1Z8G,2CGA,1NPM,1L2E,1YBW,1A5I,1FDP,2ODP,2WIN


Conserved Protein Domain Family
Tryp_SPc

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smart00020: Tryp_SPc 
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Trypsin-like serine protease
Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Statistics
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PSSM-Id: 214473
View PSSM: smart00020
Aligned: 189 rows
Threshold Bit Score: 120.09
Threshold Setting Gi: 116116
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1Z8G_A    117 RIVGGR-DTSLGRWPWQVSLRYdg--------------aHLCGGSLLSGDWVLTAAHCFpeRNRv-------lSRWRVFA 174 human
O17489    107 RVLGGQ-PTKIDEFPWTALIEYekpn---------grfgFHCGGSVINERYILTAAHCI--TSipr-----gwKVHRVRL 169 African malaria mo...
O01654    471 QASGGKiIKRRGEWPWMTLVDLgdneakgkygisglngtNYCGGSLVDENIVITAAHCV--ELRnp-------sDITAWF 541 Halocynthia roretzi
Q31430    469 RIAGGD-PTKIELWPWQAQISMrvhisn------dhvkpAFCGGSIIAEQWILTAAHCF--DEFaitddewwrGSIDVVI 539 Lethenteron japonicum
NP_508030  15 ESCGIQqESKIKNFPWAVSFTVdg--------------vNRLGGSIISPYHIITAAHG-----------------FITTI 63  nematode
NP_500999  37 RIIGGN--SIDDGANWMAKLVSygdn----------gqgILCGATVIDDFWLVTAAHCA--L--------------QLQT 88  nematode
AAB94558  160 LIVGGV-NASRNEFPHMVLLGFnttt----------gisWMCGGSLISEKFILTAGHCV--MHKd---------FGDVKY 217 tobacco hornworm
AAB94560   27 GVAGGH-EIPISDAPFVASIIRyknktq------pkttvMIFGGSVIHERFILTAAHCF--LMYen------lTSEVIRV 91  tobacco hornworm
AAB94559   30 GIYGGH-DISIEQAPFMASLRLng-------------tdHYCGASVIHERFILTAAHCI--LPDr---------KYTVQV 84  tobacco hornworm
P13582    127 RIYGGM-KTKIDEFPWMALIEYtksq---------gkkgHHCGGSLISTRYVITASHCV--NGKalp---tdwRLSGVRL 191 fruit fly
1Z8G_A    175 GAVAQASPHGL---------------------------------------------------Q-LGVQAVV-YHGGYlpf 201 human
O17489    170 GEWDLSSTTDQeddfy------------------------------------------adapIdLDIEKII-VHPGY--- 203 African malaria mo...
O01654    542 GVDDRSINDNIv--------------------------------------------------QkRDILEIN-IHQDY--- 567 Halocynthia roretzi
Q31430    540 GSSNKLGGDKIs-------------------------------------------------pKqIIIHEGYnRNPDA--- 567 Lethenteron japonicum
NP_508030  64 GSRGNLCENKNwkkpnssiyrsikflrdtrkvayggtcirghtdkypndprckksdvihnkvRaVLVDGEFaSSNCL--- 140 nematode
NP_500999  89 RSFVYVREPKNnr------------------------------------------------eRsFSVKEAY-IHSGY--- 116 nematode
AAB94558  218 ASIGVLSRGEVtp------------------------------------------------eNtYKVKRSV-RHPQY--- 245 tobacco hornworm
AAB94560   92 GSAQLGVGG-----------------------------------------------------TtYEVEKVI-IHENF--- 114 tobacco hornworm
AAB94559   85 GTTYANDGG-----------------------------------------------------QvYDVEKIM-KHEMY--- 107 tobacco hornworm
P13582    192 GEWDTNTNPDCevdvrgm-------------------------------------kdcapphLdVPVERTI-PHPDY--- 230 fruit fly
1Z8G_A    202 rdpNS-----EENSNDIALVHLSSPlpLTEYIQPVCLPAA--------------------------GQALVD-GKIcTVT 249 human
O17489    204 ---NLq---dKSHHNDIALIRFNREinYSSTIRAICLPLSn------------------------sLRNRKHaGLSsYAA 253 African malaria mo...
O01654    568 ---ENkr-htTPFDSDIAVLKLDSPvtLTPVVRPICLPLTetekqlp-------------qksqnpQHNVNT-WYKgVVT 629 Halocynthia roretzi
Q31430    568 ---HVq---iENLDNDIALIKLSKRltFGYTYRPICLPCTketnaildlnsankdwttlcnihgknLIDVKK-NTSlTVT 640 Lethenteron japonicum
NP_508030 141 ---KG---------HDWAIVEVEKRihFSENVRPICLPRP---------------------------NMYYT--KSlAVP 179 nematode
NP_500999 117 ---NN-----QTADNDIALLRISSDlsKLG-IKPVCLVHDd-------------------------SKLLKQ-YKNgVVI 161 nematode
AAB94558  246 ---R------IDVYNDIAVIELEKEvtLDAFTVPACLHVG---------------------------DPIDY--SRaIAA 287 tobacco hornworm
AAB94560  115 ---NPnnnmsLAFSHDIALLKLKEKycLHE-MYLNSLADK--------------------------DLEIVP-YTLaNVT 163 tobacco hornworm
AAB94559  108 ---NY-----TTHDYDICLIKLKTNltFSAKVNKIDLADR--------------------------SVRLKQ-NIQvEVT 152 tobacco hornworm
P13582    231 ---IPa---sKNQVNDIALLRLAQQveYTDFVRPICLPLDv------------------------nLRSATFdGITmDVA 280 fruit fly
1Z8G_A    250 GWGNTQY------Y-GQQAGVLQEARVPIISNDV---CNG---ADFYG------NQIKPKMFCAGYPE----GGIDACQG 306 human
O17489    254 GWGKTET--------ASASQKKLKVELTVVDVKD---CSP---VYQRNg-----ISLDSTQMCAGGVR-----GKDTCSG 309 African malaria mo...
O01654    630 GWGKTEVg--------TLSNHLLKVRLPFVSNEV---CQTgydELYEH------ITITENMICAGYPG----GHRDACKG 688 Halocynthia roretzi
Q31430    641 GFGLLEGd-------KKHAQQLQQATVQYAKKEV---CLKdimARFNVteekaeKHITENMLCAWNAT------ADTCRG 704 Lethenteron japonicum
NP_508030 180 GWGRifn--------------esGPLIHEIPMRIdrdCKR---PWSDRl-----PADADDFICATSMNvsnySAPRTCHG 237 nematode
NP_500999 162 GYGLTLGedssgePkLINSQTLQSTSVPIISDDD---CVKtwrFLSLLs-----VKITGYQICAGAYL------HGTAPG 227 nematode
AAB94558  288 GWGLLED------RgATPSDVMQKVIVKKIRKVT---CQR---DYPGDtsavaaKYDSESQLCYGDRQ----EKKDTCHG 351 tobacco hornworm
AAB94560  164 GWVDLAIr--------QYFKDTT-ASISRDKPIDe--CK-----MYP--------WACKDEICIKSYN------KGSCKG 213 tobacco hornworm
AAB94559  153 GWGATS-------AdGDISNNLQQVTIPIISTFSc--CLK---YLKVR------HAITSRMFCAGEQ------GKDSCQG 208 tobacco hornworm
P13582    281 GWGKTEQ--------LSASNLKLKAAVEGSRMDE---CQN---VYSSQd-----ILLEDTQMCAGGKE-----GVDSCRG 336 fruit fly
1Z8G_A    307 DSGGPFVCEDsisrtpRWRLCGIVSWGt------GCA-LAQKPGVYTKVSDFREWI 355 human
O17489    310 DSGGPLMRQMt----gSWYLIGVVSFGp-----qKCG-APGVPGVYTNVAEYVDWI 355 African malaria mosquito
O01654    689 DSGGPLMFPDri--tnTWFLNGIVSFGdssdrenFCG-QARTYGAYTNVGKFIDWI 741 Halocynthia roretzi
Q31430    705 DSGGPLVLQKn----rRWIQVGIVAGGva----qHCG-KNIKSSFYTNVAKMMPWV 751 Lethenteron japonicum
NP_508030 238 DSGGGLEYRDdn--ygRAFLIAITSFGt-----rGCP--SNMLARFTRVDMYLNLI 284 nematode
NP_500999 228 DSGGPLLIHKsn---gEYVQIGITSYGadg--ldGVIdQGKFPGvytriskyvpwi 278 nematode
AAB94558  352 DSGGPLQLKHkki-ncMYLVIGVTSGGk------GCA-LRNRPGLYSKVSHYLDWI 399 tobacco hornworm
AAB94560  214 DSGGPLTMHG--------VQVGIVSNGl------GCG---TMPTIHTKISFLRPWI 252 tobacco hornworm
AAB94559  209 DSGGPLTLNN--------VQVGVTSFGs------GCG---KLPGVYTKISAMLPWI 247 tobacco hornworm
P13582    337 DSGGPLIGLDtnkvntYYFLAGVVSFGp-----tPCG-LAGWPGVYTLVGKYVDWI 386 fruit fly
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