17228422 472 EELFSITGsQEavpifs---------------qadvpkVEANvNVEQGwlaplenasldtkpwlvggvvgvfsalvvatv 536 Nostoc sp. PCC 7120 15594941 148 SILHNSLAkINnnfyipiaykitdskksnvgyiilyadISEKiAELKEylllllenslleq---------nastenssky 218 Lyme disease spiro... 15594942 151 SNSNFSSLgLKdvrldpiysvpveknskyysrymqidgKIYSiISFPVrdsvstlgvigi----------licfdesldi 220 Lyme disease spiro... 15893672 -------------------------------------------------------------------------------- Clostridium acetob... 15894028 -------------------------------------------------------------------------------- Clostridium acetob... 15894879 -------------------------------------------------------------------------------- Clostridium acetob... 15896781 -------------------------------------------------------------------------------- Clostridium acetob... 15639479 300 ITFSIPVYdEDrrviavlvadviwtwlcditgdfsvggVGRIaVIDEVgtvvahprhe--------------vvaqqtny 365 Treponema pallidum 15639626 143 SCFVPFVSiLArspf-------------------etgpQMAVyVMLSAggcl--------------------------lf 177 Treponema pallidum 15639627 121 LLLSYYLSsVGaal----------------------clIPFFhHPFFYtl------------------------------ 148 Treponema pallidum
17228422 537 sfTATNIAPPqqresl---------rytswaMSLAAGMTGFAAAAFMGSVTIKQVRRTTKDLQAqfda------vrqGSL 601 Nostoc sp. PCC 7120 15594941 219 fnVYIINSSGdafggkdeilknikhifgfnpKTLTEILNTLSQGKANYNTSNSNEIISLARITTsnw--------ylGIK 290 Lyme disease spiro... 15594942 221 ieNQLYSSLKfgsknynffmldrnympifsnLNNLQAKSFSTAYSENFLSKVIAYAKKDSSSSQytfnyerdfyslnFVK 300 Lyme disease spiro... 15893672 -------------------------------------------------------------------------------- Clostridium acetob... 15894028 -------------------------------------------------------------------------------- Clostridium acetob... 15894879 -------------------------------------------------------------------------------- Clostridium acetob... 15896781 -------------------------------------------------------------------------------- Clostridium acetob... 15639479 366 irLAKEDPATyasvaefvekviksdstashvFSYEGLEKIGSSAKMKSTGWTVVVFVPVSEFMGp------------VYT 433 Treponema pallidum 15639626 178 apALHFLLTRplerwaaflplressvranwtRMLLTIAIALFVATLLLVSAPLLVRTDSQNITP-------------AEL 244 Treponema pallidum 15639627 149 qeWAHFIPLRetrl-------------gyysLSREISVVLVSGLFSMFCVGFSSLLLPLHGEQE-------------LAH 202 Treponema pallidum
17228422 602 NVqatvysndelgqlsagfnemarviftTTNEAQRKADEQEEAKENLQRQVIRLLDDVEG--AA--RGDLTVQAEVt--- 674 Nostoc sp. PCC 7120 15594941 291 IDynnifske----------fknmrlvsLSIIFILVIIFILIMISTIKTLIISKIDKLNVviPKvkNGDLTFKIEsk--- 357 Lyme disease spiro... 15594942 301 TDdfltq-----------------glilNVNSIPIMFKSNWVIFVAFLLLSFAIIFYLCNtfVFslINDFNRIVDYqksk 363 Lyme disease spiro... 15893672 1 ---------------------------mKKRGEFIMENSNEVILNLMKTIAENMPVVFDNkaCIl-VTDKEKYIKvv--- 49 Clostridium acetob... 15894028 1 ---------------------------mEKDIMQSFKDVLPVLSELIQEDVATTIVNKDK--IAv-AVYHNNKIPis--- 47 Clostridium acetob... 15894879 1 --------------------------------MINQNVSPEKLAEAFSIVMPYLEVFFDKelAVa-VADKEKYIDvf--- 44 Clostridium acetob... 15896781 1 ----------------------------MEKIFESLIDAAPTIAEAFGGRAAVTIWDRDKcvYAl-DSNKKal------- 44 Clostridium acetob... 15639479 434 LQnyl--------------------lavGIIVVLFSLIVVYAVARKIVRPLRSTVRVLED--IAygEGDLTVRLPvv--- 488 Treponema pallidum 15639626 245 LTmag---------------------tfGLCASAVSCMEFLLCAYLTSREITRLRVLAEC--IG--TGDYTCADVPre-- 297 Treponema pallidum 15639627 203 VVit-----------------------hNLPCASLICVLSVIVMIRIGRHLDLANQGILTfiQNrlSGDASAASMRvv-- 257 Treponema pallidum
17228422 675 -----ADVLGAVA--DAFNLTIQN----LRDIVQQVKVAAKEVTK--------------GATNSETFARALSSDALRQ-- 727 Nostoc sp. PCC 7120 15594941 358 ----gKDSISSTIn--LFGHFIEN----LKNVINSLQERVKLLKEngdhlfseinkthnTIKNSNQYIEKTQEEVEKQve 427 Lyme disease spiro... 15594942 364 sdpfsLESPLEVKysSSIISYISSkldnLSSKSNESFEKIKFYSEdlneyleqietaisNTESIDSSILVYEQLRDTFsr 443 Lyme disease spiro... 15893672 50 ----kSSGLSLNV--NEGEPITND----LKQIINSGTPTTKDINE--------------SSLKIPIRRYTLPIKNGHGef 105 Clostridium acetob... 15894028 48 ---fnTGDLVPND--NPLCIAMEK----NRVISAVVPKEVYGVS----------------FKAIAYPINDSNGRVVG--- 99 Clostridium acetob... 15894879 45 ----cTDKMP-IR--TNANESIPK----GGAVYDSLNSGENIIKKv-------------PKEVYGIYFKSYAIPIKDE-- 98 Clostridium acetob... 15896781 45 ----aAKAGDKFD--VDFIKNVG-----AYDIVFNKKKTYTTIFNr-------------EEHGEDLRVTMIPAINENKe- 99 Clostridium acetob... 15639479 489 ----gGDEVSLLC--QYFNQTMEK----IRFAIATVGSSSDDMRRigdelasnmtetasAVNEITANIDGVKHRVDLQvs 558 Treponema pallidum 15639626 298 ----tRTSIGLLA--RSLSSLRDKdrafFSRFLQLTQSSSAIAHTaetdiahleeaartTKEEIDHVNENVTAQTATIss 371 Treponema pallidum 15639627 258 ----rRNEFGFLT--QSLNKMHKS----TRFFLIASRGKMARARKiansfvrnartscaAINEIISQAHKAEDKIKHQsr 327 Treponema pallidum
17228422 728 -----AEELGVTLNSVQVMTDSIQ-------RVA---EAAREAEK----VARDASTIALKGGEAVENTVAGILEIRETVA 788 Nostoc sp. PCC 7120 15594941 428 fisntTNIIESLSKNISSLDNSIEtq---aaSVEqssSAIEEMIG----GIQSITEITQKAAKSTEELKRFSDDGRKKQE 500 Lyme disease spiro... 15594942 444 ----fEKSIVDILKGFESIADPINdhnkyisEISsnfEESVSFFYsidkNLEIFNKVATINSTDIENIKSKVFDLNIVFE 519 Lyme disease spiro... 15893672 106 ---igSISISKSIDAKNKLLDLSS-------DLA---DTISNVSA----AVEESTANIQTLSENNKDILVNVHKAI---- 164 Clostridium acetob... 15894028 100 -----AIGVGKSLENKIKIEGIAE-------NLF---SSLSQING----AIDEIAQGSQRLSSVIVDVLSEANVTN---- 156 Clostridium acetob... 15894879 99 -----SGEVKGIVVGGKSLEKSIKl-----yDLS---KNIAEGMS----QIASVIENLTLGVQELVRLNENTNNIVN--- 158 Clostridium acetob... 15896781 100 -----VVGLVSVSMDLENAVSVKNst----lELK---SSLEQTNL----TISEITNSAVLLSEKLNRIIENTDVTK---- 159 Clostridium acetob... 15639479 559 gvseaTDTVERIIKTIKGLNSSIEtq---avNVAqssSSVEQMVA----NIVSITQTLERSDEAVHSLAIATADGRDTLV 631 Treponema pallidum 15639626 372 ----sKEIVGTMVEGVGRLNASVEae---seTVTrsiTLVEQMVE----KIHSIEKIIESNDARVGRLREETNRAGNLTN 440 Treponema pallidum 15639627 328 tifetQKHVQHIVGNIDRFNGHIG-------EQVdtvTDAASSVEqmvrNIESVTQVLSDNSNVIETLLLEAKLAQDATI 400 Treponema pallidum
17228422 789 EttrKVKRLAESSQEISKIVALISQIASRTNLLALNASIEAARAGEAGRGFAIVADEVRQLADKSAKSLKEIEQIVMQIQ 868 Nostoc sp. PCC 7120 15594941 501 EvitQIKEIFKNSTRLQEANSLISSIASQTNLLSMNAAIEASHAGEAGKGFAIVAEEIKDLAEQVTSQSESVASSINEIM 580 Lyme disease spiro... 15594942 520 NvnkNFADLLSQTNSLQSVNKLLVSISAQTNMLAMNAAIEAAKAGDAGKSFAVVAEEIRKLAINSGKYSKTIKDELKTVD 599 Lyme disease spiro... 15893672 165 ----------EHTKNSGSVLKFVQGVAKETNLLGINAAIEAARAGEAGKGFSVVAQHIRKLSNSTSDSIKEINEVL---- 230 Clostridium acetob... 15894028 157 ----------NKINETDSTIGAIKNIASQSNLLALNAAIEAARAGESGKGFSVVAQEMRKLSQNSSESAKKVSEML---- 222 Clostridium acetob... 15894879 159 -------SAIETTRNTDDILGFVQSISKQTNLLGINAAIESARAGEIGKGFSVVAQEIRKLSNSSSESIGKVDSVL---- 227 Clostridium acetob... 15896781 160 ----------KLIGESNEAVALIGSIAKQSNLLGLNAAIESSKAGEFGKGFSVVAGEMRKLASNSGESSRRILSAL---- 225 Clostridium acetob... 15639479 632 SssgITQKISEESGSLLEASSVIQHIASQTNLLAMNAAIEAAHAGEAGKGFAVVADEIRKLAEESSTQGKTITETLKTLS 711 Treponema pallidum 15639626 441 RsleLTQNISKSSKALLQASLVIRKIASQTTLLAMNAAIEAAHAGQDGRGFAVVADEIRKLAEESNEQGKIISSVLVQLT 520 Treponema pallidum 15639627 401 QsadVGREVLHASEALAEAGAVIQHIASQTNLLAMNASIEATYCKESGQGFEVVASEIRRLAEDASKQGKHISAVLRDVK 480 Treponema pallidum
17228422 869 SETGSVMTAM-------EEGTQQVIKGTK--------LAEEAKRS-------LENIIQVANRIDILVRS---IT---SDT 920 Nostoc sp. PCC 7120 15594941 581 DSITKTVNTSel----tNKAFNQIFDSIN--------LVVQVIEEin---htMQEQSIGSQEILKALNTmreIT---YEV 642 Lyme disease spiro... 15594942 600 SIIAVINSEIdtiyknfIDIQDNVDNNFSrh-----eKVDLTLAKh------FKEIGEFKERYLSHDTK---IRdakNMY 665 Lyme disease spiro... 15893672 231 ---------------------------------------KNIEES-------VQQIADKIRNSNESFDT---QA---AAL 258 Clostridium acetob... 15894028 223 ---------------------------------------LEMRNS-------IQSIISQINEVNVVAEG---HA---AAT 250 Clostridium acetob... 15894879 228 -----------------------------------------------------KEITKAINNIYDDTKN---TR---GAF 248 Clostridium acetob... 15896781 226 ---------------------------------------DQMSNN-------IKVIIDTINELGEIATN---QA---ASL 253 Clostridium acetob... 15639479 712 VEIDTLSTSS-------KAVEEQFDTIFR--------LSDQVRTMsrslteaMKEQSDGSREVLAAIKS---INaatVDV 773 Treponema pallidum 15639626 521 EKIEHIAQQAeslskqfSNLFVLAEEVKQ--------RESTVMHAmeeqssgGEYIRRSMEAITGNRRR---IRggiSLM 589 Treponema pallidum 15639627 481 TEIEKVSESAlavqaqfALIFSITTDIKAqeevisqsMVEQTKDSv-----hVLHAIQHITEITRTLQE---NS---GAI 549 Treponema pallidum
17228422 921 VEQT----ETSRAVAQVMQSVELTAQETS----QEAQRVSGAL--------QNLVGVS-------RDLISSVERFRV 974 Nostoc sp. PCC 7120 15594941 643 KIGSndmfRGNKEIISTIKLLGEINITVSnsmkGLKEEINTLVeaierikvLGTTNSSh-----iSGISESINQFKT 714 Lyme disease spirochete 15594942 666 KEIFnnhyFISGKFNNFSQDLKEFKVSKMn--lDAVSSLQEYS--------SLVKSSKdk----iLKTKELIQKIND 728 Lyme disease spirochete 15893672 259 EEIS----ASVQEVNNNAKTVEETARTL------------------------------------------------- 282 Clostridium acetobuty... 15894028 251 EEIN----ATIDEITTASQTLVEESKNI------------------------------------------------- 274 Clostridium acetobuty... 15894879 249 DEQV----SAFEQVNASIQELNSTSQILR----DLAENL-------------------------------------- 279 Clostridium acetobuty... 15896781 254 EEVS----ATVEQISANSQILVDNMDMN------------------------------------------------- 277 Clostridium acetobuty... 15639479 774 KEGSadmlKGGEVIAREMQRLDDLTSEIAr---SMNEMAAGAIein--navHEVNEITqrskqsiSSLADEVEKFKV 845 Treponema pallidum 15639626 590 LKDGelvlKDMNELAHNTGGITVAMHDMA----ASTSRILDAVts-----vKIIASENkn---amDMLTNQLTQLRL 654 Treponema pallidum 15639627 550 LDNSkhveEAMLALSRITSEIDSSVSSMH----KNSEQVKKYAss-----iTEIGQKNk------DSITDLVTELSN 611 Treponema pallidum
Jiyao W et al.(2023). "The conserved domain database in 2023.",