2E8M,1WWU


Conserved Protein Domain Family
SAM_EPS8-like

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cd09540: SAM_EPS8-like 
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SAM domain of EPS8-like subfamily
SAM (sterile alpha motif) domain of EPS8-like subfamily is a putative protein-protein interaction domain. This subfamily includes epidermal growth factor receptor kinase substrate 8 proteins (EPS8) and epidermal growth factor receptor kinase substrate 8-like (EPSL8) 1, 2, 3 proteins with the SAM domain located in the C-terminal effector region. This region is responsible for intracellular protein localization and is involved in small GTPases (such as Rac and Rab5) activation/inhibition. Proteins belonging to this group participate in coordination and integration of multiple signaling pathways; in particular, they play a role in the control of actin dynamics and in receptor endocytosis. They can form complexes with other proteins; for example, in the actin signaling network they interact with SOS1 and E3b1 (Abl1) proteins as well as with CRIB (via SH3 domains) during the actin filament formation, and in the receptor endocytosis their partner is RN-tre protein.
Statistics
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PSSM-Id: 188939
Aligned: 16 rows
Threshold Bit Score: 108.184
Created: 27-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2E8M_A        29 NITYDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCP-EGARVYSQITVQKAAL 93   human
XP_002938326 630 PLTDESSPAEVTAWLQAKGFNTLTVNSLGVLNGVQLFSLRKDEFRAVCPeEGARVYSQVMVQKALL 695  western clawed frog
Q8TE68       629 QLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPeEGARVYSQVTVQRSLL 694  human
XP_001190240 904 TLTYDSSRDDVKRWLESKGFSPMTVHSLGILNGAQLFSLTKEELQQVCHdDGSRVYSQLMIQKAAL 969  Strongylocentrotus purpuratus
NP_001015709 432 VLNPSSRPEEVKAWLQQKGFSNITVRCLGVLQGDQLLELTREDLKTVCPeEGGRVYLQLSTVRGSL 497  western clawed frog
XP_002121734 626 VLTKDSSQAEVKTWLLSHGFSSLTIDSLSVLNGAQIFSLTKDELKMICDdEGSRVHSQLLVQKSMP 691  Ciona intestinalis
XP_002666161 571 ALNRKSRPEEVRAWLEHKGFSKITVRCLGGVSGSMLLGMTRDELKTICPeEGGRVFYQLQNIKSAL 636  zebrafish
NP_001072508 686 HISYSSPAEDVKSWLQAKGFNSVTVDSLGVLTGAQLFSLTKDELKTVCP-EGPRVYNQVTVQKAAI 750  western clawed frog
NP_956536    701 SISYDSTPQQVKDWLMLKGFSAATVSSLGVLTGAQLFSLNKDELKTVCPdDGARVFSQISVQKAAL 766  zebrafish
NP_001013331 428 PLDYHSPQAEVQEWLKAKGFNNITVQSLGVLNGAQLFSLNKEELRAVCPeEGARVYSQITVQKSLL 493  zebrafish
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