Conserved Protein Domain Family
Toxin_8

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pfam07365: Toxin_8 
Alpha conotoxin precursor
This family consists of several alpha conotoxin precursor proteins from a number of Conus species. The alpha-conotoxins are small peptide neurotoxins from the venom of fish-hunting cone snails which block nicotinic acetylcholine receptors (nAChRs).
Statistics
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PSSM-Id: 191732
Aligned: 22 rows
Threshold Bit Score: 50.8761
Threshold Setting Gi: 239977092
Created: 20-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P0C1X1 17 TTVVSIPSDRASDGRNAVVHERAPELvvtaTT-NCCGYnpmticPPCMCTyS--C-P 69  magus cone
P0C828 17 TTVVSTPSDRASDGRNAAVHERQKSLvpsvIT-TCCGYdpgtmcPPCRCTnS--C-G 69  striated cone
A1X8C2 17 TTVVSFNSDRESNHENR----RTSNQitrgVWdECCKD------PQCRQNhMqhCpA 63  Conus leopardus
P0CAQ5 17 TTVVSFPSDSASDGRDDEAKDERSDMykskRNgRCCH-------PACGKHfS--C-G 63  Conus achatinus
P0C1W4 17 ITVVSFPLDRESDGANAEARTHDHEKha-ldRnGCCRN------PACESHr---C-G 62  striated cone
P56636 17 TTVVSFPSDRASDGRNAAANDKASDVitlaLK-GCCSN------PVCHLEhSnlC-G 65  magus cone
Q6PTD3 17 TTVVSFTSDRASDGRNAEA--KALDLiaatARpRCCSN------PACGAGhPeiCaG 65  Conus leopardus
A6M934 17 TTVVSFTSDRGSDGRNAAAKDKASDLvaltVK-GCCSN------PPCYANnQayCnG 66  Conus marmoreus
P50985 17 TTVVSFTSDRASDDGNAAA----SDLialtIK-GCCSL------PPCALSnPdyC-G 61  Conus pennaceus
O77256 17 TTVVPITLASATDGRNAAANARVSPVisksSKkWCHPN------PYTV--------G 59  Conus imperialis
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