Conserved Protein Domain Family
Telomerase_RBD

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smart00975: Telomerase_RBD 
Telomerase ribonucleoprotein complex - RNA binding domain
Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.
Statistics
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PSSM-Id: 214948
Aligned: 27 rows
Threshold Bit Score: 112.351
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAK60396      455 RVVNFLRLYLIKV--------LPKN-ILGTFK-NfKTFINKKIPIIVNLH----IRETFKIQHAMNGIEVSnwvnrilee 520  Cryptosporidi...
AAD54276      452 QVVSFIWAICRYI--------VPES-LLGTTH-Q-MRVLRKNIAWFVSRR----RNEKCTVNQFLHKVKPS--------- 507  thale cress
NP_986041     262 LVTRLILVLVDKI--------VPLE-LFGSKR-N-KAKLFKRISELLALN----LNSRMPFAYVITGINTN--------- 317  Ashbya gossyp...
XP_502732     358 DVVSFCFAASHLL--------FPHV-LFGSAD-N-WAVLRSKYVYYLNLP----SRTSPHLDTMTGGFRLT--------- 413  Yarrowia lipo...
XP_458163     263 VVIRFVLIVTGKI--------FPLN-TWGTPK-N-KSEVIKKIVRFIKAG----KNDKFLKDQLISSIQLS--------- 318  Debaryomyces ...
XP_829083     387 RVPPRFVGGAVTA--------DRVK-FWGEE-----GTVLTRLREVTVDWlccgRHEVFLLSHFLDGVPVS--------- 443  Trypanosoma b...
XP_444808     262 CVNKFIVVILEKL--------KILQ-LIGSRK-N-SFVLFSKISQLLKLP----LNGKINVKEFFTKLNVN--------- 317  Candida glabr...
XP_001469622  498 vVVSYLRTLLSTLrwaplkeaKNRS-FWGRDAaG-SERVLDALMGAVRNWliagRHAIVPVSRFLDGVPVA--------- 566  Leishmania in...
XP_628872     488 LVYRFLITITNRL--------FCKNkVWGSEY-N-QKCFNQGLIIFLNQT----SNKKLKFNSFCKRFNLN--------- 544  Dictyostelium...
CAL36061      273 RVLKFIIVILQKL--------LPQE-MFGSKK-N-KGKIIKNLNLLLSLP----LNGYLPFDSLLKKLRLK--------- 328  baker's yeast
AAK60396      521 kSYQF---IKESK-----NlinsnqrskkvpnnkTRs-------------SIKKSLISLGKTYLARNIYFLIVYLVFPIL 579  Cryptosporidi...
AAD54276      508 -DFPF---FARKElccmvN---------------GHe-------------LQSESIRSTQQMLCTKWISWLFLEIVKKLV 555  thale cress
NP_986041     318 -DIMW---DAGSC-----S---------------N------------------------RQIYFEDFVYWLVRTFIPRLV 349  Ashbya gossyp...
XP_502732     414 -EINW---LFTSD-----M---------------NLk-------------K-SRDDMLKARELFEQLMIWVTNRFLPQIL 455  Yarrowia lipo...
XP_458163     319 -HIYW---L---G-----K---------------TSe-------------ITSKQDYKLRVSLFSSFMEWFLSVYICKLV 358  Debaryomyces ...
XP_829083     444 -RIPW---LRGFY-----T---------------KEp--------------ARKRRSMIQQRVFLQLVLFLYQCVVPFLI 485  Trypanosoma b...
XP_444808     318 -AVRRylsIDPIG-----Q---------------QKq-------------SMRLY--------LTCVVNYLLSKLIPSLL 355  Candida glabr...
XP_001469622  567 -QVPW---LNGFY-----T---------------TTpslpfsaatssaarHARRERSHVQQRVWLQFVLFLTQDILPFLL 622  Leishmania in...
XP_628872     545 -QFLF---GTN-----------------------------------------------CSIIYFKRFMWWLFEEIIPSII 573  Dictyostelium...
CAL36061      329 -DFRW---LFISDi------------------------------------WFTKHNFENLNQLAICFISWLFRQLIPKII 368  baker's yeast
AAK60396      580 RRHFYATEIEG---SNKVRYFRHPVWIKIVRQADKWYLE 615  Cryptosporidium parvum
AAD54276      556 HFNFYATESQGg--RLNIYYYRKRSWERLISKEISKALD 592  thale cress
NP_986041     350 GSIFYCSELSSq---VTTVYIRQDVWREISRPFLNWYFQ 385  Ashbya gossypii ATCC 10895
XP_502732     456 RSFFYFTDSl----TSDQIIYRHPVWQRKTRSTLQELKR 490  Yarrowia lipolytica CLIB122
XP_458163     359 GSFWYVTEVSHgilSKDILHYPHNEWKRITNKWLNDYVK 397  Debaryomyces hansenii CBS767
XP_829083     486 RRSFHVACTSKs--PYIFFFIPRAVWVRLTRREMRRvci 522  Trypanosoma brucei TREU927
XP_444808     356 KSFFYCTEVSSy--S-KILYFRNDEWNSISTPFLKEYLD 391  Candida glabrata CBS 138
XP_001469622  623 RASFTITWSSKn--THKLLFFPAFVWrrlirrevrrtrs 659  Leishmania infantum JPCM5
XP_628872     574 RNYFYCTESTD---SLKLLYFRKVDWFKLAGIQSQNLsf 609  Dictyostelium discoideum AX4
CAL36061      369 QTFFYCTEISS---TVTIVYFRHDTWNKLITPFIVEYFK 404  baker's yeast
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