Conserved Protein Domain Family
GS
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smart00467: GS 
GS motif
Aa approx. 30 amino acid motif that precedes the kinase domain in types I and II TGF beta receptors. Mutation of two or more of the serines or threonines in the TTSGSGSG of TGF-beta type I receptor impairs phosphorylation and signaling activity.
Links
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Statistics
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PSSM-Id: 197743
Aligned: 12 rows
Threshold Bit Score: 28.2832
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q24326       226 SPLSQLVEQ--SSGSGS-GLPLLVQRTIAKQI 254 fruit fly
Q23975       273 TTIHDIIEMt-TSGSGSaGLPLLVQRSIARQV 303 fruit fly
O17471       275 TIPADLMDHt-CSGSGS-GKPLLVQRTVARQV 304 Schistosoma mansoni
AAC47801     239 IEKAPMLYDi-SSGSGS-GFASLNQRTVAQDL 268 Brugia pahangi
NP_001023160 265 KDMLDVLEE--TSGSGM-GPTTLHKLTIGGQI 293 nematode
BAA82603     194 DSIPEGMTC--TSGSGS-GLPFLIQRTVARNI 222 Ephydatia fluviatilis
NP_495271    238 MESKSMLED---SGSGS-GQAALIQRTVRQDL 265 nematode
BAA82602     185 PIVEDIAVDtiTSGSGS-GKPYLTKRTFSRRV 215 Ephydatia fluviatilis
XP_003365286 125 KTLQDLVYDlsTSGSGS-GLPLFVQRTVARTI 155 horse
XP_002076219 171 STLREYLQHsvTSGSGS-GLPLLVQRTLAKQV 201 Drosophila simulans
BAA82604     408 EQSSDLAED--SGGSGS-GLPLLSQQSIAAQI 436 Ephydatia fluviatilis
XP_002752530 172 SMLGDLLDSdcTTGSGS-GLPFLVQRTVARQV 202 white-tufted-ear marmoset
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