732208 409 RELMhlppkqWLQFIMGQTSLLKFLLITSCFiaLLTFNLtpftqd------slqknCFAILIYASLLWATETI---PLFV 479 baker's yeast 15615946 16 MFVAlirewfVPELTVFFALSSLVLFNVLTPgeALNGFAntgvhtvallfviaaavSKSDVLHQLMKRVLHQTt-nLSTI 94 Bacillus halodurans 15791916 1 ---------------------------------MIMVFLii----------------sSIIVAIILGYITRHNv--GIFA 29 Campylobacter jejuni 15599034 15 TVALfihnrlRLDVIALLVIMAFSVSGTLTLneALAGFSdpsviliaalfvigeglVRTGVAYQVGDWLIARAgssEARL 94 Pseudomonas aerugin... 18313796 13 LAAVtlsfkyRADIIAFVSLMALVLVGVYDLreALSYLIspavivlfgsmvisgviADSGLLDRVARYISVRVr-hVATA 91 Pyrobaculum aerophilum 15603864 24 AIVLfvrnkiRMDVVALLVIVAFALSGILSVneVLAGFSdpnviliallfivgegiVRTGIAYQVSEWLLKASknnETKV 103 Pasteurella multocida 15901840 1 ---------------------------------MIHLIMi-----------------sAIALAIGIGYRTKINi--GLLA 28 Streptococcus pneum... 16765660 15 AVVLfatgkvRMDAVALFVIVAFVLSGTLTLpeAFSGFSdpnviliaalfiigdglVRTGVATVVGTWLVKMAgssEIKM 94 Salmonella typhimur... 15837387 21 TMAMfvweriRADVVALIVLVVLGTTGLIPPeeLFGGFSgnavmsiiatailgaglERTGALNRLAAWLLRRShgsERRL 100 Xylella fastidiosa ... 16122779 15 AIVLfttnklRMDVVALLVIIAFVMSGTLSLseATSGFSdpnviliaalfvigeglVRTGVAYQMGDWLVKVAghsETKM 94 Yersinia pestis
732208 480 TSLMIPLLIVVFPv------IKDpitsq----pmsprDSSQFILSTMWSSVIMLLLGGFTLAAALSKYNIAKVLS----- 544 baker's yeast 15615946 95 LCRLMIPISSLSAfmnntpiVTMliptvqqwaisnkiKPSKLLIPLSYAAILGGTITLIGTSGNLVIHGLMLDKG----- 169 Bacillus halodurans 15791916 30 MIFAYIIGAFFMD------------------------LAPKKIIAFWPISIFFVIFAVSLFYNFATVNGTLEKLA----- 80 Campylobacter jejuni 15599034 95 LVLLMLAVAGLGSvmsstgvVAIfipvvlsiaaklkiPPGRLMMPLAFAGLISGMMTLVATPPNMVVNSELAREG----- 169 Pseudomonas aerugin... 18313796 92 SLLLYFVAGVASGfvsdvaiVLAmavligdvakrlgaSPAAYVIPLAFAAAIGGRLTMVGNAGNVILLDIYQTTTge--- 168 Pyrobaculum aerophilum 15603864 104 LILLMLAVAVLGSfmsstgiVAIfipvvlvicqqmniSPKRLMMPLSVAGLISGMMTLIATAPNLVVNAELIRNT----- 178 Pasteurella multocida 15901840 29 IAFSYLIATTLMG------------------------LSPKELLHFWPTSLFFTIFSVSLFYNVATTNGTLDVLA----- 79 Streptococcus pneum... 16765660 95 LVLLMITVAGLGAfmsstgvVAIfipvvlsvsmhmqtSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLREG----- 169 Salmonella typhimur... 15837387 101 LLITLGVAGLNSPfmqntsvMALympvaarlaartglTLQRLLLPIAAMIVMGGALTMVGNSPLILLNDLLQSANnnlps 180 Xylella fastidiosa ... 16122779 95 LALLMVTVAGLGAfmsstgvVAIfipvvlsvasrmkiSPGRLMMPLSFAGLISGMMTLVATPPNMVVNSELVREG----- 169 Yersinia pestis
732208 545 ----THILASAGTNPHFILLTNMFVALFVS---MWVSNVA-----------------------APVLCYSIVQPLLRTLP 594 baker's yeast 15615946 170 ----LDGFSMFDFAYFGIPLTIVGILYMVLfghRFLPDREhhvae-------------lqdteRSYMFQFIVETSSPLIG 232 Bacillus halodurans 15791916 81 ----GHLMYRFANHPYLLPFVIFVVSAIIAa--LGAGFYT-----------------------VLAFMAPLTFLLCDKIG 131 Campylobacter jejuni 15599034 170 ----HAGFGFFAFTPIGLMVLAIGVAYMLLt--RNWLNAAspaevgapkarrtlrdlirdyrlAGRERRLQVQLGSPLIG 243 Pseudomonas aerugin... 18313796 169 ---kLNILAFTAPALLALAISVPLLLLISFyaqRFVPQLS-----------------------TAVKFLVVTTEVGETLD 222 Pyrobaculum aerophilum 15603864 179 ----DFRFHFFDFTPIGLVVLTMGILYMLVa--RHWLTDPeeqtkkdtsrr-smndlideyglRERTKRLVVKKGSPFIG 251 Pasteurella multocida 15901840 80 ----QHILYRTRTHPNALYMILYLMATLLSa--LGAGFFT-----------------------TMAVCCPLAITLCQKAD 130 Streptococcus pneum... 16765660 170 ----LHGFNFFSVTPLGVVVLALGIVYMLVm--RFMLKGDapgqqagkrrt--frdlireyrlTGRARRLAIRPGSPMVG 241 Salmonella typhimur... 15837387 181 giatIEPLRMFAPLPIGVALLIAALFYFFFygdRKLIQEEqlaneevaaar-hesyfartygiDADVFELVVNVGSPLVG 259 Xylella fastidiosa ... 16122779 170 ----IKGFGFFGVTPIGIIILFMGVAYMLVa--RRWLGGKqehtekdqwkrrtfrdlirdyklTGRARRLAIRHGSPLIG 243 Yersinia pestis
732208 595 RNCS-------------------------YAKALILGIALASNIGGM-----------SSPIASPQNIFSIGIMDP--S- 635 baker's yeast 15615946 233 KTIKegml------------------rnlDQLFLIQVIREGKRIVPApndelihpediLIFSGSADGLIQLKAIPGl-Sl 293 Bacillus halodurans 15791916 132 LSKIa------------------------gAMAINYGALGGANFITS-----------QSGIIFRGLMENSGIEAN---- 172 Campylobacter jejuni 15599034 244 STLEelqlrtrlganvvglervrkfhsevVKVGGSTELKAGDVLLLD-----------VFAPPEDMDRRCAELNLVrlPf 312 Pseudomonas aerugin... 18313796 223 GKTRq-----------------------eVEKAYRVKILTKDRILLKyst-----vlvKIAVSDIPSFMTSKDLILrpLg 274 Pyrobaculum aerophilum 15603864 252 KNLDelhlrssyglnvlaierwkrfrpmfIAALGTSEIREKDILMMD-----------SSHPEFDLEQFCQVNHLEmaEi 320 Pasteurella multocida 15901840 131 KHPLi------------------------GAQAVNWGASGGANLITS-----------SSGIVFQGLFKQMGWEEQaf-- 173 Streptococcus pneum... 16765660 242 QRLDdlklreryganvigverwrrfrrviVNVNGVSEFRARDVLLID-----------MSAAEVDLREFCAEQLLEpmVl 310 Salmonella typhimur... 15837387 260 MTVGeaetiqgap--------lllalktgNDTRLSPPVDMRIWVGSVf---------gAMGPRQQVADFAKNQLLNvsSr 322 Xylella fastidiosa ... 16122779 244 RSLDelhlraryganvvgierwrrfrrvmVSATGSSELRENDVLLID-----------MSDCDMDLREFCSEQMLEplVl 312 Yersinia pestis
732208 636 ---PSWAEWFMIALPVCFICVMAIWVLLIITFPPEP-------NVKILQLHPSRDPFTLKQWFVTLVCIITIVLW----- 700 baker's yeast 15615946 294 lsdGKQPSLPENHALVEVVVSSTSSLVSKKINETNFrekyeaaIVAVQRKHKKIRSRIGDVVIKPGDTLLLLTGKhflsr 373 Bacillus halodurans 15791916 173 ---EAFANSSIIFAFTIILPIVVLSFFVFNAFKNNIkisviskPDPFDYKQKTTLILMFMMIVVVLIFPVLNIIFp---- 245 Campylobacter jejuni 15599034 313 rasYFIDQ-SREVGMAEVTLPPDSTLLGKSVLELGFrsqyglnVVGLRRDHEALTDGMLEEKLRLGDTLLVIGAWkairq 391 Pseudomonas aerugin... 18313796 275 nnkGEHMEFLIVTQRSRLVGKTLALEPIHNVFPVSIigivpsgPVESLESYVFRPGDEILVLGDEKVIERIAAYYr---- 350 Pyrobaculum aerophilum 15603864 321 rsqSFSQQ-AKSIGMAEITLVPDSDCIGKTTSELRFrsqfglnVVGVKRDGEVLVGNFSDVSYALGDLILVVGDWkaiaq 399 Pasteurella multocida 15901840 174 --sLGNHIFIVSIIYPLIVLLLLSCYSHYSKGRT-NssltidqPPLLSKVQRQTTLLMISSMVLVWLFPLLHLIFp---- 246 Streptococcus pneum... 16765660 311 rgeYFSDQ-ALDVGMAEISLIPESELIGKSVREIAFrtryglnVVGLKRDGVALEGSLADEPLLMGDIILVVGNWklisl 389 Salmonella typhimur... 15837387 323 lrhLGDLFNPACAGICEVLIPPNSRFIDKTSTELRLrkqmgisLLAINRDKHVIREDVRNVPLRAGDMLVLHSLWqdlaq 402 Xylella fastidiosa ... 16122779 313 rgeYFSEQ-SRNVGMAEVSLIPDSALLGKNLREVAFrsryglnVVGIRRNGKTLEGKLVDDKLQFGDILLVIGDWklirq 391 Yersinia pestis
732208 701 ---CLSNQISGIf------------------------gEMGIISIIPIVVFFGTGLLTS---------DDFNNFMWTIVV 744 baker's yeast 15615946 374 wsdSDDFYVLSPikkiavrpayer---rivigvllmivLGSAFQLLSIFKLCLIGVAILifsnvltmaDVKKAINWNVII 450 Bacillus halodurans 15791916 246 ----HNETISYFn-------------------------KKIDIAMIAMIFVAIALFLKLad-----ekQVVALIPWGTLI 291 Campylobacter jejuni 15599034 392 lqgRNRDFLVLSlpaeidevapalskaphallslavmvALMVSGVVPNVVAALVGCLLMglfrcidmdGAYRAIHWQSLV 471 Pseudomonas aerugin... 18313796 351 --lERSKTLVKAfn-----------------------pRLAASGISGLFAAVVLSQFAP---------ASLAFIIGTFIA 396 Pyrobaculum aerophilum 15603864 400 mqhHAKDFYVLNyplemeravpaatqaphavfailtmvVLMVSGVVPNVIAALIACLMLgyfrcvdgkSAYESIHWSSLV 479 Pasteurella multocida 15901840 247 ---NIAWIATYQ--------------------------KTFDIGFVSILMVCLALRLKLgk-----qeAILAKVPWATII 292 Streptococcus pneum... 16765660 390 lgqKGRDFVVLNmpvevseaspahsqaphaifclvlmvALMLTDEIPNPIAAIIACLLMgkfrcidaeSAYKAIHWPSII 469 Salmonella typhimur... 15837387 403 aaeSRDFVPVTDypkgeqrphkf----kiamaifaftiLIALTAKLPVALTLLTGVACMlvtgvirmdEAYTAISWKTIF 478 Xylella fastidiosa ... 16122779 392 lqlKTRDFIVLNlpaevdevapaisqaphalfclalmvAMMLTDEVPNVIAALVACLLMgqfrcidmeSAYRSIHWPSLI 471 Yersinia pestis
732208 745 LAMGGTTLGKAVSSSGLLSTMAQLIKAQVEHEP---IFIIVLIFGLVILVMATFVSHTVAAM-IIVPLMSEIGSNLPSGD 820 baker's yeast 15615946 451 LMGSSIGIGTAVEKTGLAALLAGGISFVQTAVG---LAGILVMFFIVTLILTEIISNLATAA-FMFPIGYSISLQLQLDP 526 Bacillus halodurans 15791916 292 MICGVGMLISIAVEAGAIKLFSDLVENEIN------VIFIPLIMCAIAAFMSLFSSTLGVVTpALFPIVPSIAASSGLSE 365 Campylobacter jejuni 15599034 472 LIVGMLPFALALQKTDGIDLVVSLLVDALGDAG---PRVLLASLFLLTAAIGLFISNTATAV-LMAPIAIATAKQIGASP 547 Pseudomonas aerugin... 18313796 397 LLGGGKAVERLYQYVSWETLIYVGSFLAIGTAAariDLLKPITPLLNSPEYLFVIGLFLTNTlGLIPSAVLIGPYLTTKE 476 Pyrobaculum aerophilum 15603864 480 LIVGMMPFSIALQKTGGVDLAVKLMLDAVGGLG---LHAVLMSLFLLCAAVSLFISNTATAI-LMAPIAITIAHQLQVSP 555 Pasteurella multocida 15901840 293 MLCGMSLLMSLAVKSGLVTLIGHLMTTTIP------HFWLPLFFCVIAGVMSLFSSTLSVVApALFPIIAIISAQNPQID 366 Streptococcus pneum... 16765660 470 LIVGMMPFALALQKTGGVSLVVQGLMDIGGGYG---PYMMLGCLFVLCAVIGLFISNTATAV-LMAPIALAAAKSMGVSP 545 Salmonella typhimur... 15837387 479 MMAGLIPLGWAMDSSGTAAWVAGHTIDRLPHGMp--IWAIELALALLTTAFSLVISHVGATI-VMVPIAVNVALAANGNP 555 Xylella fastidiosa ... 16122779 472 LIIGMMPFAQALQKTGGVDLIVRGLMDVAGGMG---PRVMLLCLFVLCATIGLFISNTATAV-LMAPIAIATAREMALSP 547 Yersinia pestis
732208 821 hsRLLIVIAALLCSSAMGLPTSGFPNVTAISMIDEVGDRYLTVGTFITRGVPASLLSYAAIVTVGYGI 888 baker's yeast 15615946 527 --SMLAMVTAIAASCSFLSPIGYQTNLLVYGPGGYKFTDYVKVGLPLTILCMIVTIGLSMYKWLM--- 589 Bacillus halodurans 15791916 366 --ALLFSCIVVGAQASAISPFSSGGS-LILGSCPDKYKEKLFKDLLIKAVPIGFIAAILATIIMSFIL 430 Campylobacter jejuni 15599034 548 --YPFAMVVAVAASAAFMTPISSPVNTLVLGPGQYRFGDFVRIGVPFTLLVMFVCVLVIPWLFPL--- 610 Pseudomonas aeruginosa PA01 18313796 477 ---MLMT--YVLATIPILLPPAHPAIYLIYREYGLSIKDFLKISIPATAIAILATGIAVYLYYNLPIQ 539 Pyrobaculum aerophilum 15603864 556 --MPFAMIIAVAASAAFMTPVSSPVNTMVLGPGGYKFADFVKVGVPFTLLVMIVSVFLIPLLFPF--- 618 Pasteurella multocida 15901840 367 i-HLLTTATVIGALSTNISPFSSAGSLIQLSLPNIEERGLAFKKQIILGVPISLSLGLLTTWILILLA 433 Streptococcus pneumoniae TIGR4 16765660 546 --YPFAMAVAMAASAAFMTPVSSPVNTLVLGPGNYSFSDFVKLGVPFTLIVMAVCIVMIPMLFPF--- 608 Salmonella typhimurium LT2 15837387 556 ---TAFGLIVALAASNNLMTVSNPVISMVTGPANYQPRELWKVGGPLSLIYIVVMVVMINLMSQWGVL 620 Xylella fastidiosa 9a5c 16122779 548 --YPFAMIIGIAASAAFMTPVSSPVNTLVLGPGGYKFGDFVRMGVPFTVLVMIVSVMVVPLLFPF--- 610 Yersinia pestis
Jiyao W et al.(2023). "The conserved domain database in 2023.",