2BE6


Conserved Protein Domain Family
Ca_chan_IQ
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smart01062: Ca_chan_IQ 
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Voltage gated calcium channel IQ domain
Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
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Statistics
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PSSM-Id: 198130
Aligned: 23 rows
Threshold Bit Score: 45.2905
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2BE6_D          4 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 34   human
XP_001356193 2028 DEVTVGKFYATYLIQDYFRRFKKRKEQEGKE 2058 Drosophila pseudoobscura pseudoobscura
XP_001914915 1863 SDLTVGKIYAAMMIMDYYKQSKAKKQRQQLE 1893 horse
XP_520396    1831 DEMTVGKVYAALMIFDFYKQNKTTRDQMQQA 1861 chimpanzee
XP_698014    1803 TDLTVGKIYAAMMIMEYYRQSKAKKLQALRE 1833 zebrafish
XP_003339736 1844 DEMTVGKVYAALMIFDFYKQNKNTRDQGHQp 1874 gray short-tailed opossum
XP_002665969 1834 NELTVGKVYAALMIFDYYKQNRAKRLQQ-QQ 1863 zebrafish
XP_001920777 1862 SDMTIGKIYAAMMIMDYYKQNKAKKLRQQLE 1892 zebrafish
EGK96852     1487 GKLTVGKIYAGLLILESWRNTKFGQVESDLP 1517 Anopheles gambiae str. PEST
NP_001123176 1623 QKLTVGKIYAGLLILENYRARKSGTEVGGQG 1653 nematode
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