2XBB,3G1N,1C4Z


Conserved Protein Domain Family
HECTc

?
smart00119: HECTc 
Click on image for an interactive view with Cn3D
Domain Homologous to E6-AP Carboxyl Terminus with
E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Statistics
?
PSSM-Id: 214523
Aligned: 25 rows
Threshold Bit Score: 367.715
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2XBB_A         53 DFLk--AR---LWIEFdG--EkGLDYGGVAREWFFLISKEMFNPY-----YGLFE-----------------YSATDnY- 102  human
A38920        549 DLKk--Q----LYVEFeG--EqGVDEGGVSKEFFQLVVEEIFNPD-----IGMFT-----------------YDEST-K- 596  human
XP_001100859  726 DLKk--P----LKVIFdG--EeAVDAGGVTKEFFLLLLKELLNPI-----YGMFT-----------------YYQDS-N- 773  rhesus monkey
XP_001927286 4450 DLRlpsRA---WKVKLvG--EgADDAGGVFDDTITEMCQELETGI-----VDLLI-----------------PSPNA-Ta 4501 pig
NP_012570     545 LLKs-------LRIEFvN--EpGIDAGGLRKEWFFLLTKSLFNPM-----NGLFI-----------------YIKES-Sr 592  Saccharomyces...
AAH49162     1155 hgrengadsildlglLdS--SeKVQENRKRHGSSRSVVDMDLEDTddgddNAPLF-----------------YQPGK-R- 1213 house mouse
NP_501120    2355 adRk--AV---LEIEYtN--EeG-TGLGPTLEFYALVAAELQRKS-----LALWV-----------------CDDDD-T- 2402 nematode
AAB88625     2554 TLRq--KVneaIEIITfKqkSeTSAQSSQPKKSPSVVVVDPVDDD-----NEPLF-----------------YSPGK-R- 2607 fruit fly
EDN59898     1120 kygsspdV---LEIEYq---EeAGTGLGPTLEFYSVVSKYFARKS-----LNMWR-----------------CNSYS-Yr 1170 Saccharomyces...
XP_003274764 1659 DLGs--SRa-mLEIQYeN--E-VGTGLGPTLEFYALVSQELQRAD-----LGLWRgeevtlsnpkgsqegtkYIQNL-Q- 1725 White-cheeked...
2XBB_A        103 --------------T----------------------------LQINPNSGLcNEDHL----S--Y---FKFIGRVAGMA 131  human
A38920        597 --------------L----------------------------FWFNPSSFEtEG----------Q---FTLIGIVLGLA 621  human
XP_001100859  774 --------------L----------------------------LWFSDTCFVeH--------N--W---FHLIGITCGLA 798  rhesus monkey
XP_001927286 4502 evg-------ynrdR----------------------------FLFNPSACL--DEHL----M--Q---FKFLGILMGVA 4535 pig
NP_012570     593 -------------sW----------------------------FAIDPPNFDkSKGKN----S--QlelYYLFGVVMGLA 625  Saccharomyces...
AAH49162     1214 --------------G----------------------------FY-TPRPGKnTEARL----N--C---FRNIGRILGLC 1241 house mouse
NP_501120    2403 --------------HasksgeerevdlgegkkpigyyvrrvggLFPAPLPPGtDETKR----AadM---FRVLGVFLAKV 2461 nematode
AAB88625     2608 --------------G----------------------------FYI-PRQGFaSFERI----N--A---FRNIGRLIGLC 2635 fruit fly
EDN59898     1171 semdvdttddyittL----------------------------LFPEPLNPFsNNEKV----Ie-L---FGYLGTFVARS 1214 Saccharomyces...
XP_003274764 1726 --------------G----------------------------LFALPFGRTaKPAHIakvkM--K---FRFLGKLMAKA 1758 White-cheeked...
2XBB_A        132 VYHGKLLDGFFIRPFYKMM-------------LH--KPI------------TLHDMESVDSEYYNSLRWI---------- 174  human
A38920        622 IYNNCILDVHFPMVVYRKL-------------MG--KKG------------LFVDLGDSHPVLYQSLKDL---------- 664  human
XP_001100859  799 IYNSTVVDLHFPLALYKKL-------------LN--VKP------------GLEDLKELSPTEGRSLQEL---------- 841  rhesus monkey
XP_001927286 4536 IRTKKPLDLHLAPLVWKQL-------------CC--VPL------------TLEDLEEVDLLYVQTLNSIl--------- 4579 pig
NP_012570     626 IFNSTILDLQFPKALYKKL-------------CS--EPL------------SFEDYSELFPETSRNLIKMlnytedn--- 675  Saccharomyces...
AAH49162     1242 LLQNELCPITLNRHVIKVL-------------LG--RKV------------NWHDFAFFDPVMYESLRQLi--------- 1285 house mouse
NP_501120    2462 LLDGRLVDLPLSRPFLKLLvhpqigddargpnLH--KIL------------SLDDFEEVNPVKGSFLKELralaq----- 2522 nematode
AAB88625     2636 LLQNELLPLFLQRHVLKYI-------------LR--RKI------------KFHDLAFFDPALYESFRQIi--------- 2679 fruit fly
EDN59898     1215 LLDNRILDFRFSKVFFELL-------------HR--MSTpnvttvpsdvetCLLMIELVDPLLAKSLKYIv--------- 1270 Saccharomyces...
XP_003274764 1759 IMDFRLVDLPLGLPFYKWM-------------LRqeTSL------------TSHDLFDIDPVVARSVYHLedivrqkkrl 1813 White-cheeked...
2XBB_A        175 ----------LE------NDPT------------------------E-------LD---LRF-I-----IDEELFGQTHQ 198  human
A38920        665 ----------LE------YVGN------------------------Ve------DDm-mITFqI-----SQTNLFGNPMM 692  human
XP_001100859  842 ----------LD------YPGE------------------------Dv------EEtfcLNFtI-----CRES-YGVIEQ 869  rhesus monkey
XP_001927286 4580 ----------HI------ED-S------------------------Gi------TE---ESFhEmipldSFVGQSADGKM 4609 pig
NP_012570     676 ----fedvfsLT------FETT------------------------Yr------NN---NWI-L-----NDSKSSKEYVT 706  Saccharomyces...
AAH49162     1286 ----------LA------SQSS------------------------DadavfsaMD---LAFaI-----DLCKEEGGG-Q 1316 house mouse
NP_501120    2523 ------rkrlIE------NDTSidsnskrrkiaelklhikgstcrvEd------LA---LNFtV-----NPPSKVFQYAE 2576 nematode
AAB88625     2680 ----------QNaqtkegEETI------------------------Nr------ME---LCFvI-----DLMKEEG-CGN 2710 fruit fly
EDN59898     1271 ----------AN------KDDN--------------------------------MT---L-EsL-----SLTFTVPGNDD 1293 Saccharomyces...
XP_003274764 1814 eqdksqtkesLQ------YALE------------------------Tl-----tMNg-cSVEdL-----GLDFTLPGFPN 1852 White-cheeked...
2XBB_A        199 HELKNGGSEIVVTNKNKKEYIYLVIQWR-FVNRIQKQMAAFKEGFFELIP-Q-DLIK-IFDENELELLMCG--LG--DVD 270  human
A38920        693 YDLKENGDKIPITNENRKEFVNLYSDYI-LNKSVEKQFKAFRRGFHMVTN-E-SPLKyLFRPEEIELLICG--SR--NLD 765  human
XP_001100859  870 KKLIPGGDNVTVCKDNRQEFVDAYVNYV-FQISVHEWYTAFSSGFLKVCG-G-KVLE-LFQPSELRAMMVG--NS--NYN 941  rhesus monkey
XP_001927286 4610 VPIIPGGNSIPLTFSNRKEYVERAIEYR-L-HEMDRQVAAVREGMSWIVP-V-PLLS-LLTAKQLEQMVCG--MP--EIS 4680 pig
NP_012570     707 VELCENGRNVPITQSNKHEFVMKWVEFY-LEKSIEPQYNKFVSGFKRVFA-EcNSIK-LFNSEELERLVCG--DE--EQT 779  Saccharomyces...
AAH49162     1317 VELIPNGVNIPVTPQNVYEYVRKYAEHR-MLVVAEQPLHAMRKGLLDVLP-K-NSLE-DLTAEDFRLLVNG--CG--EVN 1388 house mouse
NP_501120    2577 MELVDGGSDIDVTIDNVEQYVEKCEEFY-LNTGIAYQMRAFRDGFDRVFP-L-RTLR-AYSPEEVQRLLSGeqCP--EWS 2650 nematode
AAB88625     2711 RELIPGGRDV-VSHRVIYSSTSDAIQNIdXIKSQEKALEALKDGVFDVLP-D-NSMI-NLTAEDLRLLLNG--VG--DIN 2782 fruit fly
EDN59898     1294 IELIPGGCNKSLNSSNVEEYIHGVIDQI-LGKGIEKQLKAFIEGFSKVFSyE-RMLI-LFPDELVDIFGRV--EE--DWS 1366 Saccharomyces...
XP_003274764 1853 IELKKGGKDIPVTIHNLEEYLRLVIFWA-LNEGVSRQFDSFRDGFESVFP-L-SHLQ-YFYPEELDQLLCG--SKadTWD 1926 White-cheeked...
2XBB_A        271 VND---WREHTKYKNgYSANHQVI----QWFWKAVLMMDSEKRIRLLQFVTGTSRVP--MNGFAELYGsngpqSFTVEQW 341  human
A38920        766 FQA---LEETTEYDGgYTRDSVLI----REFWEIVHSFTDEQKRLFLQFTTGTDRAP--VGGLGKL-------KMIIAKN 829  human
XP_001100859  942 WEE---LEETAIYKGdYSATHPTV----KLFWETFHEFPLEKKKKFLLFLTGSDRIP--IYGMASLQ-------IVIQST 1005 rhesus monkey
XP_001927286 4681 VEV---LKKVVRYRe-VDEQHQLV----QWFWHTLEEFSNEERVLFMRFVSGRSRLP--AN-TADISQ-----RFQIMKV 4744 pig
NP_012570     780 KFDfksLRSVTKYVGgFSDDSRAV----CWFWEIIESWDYPLQKKLLQFVTASDRIP--ATGISTIPF-----KISLLGS 848  Saccharomyces...
AAH49162     1389 VQM---LISFTSFNDeSGENAEKLlqfkRWFWSIVEKMSMTERQDLVYFWTSSPSLPasEEGFQPM-P-----SITIRPp 1459 house mouse
NP_501120    2651 RDD---ILNYTEPKLgYTRESPGF----LRFVDVMEALTAQERKNFLQFATGCSSLP--PGGLANLHP-----RLTIVRK 2716 nematode
AAB88625     2783 VST---LISYTTFNDeSSEGPDKLxkfkKWFWSIVEKMNIMERQHLVYFWTGSPALPasEEGFQPL-P-----SVTIRPA 2853 fruit fly
EDN59898     1367 MAT---LYTNLNAEHgYTMDSSII----HDFISIISAFGKHERRLFLQFLTGSPKLP--IGGFKSLNP-----KFTVVLK 1432 Saccharomyces...
XP_003274764 1927 AKT---LMECCRPDHgYTHDSRAV----KFLFEILSSFDNEQQRLFLQFVTGSPRLP--VGGFRSLNP-----PLTIVRK 1992 White-cheeked...
2XBB_A        342 Gt-P------EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENT-----QG-F 382  human
A38920        830 Gp-Dt-----ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA-----KG-F 871  human
XP_001100859 1006 As-Ge-----EYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNY-----EG-F 1047 rhesus monkey
XP_001927286 4745 Dr-Py-----DSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCrsidmDN-Y 4791 pig
NP_012570     849 H--Ds-----DDLPLAHTCFNEICLWNYSSKKKLELKLLWAINES-----EG-Y 889  Saccharomyces cerevisiae S288c
AAH49162     1460 ---Dd-----QHLPTANTCISRLYVPLYSSKQILKQKLLLAIK-T-----KN-F 1498 house mouse
NP_501120    2717 VesGd-----GSYPSVNTCVHYLKLPEYSSSAILRERLLTAINE------KG-F 2758 nematode
AAB88625     2854 ---Dd-----SHLPTANTCISRLYIPLYSSKSILRSKMLMAIKS------KN-F 2892 fruit fly
EDN59898     1433 Ha-EdgltadEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEG-----AGaF 1480 Saccharomyces cerevisiae YJM789
XP_003274764 1993 Tf-EstenpdDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGq----QS-F 2040 White-cheeked Gibbon
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap