2EZS


Conserved Protein Domain Family
HIV-1-like_HR1-HR2

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cd09909: HIV-1-like_HR1-HR2 
Click on image for an interactive view with Cn3D
heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains
This domain family spans both heptad repeats of the glycoprotein (gp)/transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including human, simian, and feline immunodeficiency viruses (HIV, SIV, and FIV), bovine immunodeficiency-like virus (BIV), equine infectious anaemia virus (EIAV), and Jaagsiekte sheep retrovirus (JSRV), mouse mammary tumour virus (MMTV) and various ERVs including sheep enJSRV-26, and human ERVs (HERVs): HERV-K_c1q23.3 and HERV-K_c12q14.1. This domain belongs to a larger superfamily containing the HR1-HR2 domain of ERVs and infectious retroviruses, including Ebola virus, and Rous sarcoma virus. Proteins in this family lack the canonical CSK17-like immunosuppressive sequence, and the intrasubunit disulfide bond-forming CX6C motif found in linker region between HR1 and HR2 in the Ebola_RSV-like_HR1-HR2 family. N-terminal to the HR1-HR2 region is a fusion peptide (FP), and C-terminal is a membrane-spanning region (MSR). Viral infection involves the formation of a trimer-of-hairpins structure (three HR1 helices, buttressed by three HR2 helices lying in antiparallel orientation). In this structure, the FP (inserted in the host cell membrane) and MSR (inserted in the viral membrane) are in close proximity. ERVs are likely to originate from ancient germ-line infections by active retroviruses. Some modern ERVs, those that integrated into the host genome post-speciation, have a currently active exogenous counterpart, such as JSRV. Some ERVs play specific roles in the host, including placental development, protection of the host from infection by related pathogenic and exogenous retroviruses, and genome plasticity. Included in this subgroup are ERVs from domestic sheep that are related to JSRV, the agent of transmissible lung cancer in sheep, for example enJSRV-26 that retains an intact genome. These endogenous JSRVs protect the sheep against JSRV infection and are required for sheep placental development. HERV-K_c12q14.1 is potentially a complete envelope protein; however, it does not appear to be fusogenic.
Statistics
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PSSM-Id: 197369
View PSSM: cd09909
Aligned: 18 rows
Threshold Bit Score: 95.9271
Threshold Setting Gi: 82281565
Created: 17-Nov-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 53 residues -Click on image for an interactive view with Cn3D
Feature 1:HR1
Evidence:
  • Comment: first heptad repeat region (HR1), HR1 and HR2 form antiparallel helices
  • Citation:PMID 9299329

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     ####################  #################################                         
2EZS_A      1 AQSRTLLAGIVQQQQQLLDVvkRQQELLRLTVWGTKNLQTRVTAIEKYLKDQAQLNAW-GAAFRQ--VAHTTV-PWpNAS 76  SIV
O36317    462 NKIMEVQNHTFEVENSTLNGmdLIERQIKILYAMILQTHADVQLLKERQQVEETFNLI-GCIERThvFCHTGH-PW-NMS 538 Equine infectious ...
Q992J3    480 NKLDSVQNHTFEVENNTINSieLTEEQIHILYAMVLQTHADVQLLKEQQKIEETFNLI-GCIERShtFCHTGH-PW-NES 556 Equine infectious ...
Q66975    640 TQYHQVLATHQEAIEKVTEAlkINNLRLVTLEHQVLVIGLKVEAMEKFLYTAFAMQEL-GCNQNQf-FCKIPPgLW-TRY 716 Feline immunodefic...
ABV71071  414 VDSLSYNVTKVMGTQEDIDK--KIEDRLSALYDVVRVLGEQVQSINFRMKIQCHANYKwICVTKKp-YNTSDF-PW-DKV 488 sheep
O42043    390 VNYWQKNSTRLWNSQSSIDQ--KLASQINDLRQTVIWMGDRLMTLEHHFQLQCDWNTSdFCITPQi-YNESEH-HW-DMV 464 human
P61565    500 VNDWQKNSTRLWNSQSSIDQ--KLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSdFCITPQi-YNESEH-HW-DMV 574 human
ABH06977  492 VNNLHRNVTLALSEQRIIDL--KLEARLNALEEVVLELGQDVANLKTRLSTKCHANYDfICVTPL--PYNATE-SW-ERT 565 Mouse mammary tumo...
Q4KWC9    127 VNNLHRNVTLALSEQRIIDL--KLEARLNALEEVVLELGQDVANLKTRMSTRCHANYDfICVTPL--PYNASE-SW-ERT 200 human
Q90RI3    414 VDSLSYNVTKVMGTQEDIDK--KIEDRLSALYDVVRVLGEQVQSINFRMKIQCHANYKwICVTKKp-YNTSDF-PW-DKV 488 Jaagsiekte sheep r...
Feature 1                                                              
2EZS_A     77 LTp-------kWNNETWQEWERKVDFLEENIt---ALLEEAQIQQEKnMYELQKLNS 123 SIV
O36317    539 WGh-------lNESTQWDDRVSKVEDLNQEIl---TILHGARNNLAQsMITFNTPDS 585 Equine infectious anemia virus
Q992J3    557 WGq-------lNDSTQWDDWVDKMENLNHDIl---TTLHTARNNLEQsMITFNTPDS 603 Equine infectious anemia virus
Q66975    717 NMtinq-tiwnHGNITLGEWYNKTKDLQQKFy---EIIMDIEQNNVQgKTGIQQLQK 769 Feline immunodeficiency virus
ABV71071  489 KKhlqgiwfntNVSLDLLQLHNEILDIENSPkatlNIADTVDNFLQNlFSNFPSLHS 545 sheep
O42043    465 RRhlqg--redNLTLDISKLKEQIFEASKAHl---NLVPGTEAIAGV-ADGLANLNP 515 human
P61565    575 RRhlqg--redNLTLDISKLKEQIFEASKAHl---NLVPGTEAIAGV-ADGLANLNP 625 human
ABH06977  566 RAhllgiwndnEISYNIQELTNLISDMSKQHi---DAVDLSGLAQSF-ANGVKALNP 618 Mouse mammary tumor virus
Q4KWC9    201 KAhllgiwndnEISYNIQELTNLISDMSKQHi---DTVDLSGLAQSF-ANGVKALNP 253 human
Q90RI3    489 KKhlqgiwfntNLSLDLLQLHNEILDIENSPkatlNIADTVDNFLQNlFSNFPSLHS 545 Jaagsiekte sheep retrovirus

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