1H8L,3MN8,2NSM,1UWY,1QMU


Conserved Protein Domain Family
Peptidase_M14NE-CP-C_like

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cd11308: Peptidase_M14NE-CP-C_like 
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Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
This domain is found C-terminal to the M14 carboxypeptidase (CP) N/E subfamily containing zinc-binding enzymes that hydrolyze single C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes enzymatically active members (carboxypeptidase N, E, M, D, and Z), as well as non-active members (carboxypeptidase-like protein 1, -2, aortic CP-like protein, and adipocyte enhancer binding protein-1) which lack the critical active site and substrate-binding residues considered necessary for activity. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. For M14 CPs, it has been suggested that this domain may assist in folding of the CP domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; for carboxypeptidase M, it may interact with the bradykinin 1 receptor at the cell surface. This domain may also be found in other peptidase families.
Statistics
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PSSM-Id: 200604
View PSSM: cd11308
Aligned: 74 rows
Threshold Bit Score: 66.3936
Threshold Setting Gi: 124002378
Created: 18-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1H8L_A        302 GIWGFVLDatdGRGILNATISVADin------hPVTTYK-DGDYWRLLVQGTYKVTASARGYDPVT-KTVEVdsk---gg 370  crested duck
ZP_01687231   408 GIRGVVTDa-vTNQPITAKVTVVGkeg---yesWVPTELpEGDYYRPIKAGTYSILVEAACYQSVTiSGVTIgdq---qt 480  Microscilla m...
XP_966816     329 GVKGVVRDg-rGEPVLDADVVVKEva------hNVSTSN-RGEFWRLLLPGKYTMFATAYGFEPSDeVSVTVeeg---kt 397  red flour beetle
O89001       1211 GVHGLVKDk-aGKPISKAVIVLNEg-------iKVYTKE-GGYFHVLLAPGVHNINAIADGYQQQH-TQVFVhhda-ass 1279 house mouse
NP_501935     362 GVKGMVVDamtGEPIKRAVVWIRNgtetvpvkhPVTTWS-EGDFYRVLPAGKYEIIVAAEGYDIAA-KNVTVenkvrdsa 439  nematode
O75976       1214 GVHGFVKDk-tGKPISKAVIVLNEg-------iKVQTKE-GGYFHVLLAPGVHNIIAIADGYQQQH-SQVFVhhda-ass 1282 human
Q90240       1223 GVHGFVQDk-sGKAISKATIVLNEg-------lRVYTKE-GGYFHVLLAPGLHNINAIADGYQQKH-MKVLVrhda-pss 1291 mallard
CAF94141     1101 GVRGVVRDr-sGKPIAGAIVILNGg-------vRVFTTA-GGFYHALLAPGNHNLEVVAEGYQQHH-EEVTVsfyetakn 1170 Tetraodon nig...
P42787        763 GIHGFVHSt-iGTPIAGAVVRLDGan------hSTYSQV-FGDYWKLALPGRHNLTVLGDNYAPLR-MEVEVpdvh-pfe 832  fruit fly
XP_001812199  318 GVTGQILDratLKPIAHAALRVSGrn------iTFRTGK-TGEFWRLLLPGNYELEVTAEGYYDQSaPFVVRnfn--nsl 388  red flour beetle
1H8L_A        371 VQVNFTL 377  crested duck
ZP_01687231   481 IVKNVQL 487  Microscilla marina ATCC 23134
XP_966816     398 TVQNFTL 404  red flour beetle
O89001       1280 VVIVFDT 1286 house mouse
NP_501935     440 LVVNFAL 446  nematode
O75976       1283 VVIVFDT 1289 human
Q90240       1292 VFIVFDM 1298 mallard
CAF94141     1171 IIIELDM 1177 Tetraodon nigroviridis
P42787        833 MRMDITL 839  fruit fly
XP_001812199  389 PELTFLK 395  red flour beetle
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