Conserved Protein Domain Family
LIM2_Enigma

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cd09456: LIM2_Enigma 
The second LIM domain of Enigma
The second LIM domain of Enigma: Enigma was initially characterized in humans as a protein containing three LIM domains at the C-terminus and a PDZ domain at N-terminus. The third LIM domain specifically interacts with the insulin receptor and the second LIM domain interacts with the receptor tyrosine kinase Ret and the adaptor protein APS. Thus Enigma is implicated in signal transduction processes, such as mitogenic activity, insulin related actin organization, and glucose metabolism. Enigma is expressed in multiple tissues, such as skeletal muscle, heart, bone and brain. LIM domains are 50-60 amino acids in size and share two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes.
Statistics
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PSSM-Id: 188840
Aligned: 5 rows
Threshold Bit Score: 116.635
Created: 28-Jul-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #  #                #  #  #  #                 #  # 
NP_005442 341 CAKCKKKItGEIMHALKMTWHVHCFTCAACKTPIRNraFYMEEGVPYCERDY 392 human
Q679P3    300 CAKCKKKItGEVMHALKMTWHVQCFTCAACKTPIRNraFYMEEGQPYCERDY 351 chicken
Q6P7E4    303 CAKCKKIItGEIMHALKMTYHVQCFLCAACKLPIRNqaFYMEEGEPYCERDY 354 zebrafish
Q6INU3    305 CAKCKKKItGEIMHALKMTWHVPCFTCAYCKTPIRNraFYMEDGKPYCEKDY 356 African clawed frog
XP_853979 379 GTKCQERViGHIMHALKMTWHVHCFTCAACKTPIRNraFYMEEGAPYCERDY 430 dog

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