3FCS,3FCS,3IJE


Conserved Protein Domain Family
Int_alpha

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smart00191: Int_alpha 
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Integrin alpha (beta-propellor repeats).
Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.
Statistics
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PSSM-Id: 214549
View PSSM: smart00191
Aligned: 124 rows
Threshold Bit Score: 31.5769
Threshold Setting Gi: 16329757
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FCS_A         15 NGSQFGFSLDfHKDSHG--RVA-IVVGAPRTLGpsq----eetGGVFLCPWRAE--GGQCPSLLFD 71   human
XP_003253848  302 lGSYFGASVCaV-DLNAdgFSD-LLVGAPMQSTir------eeGRVFVYINSGS--GAVMNametn 357  White-cheeked Gibbon
XP_002826908  604 MGSYFGSELCpV-DIDMdgTTDfLLVGAPFYHVhg------eeGRVYVYRLSEQ--DGSFSLARIL 660  Sumatran orangutan
NP_012403     334 SFSDFGTSLT-MGKFREd-NKDyLAVSAPLEDt---------vGAIYIVPWDILt-VARKEDFSIL 387  Saccharomyces cerevisiae S288c
NP_728021     303 IGEYFGYSLA-TSDVDGdgLDD-LLIGAPMYTDpdnvegkydvGRVYILLQGGPteEKRWTTEHIR 366  fruit fly
AAA16099      265 MGSYFGSSLC-AVDLNGdgLSD-LLVGAPMFSEir------deGQVTVYINr---gNGALEEQLAL 319  human
AAH96347      453 IGAYFGASLC-SVDVDSngSTDlVLIGAPHYYEqtr----ggqVSVCPLPr----gRARWQCDAVL 509  human
AAP88867      373 IGSYFGGELC-GVDVDQdgETElLLIGAPLFYGeq------rgGRVFIYQr----rQLGFEEVSEL 427  synthetic construct
P53710        476 IGSYFGSVLC-AVDVNKdtITDvLLVGAPMYMNdlk----keeGRVYLFTi----tKGILNWHQFL 532  cattle
EDM10391      237 IGSYFGSVLT-TIDIDKdsYTDlLLVGAPMYMGtek----eeqGKVYVYAv----nQTRFEYQMSL 293  Norway rat
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