15639777 16 TRRRLLERFYAHPWVLVAVLSALTLFFAVQLRTLRLDNN-NFRFIPKENSVRIADQRIDSTFGsQVPVLIGIKREYTS-- 92 Treponema pallidum 15594597 1 --MDFEGLSIRYKGIIFTIFILITIFLGFFLKNLKFDAN--ILKLIPKTKETESLIDIDKSN--SLLSTIVIFQDKKN-- 72 Lyme disease spiroc... 15613283 1 -MTDIAAFIIKKRKTIVLSFAILTFISAIALFFVSVNYN-MTDYLPDEAQSTKAIEVLEEEFD-RTVSNARVMIRD---- 73 Bacillus halodurans 6226453 -------------------------------------------------------------------------------- Methanocaldococcus ... 20094492 1 ---------MRFRTAIILSFLALTAVMAYGALHLNVEVD--QTKYLPDRFESMKWQHVVERELgTSTKTLLIVIEADD-- 67 Methanopyrus kandle... 15598275 11 KASLLERLIFNNRPVVIFLCVLVSVFLFYQATQVRPSTS-FEKMIPLEHPFIQKMLEHRNDLAnLG-NTVRISVEAVNg- 87 Pseudomonas aerugin... 14521877 1 MLRKIARVIVIYRHSLAVVTMFLLILSAYGITQLRFETD-LSKQLPEDLEAVKSYFTLQNEFGgSGSALIYVKIKNNDnv 79 Pyrococcus abyssi 14590211 42 MLRKIARIIVVYRHSLAVITIFLLILSGYGITKLKFESD-LSKQLPEDLEAVKNYFTLQNEFGgSGSALIYVKIKSPDkv 120 Pyrococcus horikoshii 15643580 1 --MRRYLFTTTYVVLVFLSFFVVFSLGKIETGPEVFLPGyNGDPEKTTNENVKNLFRVNKEFG--GSSSIVIVVESDK-- 74 Thermotoga maritima 15644049 1 MFEKYTSFVFKNRKRIFALVLVINILALFGLFRLHFTTE-FSILMPQKSHQKEIYDRMNTIFK-SGEQLAVMVKMNTD-- 76 Thermotoga maritima
15639777 93 --VVDPVFLADVRSLIERISAVPLVRAEStl-slLSAEYLGLRAgn-iISErvVPDEFSGSAEEVQGvyrklrdwdfyeC 168 Treponema pallidum 15594597 73 --IFNKKNFETINSVISEITKILKVSPNAv---tSIFSYFPQFKke-iYTDkdIEEIKSKIKSTPFVk----------nT 136 Lyme disease spiroc... 15613283 74 ----VT--VQEALLYKKELEEIDGVSDVI------WLDEVIDL-----ETP--LEMADKDLVKSYYK------------- 121 Bacillus halodurans 6226453 -------------------------------------------------------------------------------- Methanocaldococcus ... 20094492 68 --VTRKPVLDYMRRIEDRLRSKPYVENVR-----GAPDVLRESPan-fPAAvtMPGLRPLMSEMERS------------- 126 Methanopyrus kandle... 15598275 88 -dIFTKEYMETLRQIHDEVFYIPGVDRSGlkslwSPSVRWTEVTeegfAGGevIPQTYDGSPRALEEl----------rN 156 Pseudomonas aerugin... 14521877 80 vdIRDPKIIEAMYSLEQRLREKEYVTDTF-----SIADLMVQI-----LGR--LPKNMDEVKFVLNMlpp------earN 141 Pyrococcus abyssi 14590211 121 adIRDPTVIKAMYSLEQRLKDKEYVTDTF-----SIADLAVQI-----LGR--LPNNIEEVKFVLNMlpe------darN 182 Pyrococcus horikoshii 15643580 75 ---NFFEDARTLYELHRALEEREDISSVM-----SPVNLPKLSG-----FRmdYYFKDEKISKDVLN------------- 128 Thermotoga maritima 15644049 77 --PLSREGLNKVFEIKERLSSIEGVKTVI-----TPVPEKFPVG-----FR--LVETKGMAEKEYED------------- 129 Thermotoga maritima
15639777 169 SLVSRDLRSMQIVVFLDTSNEESSSPEAMAACRAIIRILGAWKs---------------rDAQTFVTGVTVFNEMGNEAS 233 Treponema pallidum 15594597 137 FLGNSENLIYFIIIPSESDQINFSRNLKTELDEMEKTIKKYETd----------------DLKLYLTGDLIVREKILNYM 200 Lyme disease spiroc... 15613283 122 ----DESALFSLTIREG--DEVAVTDAIYELIGED----------------------------NALSGEAVNTAVSQQMT 167 Bacillus halodurans 6226453 -------------------------------------------------------------------------------- Methanocaldococcus ... 20094492 127 KEMFVSKDHKVAIIRVG-LKSDADYRKVVPDVRRSLERDKPKS-----------------VKFADVTGSPAINYDFYRGF 188 Methanopyrus kandle... 15598275 157 NVLKSGQIGRLVANNFKSSIVDVPLLEMYPNPKNQSELIKLDYrqfsheleekirdkyqlQNPNVKVHIVGFAKKVGDLI 236 Pseudomonas aerugin... 14521877 142 GLISGDYSSTIIIVNLNREKNQKALVRVYNDIEREIERTNFPQ-----------------GVEVVLTGDLGITYKILEML 204 Pyrococcus abyssi 14590211 183 GLVSRDYSSTIIIVSLNREKNQRALVRVYNEIKNEIEKSNFPE-----------------GVEVVLTGDLGITYKILEML 245 Pyrococcus horikoshii 15643580 129 ----DPNAKSFITEDGKYALLNVIFKEGVNARDKIPEIKRLVSs---------------yFEKNYLFGEPVIDSTLFKEL 189 Thermotoga maritima 15644049 130 FLSYVQSVKDLLNVKKTDDGYYALFMILPEESVPPEKIEKVLS-----------------DYEHYLSGTQYLEDQIFRYL 192 Thermotoga maritima
15639777 234 THDLTLLVPL-VVLIIIVALFVSFRRLAGI-FLPLLTVVISTVWALG-AMALCA-IPLSILSAILPVILIAVGSAYGIHI 309 Treponema pallidum 15594597 201 VEDFKILGPL-ATFVVIISLYLIIKNLIGA-LIPIFIALLSLIWTFG-IKGLVQ-SPITVPETSMIVLLISIGCANAVHI 276 Lyme disease spiroc... 15613283 168 GKETIYAASL-LIPIIVIILIISTTSWIEP-LFFLTAIGVSVLINLG-TNIFIG-EVSFVTQSVSPILQLAVSLDYAIFL 243 Bacillus halodurans 6226453 -------------------------------------------------------------------------------- Methanocaldococcus ... 20094492 189 LKDLVTVTAL-VSAAVAAVLYVDFRRWWAP-VLGLTIILSAVAWVLG-IMYWLGfAPFYATVLLTVVLMLGVGIDYVIFT 265 Methanopyrus kandle... 15598275 237 DGLVMVVGFFgICLLITLVLLYWFTKCIRStIAVLITTLVAVLWQLG-LLNLVG-FGLDPYSMLVPFLIFAIGISHGVQK 314 Pseudomonas aerugin... 14521877 205 QNDMNRTMAI-SGIIVVLILLYFYKSPIRM-LVPLVPLIFGVVMTLG-FMGLLG-IPLDIATTTVGAMIIGMGIDYGVHV 280 Pyrococcus abyssi 14590211 246 QNDMNRTMAV-AGIIVIILLLYFYKSPIRM-LVPLIPLIFGVTMTLG-FMGLLG-IPLDIATSTVGAMIIGMGIDYGVHV 321 Pyrococcus horikoshii 15643580 190 VKQTFVYPVF-MFLVIFLLFYYQLRSFRAA-IFSLIVPVLATFFVFA-VFFAMG-KSLNTMTVMTITFLLIIGSAYGLHF 265 Thermotoga maritima 15644049 193 LFMIFTLPPF-AVVLLLNVFRVQLGRFKYA-IFSLIPAGFAALWTLGiVMGWFG-QDLSIITFLVPIFTIVMGSADGLHF 269 Thermotoga maritima
15639777 310 VSAYFYGASSRicstrQEHRARIVEAVDKIIQPVFLSALTTFVGFVSFCFTSVVPIFEFGVFASVGVASAFAVALMLIPS 389 Treponema pallidum 15594597 277 INEIFKLIKKE-----QLSKESIKATIKKLKTPILLTSFTTAFGFLSLTTSSINAYKTMGIFMSIGVIISMIISLTVLPG 351 Lyme disease spiroc... 15613283 244 LHRFSDYRKQT-----EDPEEAMQIAVRKSFPAIAASAATTFFGFTALTFMQFEIGADLGLNLVKGIVLSFISVMVFLPA 318 Bacillus halodurans 6226453 -------------------------------------------------------------------------------- Methanocaldococcus ... 20094492 266 LTRFQEEYDIKg----RAKGEAILTAVRRAGRAVLITGLTASAGFAALALSEFRMVSEIGLGIVAGILTAVALTLLVLPS 341 Methanopyrus kandle... 15598275 315 INGIALQSSGA-----DNALMAARLTFRQLFLPGMIAILADAVGFITLLVIDIGVIRELAIGASIGVAVIVFTNLILLPV 389 Pseudomonas aerugin... 14521877 281 TNRYYEERGKG-----KSLEEAAEEAIAETGKALLGAALTTIAGFLALSISILPSLKRLSVSLVMGLGLAALNAVIVTPA 355 Pyrococcus abyssi 14590211 322 TNRYYEERNKG-----RSPEEAAEEAISETGKALLGAALTTIAGFLALSLSILPSLKRLSISLVMGLGLAAVNAVIVTPA 396 Pyrococcus horikoshii 15643580 266 YNALFRFSDKR-------------EAVKHIFKPILFSMLTTAAGFMSFVFIDIRAFRELGILVSSGLAVVVLVIFTSGVE 332 Thermotoga maritima 15644049 270 VSHFLERKREG-----ETTFNAVKNTLESVGRAMILTTLTTMAGFLSFLTLNSESMKQMGVLASIGIGLAGVSTWIVLPV 344 Thermotoga maritima
15639777 390 lLIIRGPESR-----VCAHAP------DAGHEHMDTAITGTLMVIAHHYRTVLFVAFLAVVFSLVGMSRLVIDNVLTE-Y 457 Treponema pallidum 15594597 352 -IITLIPFAKkksfeKEKENKln---kISFLERLAKLNTQITKSILKRKYTSSIMVLIILGISFVGLLKIEINFDEKD-Y 426 Lyme disease spiroc... 15613283 319 lTICFYKWID----------K-------TQHRPFFPRFQSIGNGVMKIRFISLAVVSLLIVPSYLAQGQTSFIYGIG--E 379 Bacillus halodurans 6226453 1 ----------------------------MVVLMLREILKKVAHFSEQKPFLMLLIILIITVFAGISATNVKSQTAFEK-M 51 Methanocaldococcus ... 20094492 342 -LLQSIPIGR-------------------KSSEKKEESWKVLSIPVRHPVPAIVALLAITGLLGYGAAGVKPEVNIEK-F 400 Methanopyrus kandle... 15598275 390 -AISYIGISKk----AVQRSKd-----dAVREHPFWRLLSNFSSPKVAPVSIAIALLMLGGGLWYGKHLKIGDLDQGApE 459 Pseudomonas aerugin... 14521877 356 -LAILEEEFRe----KVMKKKeii-aigGGKSKISFIFSMLGKAIKRSPWTALLIALIISGVSLYGASKITTEVRLEK-M 428 Pyrococcus abyssi 14590211 397 -LAILEEEFRt----KILGKKgeiisigGEEGKLGFIFSRLGLFIKRSPWLALLIAVMISGVSLYGATKITTEVRLEK-M 470 Pyrococcus horikoshii 15643580 333 iFRNYTPKR--------------------T-----PRSFGMKYVGRKIALIVLVVFLVMAALSPFLLKRVQVGSDMVS-Y 386 Thermotoga maritima 15644049 345 -ILSRVEKVE-------------------PKNKESGVFRVFQKLSKR----ALVVTIVSVLIFLPGLFFLKADLNILK-L 399 Thermotoga maritima
15639777 458 FEPEVTVVQSDRFMQQHFGGSrsLTVLVSTPARDGs-------vARPDVLKAMDDLTEFLQTRVEHvgkVISLVPLIKRI 530 Treponema pallidum 15594597 427 FKESTSVKKTLNLMQKEMGGI--SIFKIEIEGRPGe-------fKNAKAMQILDLITDKLDAFSAKt-qSSSINGILKFT 496 Lyme disease spiroc... 15613283 380 LPESSRAGSDTATIEEVFGKS--TPIVLLVPKGD---------------VAREVEMEQELEKVDY-------IT-NVISY 434 Bacillus halodurans 6226453 52 LPQDNPIIKTLYEVRDEFGGT--DVITICIKLKPSdssdkvvdiRDPRVLKAIKELEDNLRYVDG----ITSVSSPVDII 125 Methanocaldococcus ... 20094492 401 LGHNLPSLKARDVLEKHMDVSh-HFATIVVEARDV---------RDPKVVRFMEKLKRDAKRTGVAa-rVFGAPDVIGME 469 Methanopyrus kandle... 15598275 460 LRPDSRYNLDNDFIIRNYSTSs-DVLVVMVKTSPEg-------cSTHQALAAMDELAWKLENTEG----VQSAISMVTVS 527 Pseudomonas aerugin... 14521877 429 IPTDLPEIQALSDIRSEFGGQ--DEVTILIKADDV---------RDPTLVRDILRFEREIKADSYIn-nVFETQSIADVV 496 Pyrococcus abyssi 14590211 471 IPMDMPEIQALTDIRSEFGGQ--DEITILIKADDV---------RDPEIVRSILRFEREVKADSYIn-nVFESESIADVV 538 Pyrococcus horikoshii 15643580 387 FERDSELRKAYDLIVKKFNTR--EPIYLVLEKNV------------PFVGTDSKILKELIEKIEK-------SE-YVSSV 444 Thermotoga maritima 15644049 400 YKSYTRVRKNVEKIEEVFGRA--LPVYILFESENL---------FDPSFAQKVLSMEEDLKKEGF------DAFSMYDII 462 Thermotoga maritima
15639777 531 NQVYNADAsargleaqsadvvrggtddfgvfktftggheePARAEtsrtsLAApgssydfrqavgmlvsavrdsdfdrsd 610 Treponema pallidum 15594597 497 NFKIKKES--------------------------------PLEYKlp--eNKI--------------------------- 515 Lyme disease spiroc... 15613283 435 NQSVSATI--------------------------------P--------------------------------------- 443 Bacillus halodurans 6226453 126 IQKNNGIV--------------------------------PNDIDt----VKD--------------------------- 142 Methanocaldococcus ... 20094492 470 KTVERLPA--------------------------------P---------IRS--------------------------- 481 Methanopyrus kandle... 15598275 528 KQVIKGMN--------------------------------EGNLKwetlsRNQd-------------------------- 549 Pseudomonas aerugin... 14521877 497 IQKYGYIP--------------------------------QDKEK-------I--------------------------- 510 Pyrococcus abyssi 14590211 539 IEKYGYIP--------------------------------EDKEK-------I--------------------------- 552 Pyrococcus horikoshii 15643580 445 VFPVDIPV--------------------------------P-----------I--------------------------- 454 Thermotoga maritima 15644049 463 SKLNERLF--------------------------------KEKG--------Y--------------------------- 475 Thermotoga maritima
15639777 611 aqqlvqalekavnydgrAYYEIPCDPKKYGVKTSEelqEIISGYLLLLSGKGLGLVDRAVDPRALKMNIQLGtkgqqdsy 690 Treponema pallidum 15594597 516 -----------------ILNKLINLIDKSDWTKDNkrmYINDDWSLISIIVRIEDNSTEGIKKFEKYAINTIney----- 573 Lyme disease spiroc... 15613283 444 ------------------SEYIDESVTEQFYSEHY---SQIILYTETDVEGEVAFSVVETVQEIAASYYGDD-------- 494 Bacillus halodurans 6226453 143 -----------------ILNKLPEDKRKRIFNSDYsmtVVNAYTDAGGDQKKLMRVMDDVNERIEETPFPPG-------- 197 Methanocaldococcus ... 20094492 482 -----------------ALEPKVEDMEKGVISGDG----KVAVIQVQLKPGDPKVQGRKILDMVRHEHPPTG-------- 532 Methanopyrus kandle... 15598275 550 -----------------VLNNSIARADGLYNTDCS---LAPLLVFLNDHKAETLDRAVAAVQAFAAENDKDDl------- 602 Pseudomonas aerugin... 14521877 511 -----------------SEAIEGSSLVSSDYSMTI---IKLKGNFMGVTQSEFNRIMEYFERAIQRADFPPG-------- 562 Pyrococcus abyssi 14590211 553 -----------------AKALEGSSLVSSDYSLTI---VKLKGNFMGVTQEDFNKIMEYFEEELKRANFPPG-------- 604 Pyrococcus horikoshii 15643580 455 -----------------MYTLSRTNPFLKTFVGDR----NRIRLIVNLTPEGYEHVK-KVVDLINEVVSETG-------- 504 Thermotoga maritima 15644049 476 -----------------PKILARALILKRLLPDEYt--ENLVSGNTGRAFVFLNDLDREILVKVENVVEKHG-------- 528 Thermotoga maritima
15639777 691 gvieavkkfirenfpqdVHAEFGGSVLVEQSLNDLVVQSQLISLVFSLCVVFIIIAVHYRSLFAGIIGTLPLGVSVLVNF 770 Treponema pallidum 15594597 574 ---------------mkNNKYHFSGVYDKVLIAKTMVKEQVINIITTLGSITLLLMFFFKSIKTGIIIAIPVAWSVFLNF 638 Lyme disease spiroc... 15613283 495 -------------------ALSLGESVSLYDMKTTIMKDNRVVNLLTVVAIAIVLLLTFRSISIPVILLLTIQSAVWLNL 555 Bacillus halodurans 6226453 198 -----------------VEVIATGTPPMRKLMDELMKESQSFTTTVGLIGILIILIIYFRKPLSSIMPLLPVLIAVIWTG 260 Methanocaldococcus ... 20094492 533 -----------------VKVGVTGLPVAFAEMHEQVNEDMRRSTIASAIGVLAIPTIAFRNPIPPVFGLVAIGSGILWAI 595 Methanopyrus kandle... 15598275 603 -----------------QFQLAAGNAGIEAATNEVIKQSELIILVLVYICVAAMCMITFRSFAATLCIVLPLILTSVLGN 665 Pseudomonas aerugin... 14521877 563 -----------------VKVELAGESYLNYVLNDLVNEELGKISTIGTLIVVMVVFAIFRRPTVSIAMIMPMFLGALWTI 625 Pyrococcus abyssi 14590211 605 -----------------VKAELAGESYLNYVLDNLVNEELGKISTIGTIIVVLIVFAIFRRPTVAVAMIMPMFLGALWTI 667 Pyrococcus horikoshii 15643580 505 -----------------WSHYVAGSVLIWNDINESIMRSQIQSIVLASILIFAMVFIIFRRPLTTLSVMIPIAFTTVFNF 567 Thermotoga maritima 15644049 529 -------------------FQVTGIPYIIKEMNDSIVPQQLLSVFLAISMVFLLLVLFQRSFLYPAKAIVPVGISLVSLF 589 Thermotoga maritima
15639777 771 GVMGFFG--IKLNICTTMVAGFSSGIGVDYTIHYLAAYRRAWKEC--GGKDFlTQTFYGSGRAILFNVLSVGSGFAVLML 846 Treponema pallidum 15594597 639 AVMRLFG--ITLNPATATIASVSMGVGVDYSIHFFNTFILQYQKNqiYKTAL-LESIPNVFNGIFANSISVGIGFLTLTF 715 Lyme disease spiroc... 15613283 556 AVPYFTDa-PLVYLGYLIVGTVQLAATVDYAILYTEGYLVNRRKm-pRRQAItKTLTEKTFSISISAAILSSVGFILWLT 633 Bacillus halodurans 6226453 261 GAMGLLD--IPLDMATAGIGSLILGLGIDYGIHLMHRYDEERRKGmpIDKAI-ETAVVETGTAVMATTATTVVGFLALVL 337 Methanocaldococcus ... 20094492 596 GLLGGVLriVPSFLAMQTTICILLGIGMDYCVFLASRYREERKEh-gVKEAW-THTMERAGPGVLFSGLTSAIGFLSLLL 673 Methanopyrus kandle... 15598275 666 ALMAALG--IGVKVATLPVIALGVGIGVDYGIYIYTRLESFLRMGlpLQEAY-YETLRSTGKAVLFTGLCLAIGVATWIF 742 Pseudomonas aerugin... 14521877 626 GYMGLAG--IPFSQTLAGVVSMIVGLGVDYGMHITHRFLEELNEg--NKTPI-ITALESVGPGIFVGALTTAGGFLALLS 700 Pyrococcus abyssi 14590211 668 GYMGLAG--IPFSQTLAGVVSMIVGLGVDYGMHITHRFLEELKEg--NKTPI-ITAMESVGPGILIGALTTAGGFLALLT 742 Pyrococcus horikoshii 15643580 568 LFMALFG--ISLDVSTSITSGILMGLVIDYSIHIASEERRLRDP---------YLVVKNVGPSVLTNALGLISGFAVLLF 636 Thermotoga maritima 15644049 590 GFMGLSG--IPLNLITANMAGIVIGVGIDYAIHVTELFR--YYGD------I-EKTVRIASTPVLANAFGLSIGLSALIL 658 Thermotoga maritima
15639777 847 SKFNVLADFGLLMVLAMLTSSVASLTLLPTLLNVVKPRFIT 887 Treponema pallidum 15594597 716 SSYKIISTLGAIIAFTMLTTSLASLTLLPLLIYLFKPRVKL 756 Lyme disease spirochete 15613283 634 SSNPVVSSIGLLLGRGALLAFILVIFFLPAMLLVFDKAIRK 674 Bacillus halodurans 6226453 338 APLPMMANLGKVCALGISFCMVVVLTLLPALIVIEERHIMP 378 Methanocaldococcus jannaschii 20094492 674 SHTGIMRNMGLYQGIGVLSTLTLVLVGFPALYVVISRVFSR 714 Methanopyrus kandleri AV19 15598275 743 SAIKFQADMGLMLTFMLLWNMFGALWLLPALARFLINPAKL 783 Pseudomonas aeruginosa PA01 14521877 701 AQLTAIHDFGRVLAVGIFASMFAAYLVTPAILQLEFGRKIS 741 Pyrococcus abyssi 14590211 743 GRLTAIHDFGKVLAVGIFSSMLAAYLVTPAILQLEFGRKIk 783 Pyrococcus horikoshii 15643580 637 SELALFKNISLLMMLGIGVGAIFTLIVQPMILEKRENS--- 674 Thermotoga maritima 15644049 659 SPFTFHTYLVAIMWVTMTVSSFMSLVILPKLLEAKK----- 694 Thermotoga maritima
Jiyao W et al.(2023). "The conserved domain database in 2023.",