Conserved Protein Domain Family
ARA1

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COG0656: ARA1 
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
Statistics
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PSSM-Id: 223729
View PSSM: COG0656
Aligned: 94 rows
Threshold Bit Score: 86.9253
Threshold Setting Gi: 13541706
Created: 7-Oct-2002
Updated: 23-Jan-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586553    20 TTEIYFSLNNGVR---IPALGLGTANPHEKLAe-----------TKQAVKAAIKA-GYRHIDTAWAYE---TEPFVGEAI 81
gi 16263625  15 ASRTPIRRPIPKSgemIPAIGLGTFETFDILPgep-------rdDLRDVIRLFHEnGGRVIDTSPLYGt--AEVCVGDFI 85
gi 16265111  14 ADLTKRVIPKSEEp--LPLIGLGTWITFNVGDdpv------lmdECAAVIAAFFEgGGRMIDSSPMYGs--SQPTIGYGL 83
gi 15899596   1 --MEKKPLGWTNEk--ISPLILGSWEFGTPSIide-------nnAIKAIQRAIEL-GINAIDTAESYGnglSETIIGRAI 68
gi 13541706     --------------------------------------------------------------------------------
gi 13541983   7 EMEYKEFGNTGVK---VSSVGIGTYYDPGWMAlsrfnvkrdaekKIQAIRTAIDA-GVTLIDTAEIYG---SEDLVAKAI 79
gi 16081208   3 GMQTAEFDGTGRK---VSVIGVGTWSlegs-----------rseNVRSIRYALDH-GVNFIDTAEMYG---TEDIVGEAI 64
gi 16081541  12 RMEFREFGKTGEK---ISKIGVGTYYDVGWMFlarfgrksgsemKIRAIRTAVEN-GVTLIDTAEVYG---SEDLVARAI 84
gi 15789702   3 MAQDTQQRAAVVEe--MPEFGLGTWENEDPSa------------CADSVRTALEM-GYRHIDTAQIYE---NEDAVGDGI 64
gi 15790128 300 apsgfqpggraLR---LPPVGFGCSRYRDGTY------------VTPAMGAAVDA-GYRLFDTAELYG---NEWRLGDLV 360
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586553    82 KElledGSIKREDLFITTKVWPVL-----WDEVDRSLNESLKALGLEYVDLLLQHWPLCFekiKDPKgisglvktpvdd- 155
gi 16263625  86 MDl-----gIADDIFITNKTWTTGdylsdNSHSERQLRQSRERLWRERIDVLQVHSLEN--------------------- 139
gi 16265111  84 GK----LGYP-KQLFSAEKVWISDp-----gEGAAQIEASKDYWGVRKFDLMQVHNLVS--------------------- 132
gi 15899596  69 SK------FKREDLFIITKVSIDHl---rYDDVLKASEGSLKRLNTSYIDLYLVHWPN-----HYVP------------- 121
gi 13541706   1 ---------------------------------MKAREASLNKLGIDYLDLYQFNWP-------NPDv------------ 28
gi 13541983  80 EGh---nR---EELFIATKVWINHl---rYDKVIKACKASLSRLNTKYVDLYQIHFP-------SPTa------------ 131
gi 16081208  65 KGy---rR---EDLFIATKVWPTHf---aYHDVLKSCEESLKKLGTDYVDLYQLHWP-------NPSv------------ 116
gi 16081541  85 EGv---dR---ESLFIATKVWITHl---sYDSAIKACKRSLKRLNMKYIDLYQIHFP-------SPIg------------ 136
gi 15789702  65 AA----ADVDREDVFLATKVWTSEl---gDGDVAPATEQSLEKLGVDYVDLLYVHWPANq---YDAT------------- 121
gi 15790128 361 AAp---GGPDRESVFLVGKPWRTNh---gPGDLREACTGSLDELGVAAFDCYALHWPGAWahrGALTrlserpveeqerl 434
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586553   156 -----sgktmyaadgdYLETYKQLEKIYLDPndhRVRAIGVSNFSIEYLERLIKE-CRVKPTVNQVETHPHLPQME---L 226
gi 16263625 140 ----------------HDQVRHWLAHKKAEG---SIRYIGITQWSPEYYDTMERLvNTGTLDFVQIAYTIVTRAAEq-rL 199
gi 16265111 133 ----------------WEEHLPALFDMKAAG---RLRYVGITTSEGRRHREIEQImVSQPIDFVQVTYNILDREVEe-rI 192
gi 15899596 122 ----------------IRETAKAMERLFNEG---KIRYVGLSNFSLPLMREFREHlSKTDVAANELHYNVLFRDVEk-eV 181
gi 13541706  29 ---------------lIGETMKATEELMDEG---KIKNIGINNFSAK--------------------------------- 57
gi 13541983 132 ---------------nLQETFKAMEKLVDDG---LVKFIGVSNFSRGKLEKSMEYvKKYEIVSNQIHYSLKKRDAEe-dI 192
gi 16081208 117 ---------------sIKETMSAMEKLVDEG---RIRYIGISNFSVKEMKEAMSAlAKYRIVSNQLEYNVATREIEdegI 178
gi 16081541 137 ---------------dIEGTLRAMEKLVDDG---LIRYIGVSNFNLDQLKHAMEAmKKYEIVSNQVHYSLRHRDPEt-dM 197
gi 15789702 122 ------------------ETLAALADLQADG---VTERIGVSNFEPRHLDEAEDV-LGELPFANQVEFHPLLQQEE---L 176
gi 15790128 435 tmptaadgtparaphgLVETWRRMEALHDDG---LARSLGVCNVTLPQLAGLTDA-ARVRPALVQVECHPYRPRDA---L 507
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586553   227 RKFCFMHDILLTAYSPLGSh----------GAP---NLKIP----------LVKKLAEKYNV-TGNDLLISYHIRQG--T 280
gi 16263625 200 LDACSANGVAVQVNTPFEK-----------ARLftpVAGQP----------VPDFARELGVE-TWAQYFLKWIISHPavT 257
gi 16265111 193 LPLAQEKGIAVIVNRPFRQ-----------GDLirqIEDEP----------LPDWIAETGAR-SWAQFLLKFIISHPavT 250
gi 15899596 182 LPYMLRENIPLLAYDALGLgyligrkevrnEYRwyvLARETyiknleplieEISSIAKELGK-TPAQVVLNWLVSKDn-V 259
gi 13541706     --------------------------------------------------------------------------------
gi 13541983 193 VKFCENNGMAVLAWYPLEHg----------SLVresDYPSE----------ILARIKAKHPSiTPAQIALSYLIYGNklV 252
gi 16081208 179 YDFCRKNGMAIIAYSPLSHg----------KIFg-nEMILE----------TLTDIGKKY-GkRPAQVALNWIIRk--gA 234
gi 16081541 198 IPFAEKNGMAILAWYPLEHg----------DLVrdeAYPTA----------FLSDLRKRYPEmRASQIALSYLMEANsnV 257
gi 15789702 177 REYADGEDIELVAYSPLARg---------------eVFDVP----------EIQAVAEKHGV-SEAQVSLAWVRRKG--V 228
gi 15790128 508 VSWCHRHGVRVVAHSPLS------------APG---LLDEP----------VVHAVADEHGV-SPATAVLAWHCTRG--V 559
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 586553   281 IVIPRSLNPVRISSSIEFAS---LTKDELQELNDFGEKYPVrf------idEpFAAILPEFTGN 335
gi 16263625 258 NVIPATSQPEHVVDNMGALYgdlPDQAMRKRMTDHYTGLTGvadalkqppyPgKQYGGVVKWPF 321
gi 16265111 251 CAIPATTRVDHVRENLEAARg-iLPDEKLRGRMAAYVEAL------------------------ 289
gi 15899596 260 FAIFNTTKEDHLKENLGSLGw-sLRDSDLRRLDEAVKKVTId---------YfAR--------- 304
gi 13541706     ----------------------------------------------------------------
gi 13541983 253 FPIPRASNPEHVKENIASVEq-kLDQEEIEELRKYFN--------------------------- 288
gi 16081208 235 FPIPKASKPIHMAENIESTDf-tLSDEDMKTLDSLYQRHPIr---------SiASRYKGH---- 284
gi 16081541 258 FPIPRASNPDHVLENINSVKy-hLSEGEIKILKDSFRSL------------------------- 295
gi 15789702 229 TAIPKATGEDHIADNWASLDl-eLDDEDVAKIDGIDRRE---------------RQVDPEFGPW 276
gi 15790128 560 VPIPSTTTREHVVANLAAPRh-sLTDDQRDRMAGLADPTFQr---------------------- 600
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