3QIJ,3IVF,1H4R,2I1J,3PVL,2J0M,3PZD


Conserved Protein Domain Family
B41

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smart00295: B41 
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Band 4.1 homologues
Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.
Statistics
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PSSM-Id: 214604
View PSSM: smart00295
Aligned: 62 rows
Threshold Bit Score: 72.713
Threshold Setting Gi: 74956422
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3QIJ_A         19 HCKVSLLDDT--VYECVVEKHAKGQDLLKRVCEHLNL-------LEE-DYFGLAIWD-NATs-------------K---- 70   human
O24147        280 TTIVFFLDET--FEEITYDMATTVADAIEEVAGIIKL-------SAH-ASFSLFECRkVVTgskspd---pgneeY---- 342  common tobacco
Q20456       2242 RQAFYISKDH--NVSQTLRPITVAEEMIQELCNLLNVrs----lHEQ-QEFSLCYTVgKDKh-------------L---- 2297 Caenorhabditi...
P90536        282 TCKIRFIDQS--TKLAKINTYTTIREITDTVCRQYGIs-----qQSI-KMFGISAVNeTAGis----------kvV---- 339  Dictyostelium...
O00522        421 KVRIYRMDGSyrSVELKHGNNTTVQQIMEGMRLSQETqqyftiwICS-ENLSLQLKPyHKPlq----------hvR---- 485  human
XP_001087868 1311 MLPVTFMDGT--TKTLLTDSATTAKELCNALADKISL-------KDR-FGFSLYIALfDKVsslgsgsdhvmdaiS---- 1376 rhesus monkey
NP_508420    1174 VLAVTFMDGS--VKTLCADSATTAAELCKQLAEKVGL-------TNS-FGFSLYIALfDKVsslgsgtdhvmdaiS---- 1239 nematode
BAG58507      580 TSTVYCHGGG--SCKITINSHTTAGEVVEKLIRGLAMe------DSR-NMFALFEYNgHVDk-------------Aiesr 637  human
3PVL_A        265 MLPVTFMDGT--TKTLLTDSATTARELCNALADKISL-------KDR-FGFSLYIALfDKVsslgsgsdhvmdaiS---- 330  house mouse
3PZD_A        201 TSTVYCHGGG--SCKITINSHTTAGEVVEKLIRGLAM-------EDSrNMFALFEYNgHVDkaiesrt-vvadvlA---- 266  human
3QIJ_A         71 --------TWLDSAKEIKKQ-VRg-----------VPWNFTFNVKFYPPD--------PAQLTEDITRY--YLCLQLRQD 120  human
O24147        343 --------ICLDENKYIGDLlEDfkalkdrskgeiLHCKLSFKKKLFRES--------DEAVTEPMFVQ--LSYVQLQHD 404  common tobacco
Q20456       2298 --------NYCKNDNYLMDIiTEseh-------kkLPFQFYLKRTVWVHP-----------LRYDNAAYidSMFDQVIDD 2351 Caenorhabditi...
P90536        340 --------SETDMIYDVLARwEQse--------ekGEFYFQVRRRFFLDDvnkildqeHLWTDDDICFE--LTYCQIRDE 401  Dictyostelium...
O00522        486 --------DWPEILAELTNLdPQr-----------ETPQLFLRRDVRLPLe-------VEKQIEDPLAIl-ILFDEARYN 538  human
XP_001087868 1377 --------QCEQYAKEQGAQeRN------------APWRLFFRKEVFTPW--------HS-PSEDNVATn-LIYQQVVRG 1426 rhesus monkey
NP_508420    1240 --------QCEQYAKEQGRQeRN------------APWRLFFRKEIFSPW---------HDPRDDPVSTn-LIYQQVIRG 1289 nematode
BAG58507      638 tvvadvlaKFEKLAATSEVGd--------------LPWKFYFKLYCFLDT--------DNVPK-DSVEFa-FMFEQAHEA 693  human
3PVL_A        331 --------QCEQYAKEQGAQeRN------------APWRLFFRKEVFTPW--------HN-PSEDNVATn-LIYQQVVRG 380  house mouse
3PZD_A        267 --------KFEKLAATSEVGd--------------LPWKFYFKLYCFLDT--------DNVPK-DSVEFa-FMFEQAHEA 314  human
3QIJ_A        121 IVAGRLPCS----------FA-TLALLGSYTIQSELGDYDPElh---gvDYVSD-------------FKLAP-------- 165  human
O24147        405 YIMGNYPVG----------KD-DAAQMSALQILVDIGYVDGPesc--tdWTSLL-------------ERFLP-------- 450  common tobacco
Q20456       2352 YLRGSLISTnslgqltaatTE-EIIKLAAYLFLLL-PDNPKGl------NAKTL-------------PQIVP-------- 2402 Caenorhabditi...
P90536        402 WMKGLYTNVn---------EK-DSSIIAAILIQLLYPNQSKLv-----lTKEVV-------------RQVLP-------- 445  Dictyostelium...
O00522        539 LLKGFYTAP----------DA-KLITLASLLLQIVYGNYESKkhkqgflNEENL-------------KSIVP-------- 586  human
XP_001087868 1427 VKFGEYRCE----------KEdDLAELASQQYFVDYGSEMILe-----rLLNLV-------------PTYIP-------- 1470 rhesus monkey
NP_508420    1290 IKYGEYRCDk---------DE-ELAAICAQQYYIDEGTMDVNk------lENNL-------------PSYLP-------- 1332 nematode
BAG58507      694 VIHGHHPAP----------EE-NLQVLAALRLQYLQGDYTLHaai--ppLEEVYslqrlkarisqstKTFTPcerlekrr 760  human
3PVL_A        381 VKFGEYRCE----------KEdDLAELASQQYFVDYG---SEmil--erLLSLV-------------PTYIP-------- 424  house mouse
3PZD_A        315 VIHGHHPAP----------EE-NLQVLAALRLQYLQGDYTLHaai--ppLEEVY-------------SLQRL-------- 360  human
3QIJ_A        166 ----NQT--------KEL-----------EEK---------------------VMELHK-SY-----RS-M--TPAQA-D 191  human
O24147        451 ----RQIamt--rakREW-----------ELD---------------------ILSRYK-LM-----EN-L--TKDDA-K 482  common tobacco
Q20456       2403 ----KSViepkhrhqEEM-----------VTR---------------------ISRQLK-MFg----GR-M--RPAEA-K 2437 Caenorhabditi...
P90536        446 ----DQIlns--qniKVW-----------ISM---------------------IESQIF-EL-----VS-Q--TPEYL-K 477  Dictyostelium...
O00522        587 ----VTKlks---kaPHW-----------TNR---------------------ILHEYK-NLstsegVS-K--EMHHL-Q 622  human
XP_001087868 1471 ----DREitpl-ktlEKW-----------AQL---------------------AIAAHK-KG-----IYaQ--RRTDA-Q 1504 rhesus monkey
NP_508420    1333 ----DFEmsgkemalEKW-----------TQT---------------------IMHQYRkKF-----TG-RlpSQIEV-K 1369 nematode
BAG58507      761 tsflEGTlrrsfrtgSVV-----------RQKveeeqmldmwikeevssarasIIDKWR-KF-----QG-M--NQEQA-M 819  human
3PVL_A        425 ----DREitpl-knlEKW-----------AQL---------------------AIAAHK-KG-----IYaQ--RRTDSqK 459  house mouse
3PZD_A        361 ----KARisqs-tktQMLdmwikeevssaRAS---------------------IIDKWR-KF-----QG-M--NQEQA-M 404  human
3QIJ_A        192 LE--FLENAK-KLS-MYGVDLH 209  human
O24147        483 QQ--FLRILR-TLP--YGNSVF 499  common tobacco
Q20456       2438 SH--FLELLS-TWP-TFGVLHY 2455 Caenorhabditis elegans
P90536        478 LM--FINLIG-SKSpLFGCTLF 496  Dictyostelium discoideum
O00522        623 RM--FLQNCW-EIP-TYGAAFF 640  human
XP_001087868 1505 -K--VKEDVV-NYA-RFKWPLl 1521 rhesus monkey
NP_508420    1370 EN--VVSVAKtKWP-LLFSRFY 1388 nematode
BAG58507      820 AK--YMALIK-EWP-GYGSTLF 837  human
3PVL_A        460 VKedVVNYARfKWP-LLFSRFY 480  house mouse
3PZD_A        405 AK--YMALIK-EWP-GYGSTLF 422  human
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