3KSY,3QXL


Conserved Protein Domain Family
RasGEF

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smart00147: RasGEF 
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Guanine nucleotide exchange factor for Ras-like small GTPases
Statistics
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PSSM-Id: 214539
View PSSM: smart00147
Aligned: 35 rows
Threshold Bit Score: 170.889
Threshold Setting Gi: 74833723
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3KSY_A        776 LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSP---------NLLKMIRHTTNLTLWFEKCIVETEN-L 845  human
Q21758        193 VLCNDAKTVAQQLTHIEMERFSMVGVDEIVQSLASDPLSEIGRHsknkegtisSISFYIEWFNRLSAFAAIEVLKQTK-K 271  Caenorhabditi...
O75815        544 FTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITlph---ghqLRLDIIERHNTMAIGIAVDILGCTGtL 620  human
O44235        565 LLSVDPFKLARHMTVIDCKV-CRIMEGELENALLPHGHq--------------LRQDIIERYQCIAFWVAICVIKCTNhG 629  Halocynthia r...
AAD03422      768 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-KTTa--------NLDLFLRRFNEIQFWVVTEICLCSQ-L 837  human
XP_002815303  932 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA----------NLKRFEEVINQETFWVASEILRETN-Q 1000 Sumatran oran...
NP_067722     619 LDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTa--------NLERFMRRFNELQYWVATELCLCPV-P 689  Norway rat
AAL09435      767 LLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKYG--Sp--------KLEEFEQLFNREMWWVATEICTERH-V 835  nematode
P34578        791 LHLIDSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPf--------NLDLLVRRFNEVQHWSTTEILLATE-- 860  nematode
NP_011082     592 DITTLADEVHHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNPlvfn--ndqNIHFLGRLLISHLFPTNPEFSKKVT-P 668  Saccharomyces...
3KSY_A        846 EERVAVVSRIIEILQVFQE-LNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQ----KKILEEAHEL--S-E-DHYKKYL 916  human
Q21758        272 RNRVAVFEFMIDIAKECCE-IGNFNSMMAIVAGLSLPAVSRLKKTWCRVEKAKl---EILQHQLDPS------GNFLSYR 341  Caenorhabditi...
O75815        621 EDRAATLSKIIQVAVELKDsMGDLYSFSALMKALEMPQITRLEKTWTALRHQY----TQTAILYEKQlkP-FsKLLHEGR 695  human
O44235        630 RERVDMLNTFIQVANELVHsMGNVFGFSAIMHGLTCPQVSSLDISWESLHRKYtnnaVTYDKKLRPLlrY-L-DEGKGQI 707  Halocynthia r...
AAD03422      838 SKRVQLLKKFIKIAAHCKE-YKNLNSFFAIVMGLSNIAVSRLALTWEKLPSKF----KKFYAEFESLmdP-S-RNHRAYR 910  human
XP_002815303 1001 LKRMKIIKHFIKIALHCRE-CKNFNSMFAIISGLNLAPVARLRTTWEKLPNKY----EKLFQDLQDLfdP-S-RNMAKYR 1073 Sumatran oran...
NP_067722     690 GPRAQLLRKFIKLAAHLKE-QKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV----RKLYSALERLldP-S-WNHRVYR 762  Norway rat
AAL09435      836 QKRAKLIKKFIKVARYCRD-LRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKY----IRMLDEIHQLvdP-S-RNMSKYR 908  nematode
P34578        861 ENRMEILKKFISIATIARE-YRDLLTVFAITLGLSHTSISRLTLTWSKLPPAS----LKTFSELENLldP-T-RNHRMYR 933  nematode
NP_011082     669 KVRAELLDKWVQIGCRFEH-LGDMVSWLAVATIICSIPVLRSSSWKYVPDQSL----KTIFKDWVPTiiQlE-RRQRTSK 742  Saccharomyces...
3KSY_A        917 AKLRSIN-----------PP-----------CVPFFGIYLT--NILKTEEGNPEVLKrhgK------------------E 954  human
Q21758        342 ATIKAAQwradsargnqqKI-----------VIPFFVLLLK--DLFLIYHGHPRILP---N------------------A 387  Caenorhabditi...
O75815        696 E--STCVppn-----nvsVP-----------LLMPLVTLME--RQAVTFEGTDMWEK----------------------- 732  human
O44235        708 RHSSVCI-----------PH-----------IMPFTR-LLE--NPGPGIPHASTGET---AakraasfgslldrtisslG 759  Halocynthia r...
AAD03422      911 LTVAKLE-----------PP-----------LIPFMPLLIK--DMTFTHEGNKTFI----D------------------N 944  human
XP_002815303 1074 NVLNSQNl---------qPP-----------IIPLFPVIKK--DLTFLHEGNDSKV----D------------------G 1109 Sumatran oran...
NP_067722     763 LALTKLs-----------PP-----------VIPFMPLLLK--DMTFIHEGNHTLVE----------------------N 796  Norway rat
AAL09435      909 QHLAEVAq---------ePP-----------VVPIYPVIKK--DLTFAHDGNATYSE----------------------K 944  nematode
P34578        934 LLVSKMs-----------SP-----------YIPFVPLILK--DLMFIHQGNKSF-Y---N------------------G 967  nematode
NP_011082     743 STSSVFIl----------APpnldddftranVISYFGDLLIhaDDLPSDTKFKYLEK---Kin---------------rT 794  Saccharomyces...
3KSY_A        955 LINFSKRRKVAEITGEIQQYQN--QPYCL-----RVE------------SDIKRFFENln-----------pmGNSME-- 1002 human
Q21758        388 HLNFMAFNQLAEQLRDVIQWKS--TVCTF-----EKNp-----------QVLQYLLIT---------------SVSGE-- 432  Caenorhabditi...
O75815        733 --NDQSCEIMLNHLATARFMAEaaDSYRM-----NAErilagfqpdeemNEICKTEFQmrllwgskgaqvnqtERYEK-- 803  human
O44235        760 NEDTASLNSTGRDVVKADWWEN--RPNES-----FDSllg-------hmNSGRLLIQHl--------------DDFKK-- 809  Halocynthia r...
AAD03422      945 LVNFEKMRMIANTARTVRYYRS--QPFNPdaaqaNKNh-----------QDVRSYVRQl--------------NVIDN-- 995  human
XP_002815303 1110 LVNFEKLRMIAKEIRHVGRMAS--VNMDP-----ALMf-----------RTRKKKWRSlgslsqgstnatvldvaqtggh 1171 Sumatran oran...
NP_067722     797 LINFEKMRMMARAVRMLHHCRSh-STAPL-----SPLrs--------rvSHIHEDSQAs-------------rISTCS-- 847  Norway rat
AAL09435      945 LINFEKLRLIAKSIRGVMKLSS--APYEI-----ASMa----------eRSGGVVMDAl--------------lHMNS-- 991  nematode
P34578        968 LVNFEKMHMFAKIFRSFRQCKS--QMDNGa----EHEf-----------IEPQSLIRNl--------------RVIDN-- 1014 nematode
NP_011082     795 KNAFHKWQQRLQAIDSTRHKTN--STENV-----RDNd-----------SPNNVVYQLw-------------kFHLSQpp 843  Saccharomyces...
3KSY_A       1003 --KeftdYLFNKSLEIEPRN 1020 human
Q21758        433 --K----DSMLMSFECEPPE 446  Caenorhabditis elegans
O75815        804 --Fn--qILTALSRKLEPPP 819  human
O44235        810 --Na---NSKLVDFKEYPKV 824  Halocynthia roretzi
AAD03422      996 --Qr---TLSQMSHRLEPRr 1010 human
XP_002815303 1172 kkrvrrssflnakklyedaq 1191 Sumatran orangutan
NP_067722     848 --Eq---SLSTRSpastway 862  Norway rat
AAL09435      992 --Fe---NSNVATMRKgmsg 1006 nematode
P34578       1015 --Qk---KLMQLSYEIEPKS 1029 nematode
NP_011082     844 lnIe---GIMKLSVQHEPPI 860  Saccharomyces cerevisiae S288c
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