Conserved Protein Domain Family
RasGAP_IQGAP3

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cd12207: RasGAP_IQGAP3 
Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 3
This family represents the IQ motif containing GTPase activating protein 3 (IQGAP3), which associates with Ras GTP-binding proteins. A primary function of IQGAP proteins is to modulate cytoskeletal architecture. There are three known IQGAP family members: IQGAP1, IQGAP2 and IQGAP3. Human IQGAP1 and IQGAP2 share 62% identity. IQGAPs are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP is an essential regulator of cytoskeletal function. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity, the protein actually lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite of their similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3, only present in mammals, regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.
Statistics
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PSSM-Id: 213346
Aligned: 4 rows
Threshold Bit Score: 657.287
Created: 27-Oct-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative RAS
Feature 1:putative RAS interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                     #                              # # #
Q86VI3        987 EAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLED 1066 human
XP_002187447 1068 ESVIFTLYNYASNPREAYLLLQLFKVALQEEIRSKVDHVHDILTGNATVVRLVVSFYRSERGQNALRHILAGPVQEVLQD 1147 zebra finch
XP_002938989  992 ESVTFTLYNYASNRREAYLLLKLFRTALQEEINSKVDKVQDIITGNPTVIRLLVSFYRSARGQNALRHILGNVVKEVIQD 1071 western clawe...
CAF95047     1027 EMLVFSLFSYGSDSREAFLLLQLFTEALRLEISLKVEKPQDVITGNPAVIKMLVNFYRHAGGQNALRDCLGPALQDLLLD 1106 spotted green...
Feature 1         #  #  #   #                                                                     
Q86VI3       1067 KVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRY 1146 human
XP_002187447 1148 RALSIHTDPVDIYKAWVNQTESQSGHRSKLPYEVSPEQALSHPEVQRRLDISIRNLLAVTDKFVSAITSSVDKIPYGMRY 1227 zebra finch
XP_002938989 1072 KTLNIRMNPVEIYKTWINQVETQTGKKSTLPYDVTPEQALTHQEVQRRMDICIRNLIAVTDKFFSTILANVDQIPYGMRY 1151 western clawe...
CAF95047     1107 PGLSIRTDPLQVYRAWINLSETQSGCRSSLPYEVSPAEALRHPEVRRRVEVAAVNLRSLTDRVLNAVTSSLGKLPYGLRY 1186 spotted green...
Feature 1                               #       ##  ##  #                        #  ##  #   # #   
Q86VI3       1147 VAKVLKATLAEKFPDATDsEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAggalaapQRHALGAVAQLLQHAAAGKAFs 1226 human
XP_002187447 1228 MAKILRMSLVEKFPKAPAeEVDKIVGNLLYYRFMNPAVVAPDGFDIVDVSAgaalrpeQRRSLGCIAKVLQHAAAHRPFq 1307 zebra finch
XP_002938989 1152 VAKVLKNSLSQKFPSAQEhDIHKIVGNLLYYRFMNPAVVAPDAFDIIDLSAggtlhpdQRRTLGSIAKVLQHAAANKMF- 1230 western clawe...
CAF95047     1187 SAKVLRDALQAKFPGASEdELYKVVGNLVYYRYMNPAIVAPDGFDVLDCSAasalqpeQRRMLGSVSRMLQHAAANKHFq 1266 spotted green...
Feature 1          ##                                                                             
Q86VI3       1227 gQSQHLRVLNDYLEETHLKFRKFIHRACQvpe-peeRFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQ 1305 human
XP_002187447 1308 gDSAHLCGLNQYLEHTHSKFRRFISAACCvpe-peeRFDMDEYSEMVAVAKPVIYITVGELINTHKLLLEHQDSITSHHS 1386 zebra finch
XP_002938989 1231 -EDSHLGLLNQYLEETYWKFRKFIRTACTvpe-peeRFNIDEYSEMVNMTKPVIYITVGELIDTHKLLVEHQDSIAPDHK 1308 western clawe...
CAF95047     1267 gDGEHVQALNQYISQTHVRFPVRFLQCVCdvpepaqRYNVDEFSELLSLNKPVIYMSVSELLNTHKLLLEHQEALCGDPS 1346 spotted green...
Feature 1                                        
Q86VI3       1306 DPLHELLEDLGELPTIPDLIGESIAADGHTD 1336 human
XP_002187447 1387 DPLHELLADLDELPTVQSLVGESVASLGDSS 1417 zebra finch
XP_002938989 1309 DPIHELLEDIGEVPTVQSLIGESTSNLSDVG 1339 western clawed frog
CAF95047     1347 DPLRLLLQDLGCVPTLQEVAGESWPDPGSDP 1377 spotted green pufferfish

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