Conserved Protein Domain Family
DAGKa

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smart00045: DAGKa 
Diacylglycerol kinase accessory domain (presumed)
Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain might either be an accessory domain or else contribute to the catalytic domain. Bacterial homologues are known.
Statistics
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PSSM-Id: 214486
Aligned: 14 rows
Threshold Bit Score: 234.152
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002089537 1004 IINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDL--ANg-pHLQ 1080 Drosophila ya...
BAA11134      719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGDPSHS--P----VLQ 792  human
XP_003097380  831 VMNNYFGIGLDAKIALEFHNKREE-SEKTRSRSKLFMWYGILGGKELMHRTYRNLEQRIKLECDGVPIDL--P----SLQ 903  Caenorhabditi...
XP_002642410  578 IINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNKLWYFELGTSETLSSSCKNLHEQIDILCDGESIDLgqDA---SLE 654  Caenorhabditi...
XP_001162820  463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTP--KIqdlKPQ 540  chimpanzee
NP_001188565  959 VINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRNLSQWVTLECDGQDFTG--KLrdaGCH 1036 fruit fly
NP_495301     572 VMTNYFSIGADAHVALQFHHSRSANPQMLNSRLKNRIAYGGLGTIDLFKRSWKDLCEYITLECDGVDVTP--RIkelKLH 649  nematode
BAA09856      507 YMTNYIGVGCDAKVALEIHNLREENPERFYSQFMNKVLYAREGARSIMDRTFEDFPWQVRVEVDGVDIEV--PE---DAE 581  thale cress
XP_001171847  369 TMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVAL--P----SLE 442  chimpanzee
XP_001085047  868 QMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKI--SHSRSLHKQIRLQVERQEVEL--P----SIE 939  rhesus monkey
XP_002089537 1081 GVALLNIPYTHGGSNLWG----------------EhlsqkrirksagpfgkskklragdkefsatsFNSVDLSVAIQDFG 1144 Drosophila ya...
BAA11134      793 GIAVLNIPSYAGGTNFWG----------------G-------------------------------T-KEDDTFAAPSFD 824  human
XP_003097380  904 GIVILNIPSYSGGANFWG----------------R--------------------------------NKDGPEFTVQSFD 935  Caenorhabditi...
XP_002642410  655 GIALLNIPSIYGGSNLWGrsrkskgrmpglfpmkN-------------------------------AEKMQLQTRVQDIG 703  Caenorhabditi...
XP_001162820  541 CVVFLNIPRYCAGTMPWG----------------H-------------------------------PGEH-HDFEPQRHD 572  chimpanzee
NP_001188565 1037 AVLFLNIPSYGGGTHPWN----------------D-----------------------------------SFGASKPSID 1065 fruit fly
NP_495301     650 CILFHNITYYAGGTIPWG----------------E-------------------------------SSD-----NKPSCC 677  nematode
BAA09856      582 GILVANIGSYMGGVDLWQ----------------N-------------------------------EDETYENFDPQSMH 614  thale cress
XP_001171847  443 GIIVLNIGYWGGGCRLW-------------------------------------------------EGMGDETYPLARHD 473  chimpanzee
XP_001085047  940 GLIFINIPSWGSGADLWG-------------------------------------------------SDSDTRFEKPRMD 970  rhesus monkey
XP_002089537 1145 DRLIEVIGLENCLHMGQVRtG---LRAS-GRRLAQCSEVi--IKTKKTFPMQIDGEP 1195 Drosophila yakuba
BAA11134      825 DKILEVVAVFGSMQMAVSR-V---IRLQ-HHRIAQCRTVkisILGDEGVPVQVDGEA 876  human
XP_003097380  936 DRILEVVALFGVIHVATSR-VpnaVRLQ-NHRIAQCRHVrivILGDEPIPVQVDGEP 990  Caenorhabditis remanei
XP_002642410  704 DGLIELVGLESAMQMGQIK-A---GVRG-ARRLSQCSTVv--IQTHKSFPMQIDGEP 753  Caenorhabditis briggsae
XP_001162820  573 DGYLEVIGFTMTSLAAL---Q---VGGH-GERLTQCREVv--LTTSKAIPVQVDGEP 620  chimpanzee
NP_001188565 1066 DGLMEVVGLTTYQLP--ML-Q---AGMH-GTCICQCRKAr--IITKRTIPMQVDGEA 1113 fruit fly
NP_495301     678 DGKVEVLGFTTATLAAL---Q---MGGK-GERIAQCSRVr--vITNKAIPMQVDGEP 725  nematode
BAA09856      615 DKIVEVVSISGTWHLGK-L-Q---VGLSrARRLAQGSAVkiqL--CAPLPVQIDGEP 664  thale cress
XP_001171847  474 DGLLEVVGVYGSFHCAQI--Q---VKLAnPFRIGQAHTVrliLKCS-MMPMQVDGEP 524  chimpanzee
XP_001085047  971 DGLLEVVGVTGVVHMGQVQ-G---GLRS-GIRIAQGSYFrvtLL--KATPVQVDGEP 1020 rhesus monkey
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