Conserved Protein Domain Family
viperin
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TIGR04278: viperin 
antiviral radical SAM protein viperin
Viperin (Virus Inhibitory Protein, ER-associated, Iterferon-inducible) is a radical SAM enzyme found in human and other vertebrates. It is both induced by interferon and demonstrably active in blocking replication by several types of virus, apparently by modifying lipid chemistries in lipid droplets and membrane rafts.
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Statistics
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PSSM-Id: 212001
Aligned: 18 rows
Threshold Bit Score: 717.273
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001510936  14 LLQAFRDHLEGLWKS-IRWLSrWFRAVSIVEGSLRSRPQEEeekreREEEKKVEEGVPAGP-TIPISVNYHFTRQCNYKC 91  platypus
XP_426208     17 VLAALRGRLSALCWGlTPLVL-PLL--SWRRRS-------------GPDTPAAPREDKDETvPTPTSVNYHFTRQCNYKC 80  chicken
XP_003464994  13 MLSAFRPSLGSLWGSlASLLF-WLRAALWWPAEEKGCKQVA-----GEPQGSPEAKGEDS--TVPTSVNYHFTRQCNYKC 84  domestic guinea...
EHB15200      13 MLSTLRQPLGSLWGSlATLLC-WLRAALWWSAAEKGQQQLG-----GEPEGTREEEEEDG--TIPTSVNYHFTRQCNYKC 84  naked mole-rat
XP_003215459   8 LLRLLRLALAAFWSSyLAPTClWLSALPRRPSSLAAPAK-------ATPEDSTTTTPPPPPpLVPLSVNYHFTRQCNYQC 80  green anole
ABO48449      13 LLQHCISTLHCIVSSvFSVVCyWTAGACKGTTSP------------RRSVDSKLEQRKVQNaMTPTSVNYHFTRKCNYKC 80  Coreoperca whit...
NP_001020727  13 LMQLCVKNVQSFFLAlLR----WLSMQVSGAHVQQTPARKIs---rPESRTSKQKEGSRAPfTTPSSVNYHFTRQCNYKC 85  zebrafish
AAW82780      12 LLQLCLDTLHRIF-CfFSSVCfWTLRRLWATEGSH-----------VSPVDRKLGERQIQS-TTPASVNYHFTRKCNYKC 78  northern snakehead
ACQ58183      13 LLQLCIDSLRFMFASfFSKLYySTVYSETISS--------------VAPAASKVHQEKDRNvMTPTSVNYHFTRKCNYKC 78  sablefish
XP_002935073  12 MLSAVWGNFKFLLHSiNIFFF-W----CWLEILGKQKT--------SPLTRKPEPEDGTK--VKPTSVNYHFTRQCNYKC 76  western clawed ...

XP_001510936  92 GFCFHTAKTSFVLPLEEAKRGLRMLKEAGMEKINFSGGEPFLQNRGEFLGKMVKFCKEELRLSSVSVVSNGSLIRENWFK 171 platypus
XP_426208     81 GFCFHTAKTSFVLPLEEAKRGLAMLKEAGMEKINFSGGEPFLQDRGEFVGQLVQFCKEELKLPSVSIVSNGSLIRERWFK 160 chicken
XP_003464994  85 GFCFHTAKTSFVLPLEEAKKGLLLLKQAGMEKINFSGGEPFLQDRGEYLGKLVKFCKVELGLPSVSIVSNGSLIREKWFK 164 domestic guinea...
EHB15200      85 GFCFHTAKTSFVLPLEEAKRGLFLLKEAGMEKINFSGGEPFLQDRGEYLGKLVKFCKAELGLPSVSVVSNGSLIRERWFR 164 naked mole-rat
XP_003215459  81 GFCFHTAKTSFVLPLEEAQRGLRLLKEAGMEKINFSGGEPFLHERGNFVGKLVQFCKQELKLPSVSIVSNGSMIKERWFK 160 green anole
ABO48449      81 GFCFHTAKTSFVLPLEEAKRGLKLLKESGMEKINFSGGEPFLHDKGEFLGKLVEFCKLDLQLPSVSIVSNGSLIKEKWFQ 160 Coreoperca whit...
NP_001020727  86 GFCFHTAKTSFVLPIEEAKRGLRLLKEAGMEKINFSGGEPFVHQKGSFLGELVLYCKQELQLPSVSIVSNGSLIRESWFQ 165 zebrafish
AAW82780      79 GFCFHTAKTSFVLPLDEAKRGLKLLKASGMEKINFSGGEPFLHDRGEFLGKLVQFCKLDLQLPSVSIVSNGSMIKENWFQ 158 northern snakehead
ACQ58183      79 GFCFHTAKTSFVLPLDEAKRGLKLLKESGMEKINFSGGEPFLHDRGEFLGELVQYCKQDLQLPSVSIVSNGSTIKEEWFQ 158 sablefish
XP_002935073  77 GFCFHTAKTSFVLPIEEAKRGLTMLKAAGMEKINFSGGEPFLQERGHYVGKLVQFCKEELKLPSVSIVSNGSLITERWFK 156 western clawed ...

XP_001510936 172 CYGEHLDILAISCDSFDEQVNVLIGRGQGKKSHVENLQKLRNWCQHYGVAFKINSVINRFNFEEDMNEQIKVLNPVRWKV 251 platypus
XP_426208    161 KYGEYLDILAISCDSFNEEVNVLIGRGQGRKNHVENLHKLRQWCRDYAVAFKINSVINRFNVEEDMNEQIKALNPVRWKV 240 chicken
XP_003464994 165 DYGDYLDILAISCDSFNEHVNVLIGRGQGKKNHVEKLQKLNEWCKQYKVAFKINSVINRFNVDEDMREHIKALNPVRWKV 244 domestic guinea...
EHB15200     165 DYGEYLDILAVSCDSFDEQECPHIGRGQGKRNHVENLQKLNKWCKEYKVAFKINSVINRFNVEEDMREHIKVLNPVRWKV 244 naked mole-rat
XP_003215459 161 HYGEYLDILAVSCDSFFEEVNVLIGRGQKGKNHIENLHKLKQWCQRYGVAFKINSVINRFNMEEDMNEQIRALNPVRWKV 240 green anole
ABO48449     161 KYGEYLDILAISCDSFDEATNQLIGRAQGRKSHIDNLYKIRSWCQQYKVAFKINSVINTFNVDEDMSEAITQLSPVRWKV 240 Coreoperca whit...
NP_001020727 166 KYGDYLDILAISCDSFIEETNQLIGRAQGRKSHLDNLHKVRNWCREYKVAFKINSVINTYNVEEDMTEQITALNPVRWKV 245 zebrafish
AAW82780     159 KYGDYLDILAISCDSFDETTNQLIGRTQGRKSHVDNLFKIRNWCQQYKVAFKINSVINTFNVDEDMREQITELNPVRWKV 238 northern snakehead
ACQ58183     159 KYGDDLDILAISCDSFDESTNQLIGRTQGGKSHIDNLHKIRSWCQQYKVAFKINSVINTFNMYEDMTENILQLNPVRWKV 238 sablefish
XP_002935073 157 LYGEYLDILAVSCDSFNEDVNKLIGRGQGKKNHVENLLKIRQWCQDYNVAFKINSVINRYNVDEDMNDEISLINPIRWKV 236 western clawed ...

XP_001510936 252 FQCLIIDGENSGEDALREAEKFIISDEDFEQFLERHKEIACLVPESNQKMKDSYLILDEYMRFLNCRNGRKEPSRSILDV 331 platypus
XP_426208    241 FQCLIIEGENSGEDALREADKFVISDEDFEQFLERHKDISCLVPESNQKMRDSYLILDEYMRFLNCRNGRKEPSKSILDV 320 chicken
XP_003464994 245 FQCLLIEGENCGEDALREAERFVISEEEFEAFLERHKEVPCLVPESNQKMKDSYLILDEYMRFLNCTQGRKEPSKSILDV 324 domestic guinea...
EHB15200     245 FQCLLIEGENCGKDALREAERFLISEEEFEGFLERHREVSCLVPECNQKMKDSYLILDEYMRFLNCRQGSKDPSRSILDV 324 naked mole-rat
XP_003215459 241 FQCLLIEGENSGEDALREAERFVISDEDFEQFLKRHQGLSCLVPESNQKMKDSYLILDEYMRFLNCVNGRKEPSRSILDV 320 green anole
ABO48449     241 FQCLLIDGENAGETALREAERFVISDQLFQEFLDRHSSVSCLVPESNEKMRNSYLILDEYMRFLDCREGRKDPSKSILDV 320 Coreoperca whit...
NP_001020727 246 FQCLLIEGENAGENSLREAEKFVISDQQFQDFLERHQSIQCLVPESNQKMRDSYLILDEYMRFLDCREGRKDPSKSILDV 325 zebrafish
AAW82780     239 FQCLLIDGENAGEAGLREAERFVISDQQFEEFLDRHSSVSCLVPESNEKMRNSYLILDEYMRFLDCREGRKDPSKSILDV 318 northern snakehead
ACQ58183     239 FQCLLIDGENAGEKALREAERFVISEQLFQEFLERHSSVPCLVPESNEKMRNSYLILDEYMRFLDCREGRKDPSKSILDV 318 sablefish
XP_002935073 237 FQCLIIEGENAGEEALRQVETFIISNKEFKGFLDRHRNIKCLVPESNEQMRNSYLILDEYMRFLDCRNGRKDPSKSILDV 316 western clawed ...

XP_001510936 332 GVQEAIKFSGFDEKMFLKRGGKYVWSKAELNLQW 365 platypus
XP_426208    321 GVEAAIKFSGFDEKMFLKRGGKYVWSKADMILDW 354 chicken
XP_003464994 325 GVEQAIKFSGFDEKMFLKRGGKYVWSKEDMKLDW 358 domestic guinea pig
EHB15200     325 GVEQAIRFSGFNEKMFLRRGGKYVWSKADMKLDW 358 naked mole-rat
XP_003215459 321 GVQDAIQFSGFDEKMFLKRGGKYVWSKVDMALEW 354 green anole
ABO48449     321 GVKEAICFSGFDEKMFLKRGGKYVWSKADMKLQW 354 Coreoperca whiteheadi
NP_001020727 326 GVEEAIKFSGFDEKMFLMRGGKYVWSKADMKLEW 359 zebrafish
AAW82780     319 GVKEAICFSGFDEKMFLKRGGKYVWSKADMKLEW 352 northern snakehead
ACQ58183     319 GVKKAICFSGFDENMFLKRGGKYVWSKADMKLEW 352 sablefish
XP_002935073 317 GIDNAIQFSGFDEKMFFKRGGKYVWSKADLRLEW 350 western clawed frog
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