3DUI,1X50,3I8T,3GAL,3NV1,3NAJ,3NAJ,2D6K,1KJL,1GZW,2JJ6,1HLC,1QMJ,1QKQ


Conserved Protein Domain Family
Gal-bind_lectin

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smart00908: Gal-bind_lectin 
Click on image for an interactive view with Cn3D
Galactoside-binding lectin
Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.
Statistics
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PSSM-Id: 214904
View PSSM: smart00908
Aligned: 190 rows
Threshold Bit Score: 56.8304
Threshold Setting Gi: 25145209
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DUI_A        10 NLGLKPGQ---RLTVKGIIAPNAK-SFVMNL-------------------------G---------K-----D---STH- 42  chicken
XP_001656933  99 iteVSPGL---SFIISGSILLTCE-RFSINL-------------------------M---------L-----K---NSD- 131 yellow fever mo...
AAL28440      10 SHPLEFGH---VLEVVAKTIDGAA-RFHINL-------------------------C---------TakstvDp--NAD- 48  fruit fly
XP_001655869  10 SCTVEAGQ---IFVISARPIDDAE-RVNINF-------------------------L---------S-----GksdEAD- 45  yellow fever mo...
XP_001660453  11 PTKPKSGD---EILLRAKLKDDAV-RFSVNF-------------------------ClsrpegiseC-----Hs--PPH- 53  yellow fever mo...
EAL38639      11 PRYPENGD---EVFIRGKLKDDAK-SFSVNF-------------------------ClprpaqvaeH-----Qt--PPY- 53  Anopheles gambi...
XP_001660452  11 PRKPAVGD---EVIVKGMLKPDAR-VFSVNLilpqappvqkslsapsesdvkssqkC---------C-----Ap--LPTn 70  yellow fever mo...
NP_001023191  17 YEGMREHS---SVEIHGEVFQGPQgGFTVEF-------------------------P---------T-----Kn--G--- 49  nematode
XP_001660451  17 PKQPKYGD---EIAIKGVLQNDAE-RFSINL-------------------------Cldr---pdgC-----Dp--NDEp 57  yellow fever mo...
NP_732131     11 PTNASTSDrvtRLSISGNLLQDPQ-QFSVNF-------------------------V---------N-----Sp-dCTDn 49  fruit fly
3DUI_A        43 -----LGLHFNPRF---DA----HgdvnLIVCNSKKMEEWG-------TEQR-E---T---------------------- 77  chicken
XP_001656933 132 -----LALHFNPRL---PQ----N----YIVRNCRVKGVWG-------KEEV-A---S---------------------- 162 yellow fever mo...
AAL28440      49 -----IGLRFSCYF---RN----D----VIVRNSRINGAWG-------EEES-H---Vmdp------------------- 82  fruit fly
XP_001655869  46 -----IILHLSIRF---HD----D----IIVRNSKLGGVWGgeereenLNEL-T---A---------------------- 83  yellow fever mo...
XP_001660453  54 -----IAYHFRTDFfdnEE----S----VTIHNWKNGGFWQ-------AEIE-E---P---------------------- 87  yellow fever mo...
EAL38639      54 -----IALHFKTIY---DErddtS----RVVLNWK-NLQWQ-------QEEVlD---N---------------------- 88  Anopheles gambi...
XP_001660452  71 hswpyIAYHFKVVF---NDdg-sS----IVVQNWK-NVVWQ-------NERR-T---L---------------------- 108 yellow fever mo...
NP_001023191  50 -----VALHISVRMgsyGQ----N----VIVFNHLQRGRWH-------REE--H---H---------------------- 82  nematode
XP_001660451  58 e---wIAYHFGLDF---TEgd-gN----CRVTQCSKNVNWN-------SP------------------------------ 89  yellow fever mo...
NP_732131     50 -----ITYHFKVVI---PT----Q----TIIENYKRNGEWS-------SLHQ-EkylNifdgtgasdknpnmtesfarii 105 fruit fly
3DUI_A        78 -----V--FPFQ-KGA-PI-----EITFSINPSDLTVHL-P--G----HQ---FSFPNRLGLSVFDYFDTHGDFTLRSVS 133 chicken
XP_001656933 163 -----PlsFNLH-RGQ-KF-----NIQILVTDKEFLMCV-N--Gr---HF---NTFKHRLPYKKICALEVKGDVKDVNVE 221 yellow fever mo...
AAL28440      83 --ntlP--NPIV-SGE-FF-----LVYILCCEDSFAISI-N--Sr---EF---CRFRYRMPLGTIRALEIRDQIQVikqv 142 fruit fly
XP_001655869  84 -----P--NPTT-PGD-VF-----KLYILIGDDRFHIAI-N--Gh---PY---CTYGFRAALSEIRTITVVKDVQqivqm 140 yellow fever mo...
XP_001660453  88 -----N--NWISdRSA-VF-----CLIFRFHEEYIKVFAeD--Tq---HTp-dYEFEHQYPMEAIKMIELWDDFEyveel 148 yellow fever mo...
EAL38639      89 -----Y--WHVD-RSQ-TF-----RVVFRLHEDCIKVFV-NsvDh---PPd--YQFPVQLPLDQIESIELWDDVEhveei 148 Anopheles gambi...
XP_001660452 109 -----G--HNFKdRTK-PF-----TIIFRFHHDTIRVFI-D--Ht---HHvpdYEFEYELPLERIRLVEIWDDVlyveev 169 yellow fever mo...
NP_001023191  83 -----Q--NTIM-FGR-PF-----CMRIHNEHRKYSIHV-D--Gh---HI---GHYHHHKCPKRIVAMTVRGDLRVGKIH 139 nematode
XP_001660451  90 ---------LFA-DGE-VFngrtvNVILRLEEESIKVFYeD--Tq---HVa-dYEYSHQLPIEQIRTIELRDGIaqveei 152 yellow fever mo...
NP_732131    106 teideA--LQLS-STEsSF-----CLEFAFDYANSMMRVyQ--GrdsgHNf-iTEYETLFSLSDIQAVQVWGDVQKVNQF 174 fruit fly
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