1WYJ,3Q2W,1EDH,1L3W,2A4E,3MVS,2YST,1Q55,1L3W,3Q2V,3Q2W,1NCJ,1L3W,1FF5,2OMX,2YQG,2V37,3K5S,2A62,3PPE,3MVS,1L3W,1Q55,3Q2V,3Q2W


Conserved Protein Domain Family
Cadherin_repeat

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cd11304: Cadherin_repeat 
Click on image for an interactive view with Cn3D
Cadherin tandem repeat domain.
Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.
Statistics
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PSSM-Id: 206637
Aligned: 907 rows
Threshold Bit Score: 34.9818
Threshold Setting Gi: 74761344
Created: 16-Sep-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Comment:mediates cell-cell contacts
  • Comment:thought to be essential for trans-association
  • Structure:1FF5_A; Mus musculus E-Cadherin Double Domain binds three Ca2+
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ##                                                                 # #   
1WYJ_A      12 TITYSVLEETDr--gSLVGNL------AKDLGlslrelitRGAQILSKGnk----qLLQLEQksGNLLLKe-kLDREELc 78   house mouse
Q9NYQ8    1559 HYEASVPDTIAp--gTELLQVr-----AMDADrgv--naeVHYSLLKGNse----gFFNINAllGIITLAq-kLDQANH- 1623 human
Q9VW71    1300 VYKVQVPSSATv--nQSIFQVh-----AIDSDsge--ngrITYSIKSGKgk----nKFRIDSqrGHIHIA---KPLDSD- 1362 fruit fly
NP_497641 2446 SYTLQIPISTPa--gESVGQMq-----AIDEDggv--hgvVKYSISDRQs------TVKIEEhtGIIRLQkplVSRRNL- 2509 nematode
Q96JP9     250 PYYGYVYEDTLp--gSEVLKVv-----AMDGDrgk--pnrILYSLVNGNd-----gAFEINEtsGAISITq--SPAQLQr 313  human
Q8UVJ7     253 PYYGYVYEDTLp--gSEVLTVv-----ALDGDrgk--pnnIHYCIVNGSe-----gSFEISNttGAISVIk--SPNQLKk 316  chicken
Q6B457     254 PYYGYVYEDTTm--gSEVLTVk-----AYDGDrgn--pntIYYSIVNGSd-----gAFTINNatGGITVIk-tPDELKK- 317  African clawed frog
Q6B3P0     256 PYFGYVYEVSSp--gSEIFTVs-----AKDGDmdn--pntIIYSLDSGAd-----gSFSINKtsGVITLN---LYPADLr 318  zebrafish
1FF5_A       5 IPPISCPENEKgefpKNLVQI------KSNRDke----tkVFYSITGQGadkppvgVFIIERetGWLKVTq-pLDREAI- 72   house mouse
NP_733314  280 EYSASVPAGSL----LGVLTVlperiqAVDLDtin---spIRYSFASGMpgn-yadYFQIDEstGVLKQTk-aVDTSTA- 349  fruit fly
Feature 1                                          #          ## 
1WYJ_A      79 gstnpCILHFQVLLKSp--------vQFIQGEIQLQD---------VNDH 111  house mouse
Q9NYQ8    1624 -----APHTLTVKAEDqgsp---qwhDLATVIIHVYP---------SDRS 1656 human
Q9VW71    1363 -----NEFEIHIKAEDngip---kksQTARVNIVVVP---------VNPN 1395 fruit fly
NP_497641 2510 -----TIEQITVVAYSspt-----kqSKTTVYLEIGPfdvqpslpkLLLH 2549 nematode
Q96JP9     314 -----EVYELHVQVTEmspagspaaqATVPVTIRIVD---------LNNH 349  human
Q8UVJ7     317 -----EVYELRVQASEvspegdvsayAFATVTIRVVD---------LNNH 352  chicken
Q6B457     318 -----EVYELKIQVSEitpegdkvahAFTVATVRVVD---------LNNH 353  African clawed frog
Q6B3P0     319 ----rEVFNIKVKALEispegkrldfATTTVTIRVVD---------LNNH 355  zebrafish
1FF5_A      73 -----AKYILYSHAVSsnge---aveDPMEIVITVTD---------QNDN 105  house mouse
NP_733314  350 -----KKYDIIVKAEEvspg--pqrfTTAKLEIFVKP---------VDAN 383  fruit fly

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