19075844 369 SAWATFKPFEKQFWKIKKDLMDTVVFFQKGKFYELYENDAAIGHQVFSLKLTDRVN-----MKMVGIPEASFDYWASQFI 443 fission yeast 15896285 -------------------------------------------------------------------------------- Clostridium aceto... 15896798 -------------------------------------------------------------------------------- Clostridium aceto... 15927623 -------------------------------------------------------------------------------- Staphylococcus au... 19112759 9 ANERTDEARMFNFYEKMPKDTNTVRVFDRGEFYVAIGEDASFVAQNAYHTTSVLKHhnvsnTSYCNLSPSLFIKFAEDVL 88 fission yeast 19112758 -------------------------------------------------------------------------------- fission yeast 13541505 -------------------------------------------------------------------------------- Thermoplasma volc... 13541506 -------------------------------------------------------------------------------- Thermoplasma volc... 14318519 1 -------------------MSESNLSSFISTNYFNLRSAANSSNSISKPSTKKSIRnqkspTNISSWALKKKTLQIAETT 61 baker's yeast 2506880 11 SDVSEERNFYKKYTGLPKKPLKTIRLVDKGDYYTVIGSDAIFVADSVYHTQSVLKNcq--ldPVTAKNFHEPTKYVTVSL 88 baker's yeast
19075844 444 A-KGYRIARVDQLETALGKEIkdrqrtqkeekVVQR--GLTQVLTSGTLVDEAMLtSDLstyCMAIKESLQSDNEEp--- 517 fission yeast 15896285 -------------------------------------------------------------------------------- Clostridium aceto... 15896798 -------------------------------------------------------------------------------- Clostridium aceto... 15927623 -------------------------------------------------------------------------------- Staphylococcus au... 19112759 89 SnLAKRVEIWGANSAKTGFELlkq-----aspGNMQ--MLEDLLVSENYQESTAI-SDSs--VSSVLLAVTTRVKQdq-- 156 fission yeast 19112758 -------------------------------------------------------------------------------- fission yeast 13541505 -------------------------------------------------------------------------------- Thermoplasma volc... 13541506 -------------------------------------------------------------------------------- Thermoplasma volc... 14318519 62 WeNNEKDSTHSHYLMTGSMAS-----------RTAT--SLSRYSTNASLLGPSID--------CVLCCIYEVPRDIs--- 117 baker's yeast 2506880 89 QvLATLLKLC--LLDLG-YKVe----------IYDKgwKLIKSASPGNIEQVNEL-MNMnidSSIIIASLKVQWNSqdgn 154 baker's yeast
19075844 518 -SFGICFIDTSTGGFHMCEFTddihRTKLDTLLTQVRPKELILEKSKISQK---------SIRAIKYCvssssiwnFIKP 587 fission yeast 15896285 1 ---------MDKNEEFLRRIEn---FKSEKSKLKQNYNMMSLLRFIVF------------IMAISFTY--------FLVK 48 Clostridium aceto... 15896798 -------------------------------------------------------------------------------- Clostridium aceto... 15927623 -------------------------------------------------------------------------------- Staphylococcus au... 19112759 157 rIIGVAFIDPILKKLGVSEFVdsdaYTNFEALIVQVGAKECIISQSGHESTngnsavsinTAEINRLRniiegcgaLVTT 236 fission yeast 19112758 -------------------------------------------------------------------------------- fission yeast 13541505 -------------------------------------------------------------------------------- Thermoplasma volc... 13541506 -------------------------------------------------------------------------------- Thermoplasma volc... 14318519 118 tRIGLCIINCNTGQMYLSDFMdsqiYIRVVHKLQIYQPTEILIPSSSLAPT---------VSKLATMIkfnvaetvKIEE 188 baker's yeast 2506880 155 cIIGVAFIDTTAYKVGMLDIVdnevYSNLESFLIQLGVKECLVQDLTSNSNs--------NAEMQKVInvidrcgcVVTL 226 baker's yeast
19075844 588 YTEFWDNERVEREIIAGDYFKNGLEGAPKILksylseKPLAISAFGALFWYLrq----lkLDKDMCSMGNFDEYDASQQS 663 fission yeast 15896285 49 NPSIFILLG---TILSFVLFVYILKIHEKIS--------DRLEVANNLVEVN---------EKYLKRIDGTWTSFQDFGE 108 Clostridium aceto... 15896798 1 ---------MDEDKLYMYSAIATLALG--IS---------AFVFFQLAIGYK----------NYIYFLGTALSIAAIFLA 50 Clostridium aceto... 15927623 1 ------------------------------------------------------------MSTNQTFLIFVIAIILLTSV 20 Staphylococcus au... 19112759 237 IRSSEFSARDVELELSKVLDSPVTHALVPELg-----LQLAMASCNALLRYLgpallnpdMEDDRENTSRKLHLYHHNLE 311 fission yeast 19112758 -------------------------------------------------------------------------------- fission yeast 13541505 -------------------------------------------------------------------------------- Thermoplasma volc... 13541506 -------------------------------------------------------------------------------- Thermoplasma volc... 14318519 189 GSRKCFNSQDGLAAITKYLMDDTKKDLKIEEii---dKTFALCAASAAISYMeei---isKSSRNLNAFRKLRIQFEGTE 262 baker's yeast 2506880 227 LKNSEFSEKDVELDLTKLLG-DDLALSLPQKy-----SKLSMGACNALIGYL--------QLLSEQDQVGKYELVEHKLK 292 baker's yeast
19075844 664 TSLLMNGQTLKNLEIFSNS------------FDGGSEG------TLFHLLCRCVTPFGKRLFHTWLCHPLRSGTAINARL 725 fission yeast 15896285 109 EFQDEEYPYLGDLDIFGKK-------------------------SLFQLINTCVTFLGRKKLAETLKKPDKNIEKIRMRQ 163 Clostridium aceto... 15896798 51 FYMKAKIIHKLNYERFKRY-----------------WGe-----FQKRKRNTRNVKKFFEFHKEDNADEFNVDEQTWEDL 108 Clostridium aceto... 15927623 21 IGIVGRYMSRQRLLKSMET------------LWQTISP------LEAFIRPNSHFDYEYKLYKEKFESHSLVDDKTWSDL 82 Staphylococcus au... 19112759 312 QYMRLDIAAVRSLNLLPPP------------NGNAHKTm-----SLYGLLNHCRTAMGARNLRRWIVQPLLDAKSIERRH 374 fission yeast 19112758 -------------------------------------------------------------------------------- fission yeast 13541505 1 -----------------------------------------------MVFNSILWPDKKAESLFDSDPDFFADLNLDMII 33 Thermoplasma volc... 13541506 1 ---------------------------------------------MNVDLLFNDTDGRVNESVPWNSNDLEKDLDLEILY 35 Thermoplasma volc... 14318519 263 NTMLIDSKTVRGLELVENK--------------LDKNGi-----SLWKFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRL 323 baker's yeast 2506880 293 EFMKLDASAIKALNLFPQGpqnpfgsnnlavSGFTSAGnsgkvtSLFQLLNHCKTNAGVRLLNEWLKQPLTNIDEINKRH 372 baker's yeast
19075844 726 DVVELIADNP-VIRDTIWG---FLHKLPDLERLISRVHAGRSKPADFVRVLEGFQRINSAFDQLREEFMEV-----AEGT 796 fission yeast 15896285 164 KAVEELKD------------------KIDFCQNVESQGNSNELGTDPSELFNDLENTEHLFKNFLVEAFIR------ILP 219 Clostridium aceto... 15896798 109 NMNKVFELADrTLTSPGEe---MLYKIFKTPEFSKEKLLERNSIIKIFQNNKEVREKVGLELIKLGRKKENg----VTDL 181 Clostridium aceto... 15927623 83 NMNAIFHKMN----YNLT----AIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYP-----TFPD 149 Staphylococcus au... 19112759 375 DLVSALVEDA-EARQLLLDddhLLRSIPDIPKLCRRLTRGSASLEDVVRIYQMAKALPKIVTVLDSLTSEH------KDL 447 fission yeast 19112758 -------------------------------------------------------------------------------- fission yeast 13541505 34 DGITSGYTDY-NLRPFFI----TMPRSLDTVKYRQEIFKDLLNSEVFALMKDFSEKMNTIYKWVSTADRLG-----GYQK 103 Thermoplasma volc... 13541506 36 NVMAGKDTYV--FDVCRRt---ILNSVNDKSTIIYRQDVLKDAIRNQNIIRKIYSTIVTAESEAKRSYFWIs----RSNP 106 Thermoplasma volc... 14318519 324 EALEELKAND-DLLQKLRl---EMKSLPDLDKLFSRLLCINHSAIKPDQRINYVLLLKETLQSVKSLKDALn---dQLIQ 396 baker's yeast 2506880 373 DLVDYLIDQI-ELRQMLTSe--YLPMIPDIRRLTKKLN-KRGNLEDVLKIYQFSKRIPEIVQVFTSFLEDDsptepVNEL 448 baker's yeast
19075844 797 LLGEIIqSAPN----MKEELEAWTRAFNWQKASEEGv--------FEPEIGFEAEYDTSQKYQSe-LKNELYALLEQYkK 863 fission yeast 15896285 220 VVS---------------IVVSIVIIYMKLKAYYWV----------IAALFVLHMLINIMGYLK--VAPQLRIIYKIR-K 271 Clostridium aceto... 15896798 182 IWKDIEvDYKY------KYVFNFLFWGTLASILTIP----------ILKYGYIILLAAFILMNTi-EHNKFKNKVELY-- 242 Clostridium aceto... 15927623 150 QITPVK-----------RQNILFLCPFLPVISFAVI----------FINSQVGILLFLMSCLFN--IILSATLKRTYEdD 206 Staphylococcus au... 19112759 448 VDKVYTnVLNNhcknLEKLIELVETTIDLEALDSHQ---------YIIRAEFDEELLDLRQRLD--ELQHSIFEEHKR-V 515 fission yeast 19112758 1 --------------------------------------------------------------------LRGRSSHYTElS 12 fission yeast 13541505 104 QGWLLEaALFY-------FNTMADFSLKLDNLDFKSq-------gLLMLREYLRELVHTDAFIVa-SREANTVKSLLSaI 168 Thermoplasma volc... 13541506 107 EFALHEsISIL------KIYLTAIENIRDVGREALP---------LLHSNGLKQLFTMIMQEFNheYVAEVLNHLEILrF 171 Thermoplasma volc... 14318519 397 SRLISEtKKIFnndaIMEIEKLINSCINEDCVWASSaiqllnqrsYAVKSDSNGLLDVSRQIYKe-VKEEFFREVEDLtA 475 baker's yeast 2506880 449 VRSVWLaPLSHhvepLSKFEEMVETTVDLDAYEENNe--------FMIKVEFNEELGKIRSKLD--TLRDEIHSIHLD-S 517 baker's yeast
19075844 864 QLRCSSLN---FKNIGKEVYQ---VEVPSDVKVPVNW-------CKMSGTKKTNRYYNDELRKKIKKLLEAEELHLAIMS 930 fission yeast 15896285 272 DLKSYFRIl--DIIENEDFKSd-yLKELKSVLYFENK-------PAYRIFKSLISITEKLEFKNNIFGYVIFGIIMLWDY 341 Clostridium aceto... 15896798 243 VQSLGYLN---GIINTANRIS---KINCPEIKYYTDSlk----aTSSKLMKVAKKTAGIERVEGVDIIGDALYNILPIEE 312 Clostridium aceto... 15927623 207 LKSIFYAS---NVLKQG--YT---ISKIKHAPQPEVNf-----kQFRTARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDY 273 Staphylococcus au... 19112759 516 GSDLHQDTekkLHLEQHHLYGw--CLRLTRTEAGCLRgrs-shyTELSTQKNGVYFTTKRLHSLNNSYMD---------- 582 fission yeast 19112758 13 TQKNGVYF---TTKRLHSLNNs-yMDHQKSYRYHQNGl------AREVIKIAATYGPPLEAIGQVIAHLDVILSFAHAST 82 fission yeast 13541505 169 RYEMLIES---SKVTIRRDKGkddYNEIVKKLFDKFT-------NRNATSKSLKRFYETSMNQVEAAVLELIARLFPEEF 238 Thermoplasma volc... 13541506 172 HNGISVRG---SLGFANSLIGy--NLLMPDAKSNKILd-----kISLIRERHYTYVLPDRDEIGAQELADMRAKSIRETA 241 Thermoplasma volc... 14318519 476 KNKINLDH------NYDSARGf--YLRIKRQEFTDDVatlpdvfISRTIKKNYIECTTLNIIKKNARLKEVMEEILLLSE 547 baker's yeast 2506880 518 AEDLGFDPdkkLKLENHHLHGw--CMRLTRNDAKELRkhk--kyIELSTVKAGIFFSTKQLKSIANETNILQKEYDKQQS 593 baker's yeast
19075844 931 RMQEKFYIRFDSNYEQWLA-LIKYTASIDCFFSLSQAAaaLGEPYCRPEIIEQKDg-hLYFEELRHPCINASAAST--FV 1006 fission yeast 15896285 342 QCVFEFERWKDRYGKIVSK-WVDAIGEFESLSSLSVIFr-LNSHMVFPELSESGLv--FSGKEVGHPLIGEEKR-----V 412 Clostridium aceto... 15896798 313 RKFFNSINDIRKLRKELKE-LYKALGEIDALMSIASFRq-WIQYYCEPEFVDNGRi--IKCSEIYHPLLENPVS------ 382 Clostridium aceto... 15927623 274 VLFHSIQKSYTTHMNELKN-CFDYIAELDNHYALAMYRr-TLECYTEPQIDDTNDg--IVFSELTHPLIADAVA------ 343 Staphylococcus au... 19112759 -------------------------------------------------------------------------------- fission yeast 19112758 83 VAVIPYVRPNIVDSSIAQE-KHGQSSNILDIVSLEDTP--NFEEIRRTLENNHCAr--LYLKQARHPCLEAQDDVK--FI 155 fission yeast 13541505 239 KALSSFYENHKNFIDPTTAqMYRELQFYLSYIEYISPLekTGLKFCIPEVGTVRDi--YCIECFDLALAQRLLQSGsvVI 316 Thermoplasma volc... 13541506 242 AILTESAQNVLAFIDRIKEgVAFYLGCLNLLDELTKIG--APISFPVPENNENNG---MYYTGIYDVALCLRTKTVp--V 314 Thermoplasma volc... 14318519 548 ETVDELLDKIATHISELFM-IAEAVAILDLVCSFTYNL--KENNYTIPIFTNN-----LLIRDSRHPLLEKVLKN---FV 616 baker's yeast 2506880 594 ALVREIINITLTYTPVFEK-LSLVLAHLDVIASFAHTSsyAPIPYIRPKLHPMDSerrTHLISSRHPVLEMQDDIS--FI 670 baker's yeast
19075844 1007 PNDVVLGGeSPNMIVLTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASITPMTSIYTRLGANDDIMSARSTFMVELSE 1086 fission yeast 15896285 413 NNDVDMNN---KIFVITGANMAGKTTFLRTVGINLVLAYAGAPVCASNLKCSVVD-IYTSMRITDDLNNGMSTFYVELMR 488 Clostridium aceto... 15896798 383 -NSIDLDG---KGIMLTGTNMAGKSTFLRTIGLNSLLAQT-IYTCAAKVYKTSFFKIMTSISPEDNISSGKSYYFREAEA 457 Clostridium aceto... 15927623 344 -NDFSLSQn----ILLTGSNASGKSTFMKSIAINIILASAIQTVTASKFVYQPGI-VFTSMANADDVLSGDSYFMAELKS 417 Staphylococcus au... 19112759 -------------------------------------------------------------------------------- fission yeast 19112758 156 PNDVNLEHgSSELLIITGPNMGGKSTYIRQVGVITVMAQIGCPVPCEVADLDIIDAILARVGASDSQLKGISTFMAEMLE 235 fission yeast 13541505 317 ANDFRLSR-NENIIVVTGPNSGGKTTFARSIGQVFFLAMLGLPIPGSKAKLFQVDNIYTHFEKSEDLENLRGKLEDDLIR 395 Thermoplasma volc... 13541506 315 RNSLSAEH--DSIIFITGANRGGKSTLLRAIGQAQLMMQCGMFVAAESFSAYIASGIFTHFKREEDSGMSMGKLEEEMNR 392 Thermoplasma volc... 14318519 617 PNTISSTKhSSSLQIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGSFPVFKRLHARVCN-DSMELTSSNFGFEMKE 695 baker's yeast 2506880 671 SNDVTLESgKGDFLIITGPNMGGKSTYIRQVGVISLMAQIGCFVPCEEAEIAIVDAILCRVGAGDSQLKGVSTFMVEILE 750 baker's yeast
19075844 1087 TKKILDECGPKS--LVILDELGRGTSTYDGHAIAYAVLHHLVSNIGCLGFFSTHYqSLCVDFMHH--RQVRLMQMAa--- 1159 fission yeast 15896285 489 VKKMIENVKKKTpmIFLIDEIFHGTNSNDRIAGAKKVLKILNEN-WIFGLISTHD-FELCELESDekRRIKNYHFS---- 562 Clostridium aceto... 15896798 458 LKRIINQCSDDRpvLCIIDEIFRGTNPIERVNASAEILNYIEKH-NTLTLVATHD-LELTEILKEd-YLCCYFSED---- 530 Clostridium aceto... 15927623 418 IKRIVEIPDNQKi-YCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHD-IELAELLKQr---YENYHFN---- 488 Staphylococcus au... 19112759 -------------------------------------------------------------------------------- fission yeast 19112758 236 TATILRAATPRS--LIIIDELGRGTSTTDGFGLAWAITEHIVTQIGCFCLFATHY-HEMTKLSEEi-TTVKNLHVT---- 307 fission yeast 13541505 396 MRKILDSATERS--LIIINEMLSSTASKDAISIGTKIIDLINKK-NSICVYVTFF-EELARIRGV----IS--MVS---- 461 Thermoplasma volc... 13541506 393 MSLIIDHIKAGG--RLFLNESFSSTNVREGSEIAKQVINALLDS-GVKVIFVTHF-NELAESYLGs-VYNPTFLRA---- 463 Thermoplasma volc... 14318519 696 MAYFLDDINTET--LLILDELGRGSSIADGFCVSLAVTEHLLR-TEATVFLSTHF-QDIPKIMSKk-PAVSHLHMD---- 766 baker's yeast 2506880 751 TASILKNASKNS--LIIVDELGRGTSTYDGFGLAWAIAEHIASKIGCFALFATHF-HELTELSEKl-PNVKNMHVVahie 826 baker's yeast
19075844 1160 --AVDEKIRr--VTFLYKLEDGICPKSYGMNVASMAGLPEKVIDAAEEKASELEQAS-----------ASFIN------- 1217 fission yeast 15896285 563 --ETYLEDK---IIFDYKLKDGPSDTTNAKYLMKMIGINVE--------------------------------------- 598 Clostridium aceto... 15896798 531 --IDDEGLQ-----FDYKLKYGICKTRNAVKLLKYLEYPNEIIQKTNDRLAKIL-------------------------- 577 Clostridium aceto... 15927623 489 --EVIENNN---IHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG--------------------------- 536 Staphylococcus au... 19112759 -------------------------------------------------------------------------------- fission yeast 19112758 308 --AYVGDSEskdVALLYNVCEGASDRSFGIHVAKLAHFPPKIIEMASNKAAELEAEDsgaqgdtqevkSKKEGmaiv--- 382 fission yeast 13541505 462 --QVDPIAPe--IRTFRVVRSDPNGLAYATAIAERYGLTYKKIIERVRK------------------------------- 506 Thermoplasma volc... 13541506 464 --ERLDNGK----RTFKILQADPITTSFGYDIFLKVFGESAKT------------------------------------- 500 Thermoplasma volc... 14318519 767 --AVLLNDNs-vKMNYQLTQKSVAIENSGIRVVKKIFNPDIIAEAYNIHSLLKIAKAr----------TENEDsng---- 829 baker's yeast 2506880 827 knLKEQKHDdedITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRKANELDDLKtnned-lkkakLSLQEvnegnir 905 baker's yeast
19075844 1218 -----ASDDIALMSdf----lQVLRISKSIEPLTAVN----------IPLILDSFE 1254 fission yeast 15896285 -------------------------------------------------------- Clostridium acetobutylicum 15896798 -------------------------------------------------------- Clostridium acetobutylicum 15927623 -------------------------------------------------------- Staphylococcus aureus subsp. aureus N315 19112759 -------------------------------------------------------- fission yeast 19112758 383 -rdimRQWRSNVKPemt--qqQMMDQFQKVIGSFAQqi-------nsNNWLQSRVS 428 fission yeast 13541505 -------------------------------------------------------- Thermoplasma volcanium 13541506 -------------------------------------------------------- Thermoplasma volcanium 14318519 830 ---vvDQKTINQMKrih-nlvAILKECAGNEKEPLTLgkl----keiNSDFIENFE 877 baker's yeast 2506880 906 lkallKEWIRKVKEeglhdpsKITEEASQHKIQELLRaianepekenDNYLKYIKA 961 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",