLPLLRERlggq--ggpKLIAAIGFPFGalpaELRLAEA 86  Synechococcus sp...
ZP_00164124  10 LAPYIEHSLLDPAATLEQIDQLCQEADr--yHFAAVCLFPWVVRQAREWlng---rspRLCTVIDFPNGastaASKVYAA 84  Synechococcus el...
Q7NFI7       10 LAGFIEQTCLKPTATADDVRQMCWEAQr--yRFAAVCVAPVYAPLAVELlhk---qkpQVFTVVGFPLGlataPCKLFEA 84  Gloeobacter viol...
ZP_00327894  10 IAPFIDHSLLTITATPEEVSKFCIEADk--fRFPSVCVYPCHVRKVVDLlst---kspKVSTVINFPNGtatsKTKLYEA 84  Trichodesmium er...
Feature 1                                                                                   #  #
1JCJ_A       92 RAAIAYGADEVDVVFPYRAlmagneqVGFDLVKACKEACaaanVLLKVIIETGELkdEALIRKASEISIKAGADFIKTST 171 Escherichia coli
NP_407077    85 RELAKEGADEFDFPPNPGFllggldeLYFNELKEVTHIAhdlgMKVKAMLEFGFIteEAMKIKATRYAYEAGIDWVKQSS 164 Yersinia pestis ...
Q8YPM0       85 LEAVENGATELDVVINLGClksgnteAVHREIAEICEETg---QVVKVILETNLLt-DAEKKIAADIAMDAGATFLKTNT 160 Nostoc sp. PCC 7120
Q97CC6       83 IIEDSVYADEIDMVIPIGYvkshrwdKVEQDINDVVSTArdlgLVSKIITEDGYLt-LDEKLKTYDIVIRSAPDFIKTST 161 Thermoplasma vol...
NP_874790    89 ELAAEHGAEELDIVPNYLKlyegkidSFAEELAEIFKIG----LPYRVILDSIRIp-EEKLSLAIEASIDAGARGIQAGN 163 Prochlorococcus ...
NP_894045    89 EWAADHGAEELDVVPDFWTlsqgraeLFAEELAEICALG----LPVHVILNMARLp-ADRLNLAVDAAIDADVSGLQSGN 163 Prochlorococcus ...
NP_896759    87 TWAAAHGADELDVVPDFSAlvegdssGFAEDLAAITGLG----LPVRVVLDMARLp-EDLLAIAVEASIDADAAGVQSGN 161 Synechococcus sp...
ZP_00164124  85 QEAVENGAQELNVVVNLGWlrsdradLVHQELAEIVEATg---VPIKAILEATRLn-PSELEQLTDLCLDAGVTMLQTST 160 Synechococcus el...
Q7NFI7       85 QEAAARGVTGLEVMVNLGAiksghynAIYEELGQIVDAVg---CEVRAILELNLLd-ATERRHVAEVCLDVGVTALKTSA 160 Gloeobacter viol...
ZP_00327894  85 LEAVENGASELDVMVNLTYiktgemsQLHREIAEIREETg---KTVKAILEMALLt-KDEKYLVIEVLMDAGVAFIATNT 160 Trichodesmium er...
Feature 1                                                 ###                              ###
1JCJ_A      172 Gkva----------vnATPESARIMMEvirdmgvektvGFLPAGGVRTAEDAQKYLaiadelfgadwadarhYRFGAS 239 Escherichia coli
NP_407077   165 Gwgkg--------gcaATVEDVQLLKAniq-----apcRVKVSGKVNTLEKMKEMFla------------gaELVGTS 217 Yersinia pestis CO92
Q8YPM0      161 Gwn-----------ggATVADVKLLKDitr-----ervGIKASGGIRTLNQALDLIla------------gaTRLGTS 210 Nostoc sp. PCC 7120
Q97CC6      162 GfadkefckslgnetgATPENVKLMSEiakki--gsniGIKAAGGIHTYDQVEKIIdsagmi-----pepsnIRLGMS 232 Thermoplasma volca...
NP_874790   164 Gf--------------GTPIQASHILKlrali--knrcELKVAGGIKNLHQVLELVea------------gaSSIGTS 213 Prochlorococcus ma...
NP_894045   164 Gfg-----------paVTAADIRLLTNlar-----grcGIKAAGGLHTLDQALDMVea------------gaTRLGTS 213 Prochlorococcus ma...
NP_896759   162 Gfg-----------ppCQAEQVAALSGlcr-----grcAIKAAGGIHHPKLAMDLLea------------gaALVGTS 211 Synechococcus sp. ...
ZP_00164124 161 Gwf-----------ggATPALVQQLRQltr-----nrvGIHAAGGIRTWDQAAALVea------------gaIRLGTS 210 Synechococcus elon...
Q7NFI7      161 Gws-----------gpVRPEDILGLRRilr-----nqlGIKVAGGIHTLNQALELLaa------------gaNRLGTG 210 Gloeobacter violaceus
ZP_00327894 161 Gwy-----------ggATVADVKLLKEitk-----anvGIKAAGGIKTYEQAVSLVla------------gaTRLGTS 210 Trichodesmium eryt...

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